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Index > Protein center > Shprh(Gene name) > Mouse
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  • Shprh (Gene name),
  • E3 ubiquitin-protein ligase SHPRH (Protein name ),  SHPRH_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Shprh;
    Protein name:
    E3 ubiquitin-protein ligase SHPRH;
    Alternative:
    SNF2, histone-linker, PHD and RING finger domain-containing helicase;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homodimer. Interacts with HLTF, PCNA, UBE2N and RAD18.
    Function:
    E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    1674
    Sequence:
    50:
    MSSRRKRAPP | MKVDEERQQQ | LHWNMHEDLR | SEPLTMTVGE | QACSDADSSS | 
    100:
    DCIIIDEGPP | ESALHRDKKR | RSETVSVLEA | TEEETRLSVT | LNVTVSPYRV | 
    150:
    DNSWKAFLGD | FALQLLPKES | LVEHFSERTF | TLSPSESSSQ | FLIYVHSECK | 
    200:
    NVEKQENVLE | GSAGVCSKGI | RVESSFSSDM | LQDLAWLQKR | RGIKLYQRPD | 
    250:
    GTHTIKVGIY | ILEAGLTRLD | FMSDAGSRMK | KFNQLMKRVM | EKLHNFIIPD | 
    300:
    VLEEEEEGSE | SEPEGQDIDE | LYHFVKQTHQ | QETRSVQVDV | QHPALIPVLR | 
    350:
    PYQREAVNWM | LQQEQFRSAP | PADNSLHFLW | REIVTPDGLK | LYYNPYTGCI | 
    400:
    IRDFPHAGPQ | LLGGILADEM | GLGKTVEVLA | LILTHTRQDV | KQDALTLPEG | 
    450:
    KVVNYFIPTH | CPREKVKNRE | IQDTEYEPKE | KVHCPPTRVM | ILTAVKEMNG | 
    500:
    KKGVSILSIY | KYVSSIFRYD | VQRNRGLLKR | MLKCLIFEGL | VKQIKGHGFS | 
    550:
    GTFTLGKNYK | EDVFDKTKKQ | AVGSPRKIEK | ELRKSVNKDA | DSEYLPSNTS | 
    600:
    DDDEPYYYYC | KAGKSRSKLK | KPALLTKKGK | GQSVHLDSQG | DAPAAGVCAS | 
    650:
    TDVHVSENTC | VSEDKQTQEA | KDCAESPNPA | AEELAQSNTS | SPCETSDYRF | 
    700:
    ECICGEFDQI | GHKPRVQCLK | CHLWQHAKCV | NYEEKNLKVK | PFYCPHCLVA | 
    750:
    MEPVSTRATL | IISPSSICHQ | WVDEINRHVR | SSSLRVLVYQ | GVKKHGFLQP | 
    800:
    HFLAEQDIVI | ITYDVLRSEL | NYVNIPHSNS | EDGRRLRNQK | RYMAIPSPLV | 
    850:
    AVEWWRICLD | EAQMVECPTV | KAAEMAQRLS | GINRWCISGT | PVQRGLEDLF | 
    900:
    GLVVFLGIEP | YCVKHWWIRL | LYHPYCKKNP | QHLYSFIAKI | MWRSAKKDVI | 
    950:
    DQIQIPPQTE | EMHWLHFSPV | ERHFYHRQHE | VCCQDAIVKL | RKISDWALKL | 
    1000:
    SSLDRRTVSS | ILYPLLRLRQ | ACCHPQAVRG | EFLPLQKSTM | TMEELLTSLQ | 
    1050:
    KKCGTECEEA | HRQLVCALNG | LAGIHIIKGE | YALAAELYRE | VLRSSEEHKG | 
    1100:
    KLKTDSLQRL | HATHNLMELL | GAKHPGIPPT | LRDGRLEEEA | KQLREHYMSK | 
    1150:
    CNTEVAEAQQ | ALQPVQQSIR | ELQRKIHSNS | PWWLNVIHRA | MEFSVDEELV | 
    1200:
    QRVRNEISSN | YKQQTDKLSM | SEKFRDCRGL | QFLLTTQMEE | LHKFQKLVRE | 
    1250:
    AVKKLEKPPS | REVIESATVC | HLRPARLPLN | CCVFCKADEL | FTEYESKLFF | 
    1300:
    NTVKGQTAIF | EEMIEDEEGL | VDDRVPTTTR | GLWAVSETER | SMKAILSFAR | 
    1350:
    SHRFDVEYVD | EGSVSMDLFE | AWKKEYKLLH | EYWMTLRNRV | SAVDELAMAT | 
    1400:
    ERLRVRHPKE | PKPNPPVHHI | IEPHEVEQNR | IKLVNDKAVA | TSQLQKKLGQ | 
    1450:
    LLYLTNLEKS | QDKTSGGINP | EPCPICARQL | GKQWAVLTCG | HCFCNECTSI | 
    1500:
    IIEQYSVGSH | RSSIKCAICR | QTTSHKEVSY | VFTSEKANQE | DDIPVKGSHS | 
    1550:
    TKVEAVVRTL | MKIQLRDPGA | KALVFSTWQD | VLDIISKALT | DNNMEFTQIS | 
    1600:
    RIKTFQENLS | AFKYDPHINI | LLLPLHTGSN | GLTIIEATHV | LLVEPILNPA | 
    1650:
    HELQAIGRVH | RIGQTKPTIV | HRFLIKATIE | ERMQAMLKTA | ERSHTSSSGK | 
    1674:
    HSEASVLTVA | GLADLFTKEN | EELE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    SMR:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse E3 ubiquitin-protein ligase SHPRH
    ELISA Kit for Mouse E3 ubiquitin-protein ligase SHPRH
    CLIA Kit for Mouse E3 ubiquitin-protein ligase SHPRH
    CLIA Kit for Mouse E3 ubiquitin-protein ligase SHPRH
    Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase SHPRH
    Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase SHPRH
    Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase SHPRH
    Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase SHPRH
    Protein for Mouse E3 ubiquitin-protein ligase SHPRH
    Protein for Mouse E3 ubiquitin-protein ligase SHPRH

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Cloning and characterization of a novel gene, SHPRH, encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from the 6q24 region."
      Sood R. , Makalowska I. , Galdzicki M. , Hu P. , Eddings E. , Robbins C.M. , Moses T. , Namkoong J. , Chen S. , Trent J.M.
      Genomics82:153-161(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 4);TISSUE SPECIFICITY
      strain: BALB/c.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      strain: C57BL/6J.
      tissue: Cerebellum.
      tissue: Eye.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: C57BL/6.
      strain: FVB/N.
      tissue: Mammary tumor.
      tissue: Retina.
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