Protein name:
E3 ubiquitin-protein ligase SHPRH ;
Alternative:
SNF2, histone-linker, PHD and RING finger domain-containing helicase ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Homodimer. Interacts with HLTF, PCNA, UBE2N and RAD18.
Function:
E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'.
Subcellular Location:
N/A
Protein Attributes:
50:
MSSRRKRAPP | MKVDEERQQQ | LHWNMHEDLR | SEPLTMTVGE | QACSDADSSS |
100:
DCIIIDEGPP | ESALHRDKKR | RSETVSVLEA | TEEETRLSVT | LNVTVSPYRV |
150:
DNSWKAFLGD | FALQLLPKES | LVEHFSERTF | TLSPSESSSQ | FLIYVHSECK |
200:
NVEKQENVLE | GSAGVCSKGI | RVESSFSSDM | LQDLAWLQKR | RGIKLYQRPD |
250:
GTHTIKVGIY | ILEAGLTRLD | FMSDAGSRMK | KFNQLMKRVM | EKLHNFIIPD |
300:
VLEEEEEGSE | SEPEGQDIDE | LYHFVKQTHQ | QETRSVQVDV | QHPALIPVLR |
350:
PYQREAVNWM | LQQEQFRSAP | PADNSLHFLW | REIVTPDGLK | LYYNPYTGCI |
400:
IRDFPHAGPQ | LLGGILADEM | GLGKTVEVLA | LILTHTRQDV | KQDALTLPEG |
450:
KVVNYFIPTH | CPREKVKNRE | IQDTEYEPKE | KVHCPPTRVM | ILTAVKEMNG |
500:
KKGVSILSIY | KYVSSIFRYD | VQRNRGLLKR | MLKCLIFEGL | VKQIKGHGFS |
550:
GTFTLGKNYK | EDVFDKTKKQ | AVGSPRKIEK | ELRKSVNKDA | DSEYLPSNTS |
600:
DDDEPYYYYC | KAGKSRSKLK | KPALLTKKGK | GQSVHLDSQG | DAPAAGVCAS |
650:
TDVHVSENTC | VSEDKQTQEA | KDCAESPNPA | AEELAQSNTS | SPCETSDYRF |
700:
ECICGEFDQI | GHKPRVQCLK | CHLWQHAKCV | NYEEKNLKVK | PFYCPHCLVA |
750:
MEPVSTRATL | IISPSSICHQ | WVDEINRHVR | SSSLRVLVYQ | GVKKHGFLQP |
800:
HFLAEQDIVI | ITYDVLRSEL | NYVNIPHSNS | EDGRRLRNQK | RYMAIPSPLV |
850:
AVEWWRICLD | EAQMVECPTV | KAAEMAQRLS | GINRWCISGT | PVQRGLEDLF |
900:
GLVVFLGIEP | YCVKHWWIRL | LYHPYCKKNP | QHLYSFIAKI | MWRSAKKDVI |
950:
DQIQIPPQTE | EMHWLHFSPV | ERHFYHRQHE | VCCQDAIVKL | RKISDWALKL |
1000:
SSLDRRTVSS | ILYPLLRLRQ | ACCHPQAVRG | EFLPLQKSTM | TMEELLTSLQ |
1050:
KKCGTECEEA | HRQLVCALNG | LAGIHIIKGE | YALAAELYRE | VLRSSEEHKG |
1100:
KLKTDSLQRL | HATHNLMELL | GAKHPGIPPT | LRDGRLEEEA | KQLREHYMSK |
1150:
CNTEVAEAQQ | ALQPVQQSIR | ELQRKIHSNS | PWWLNVIHRA | MEFSVDEELV |
1200:
QRVRNEISSN | YKQQTDKLSM | SEKFRDCRGL | QFLLTTQMEE | LHKFQKLVRE |
1250:
AVKKLEKPPS | REVIESATVC | HLRPARLPLN | CCVFCKADEL | FTEYESKLFF |
1300:
NTVKGQTAIF | EEMIEDEEGL | VDDRVPTTTR | GLWAVSETER | SMKAILSFAR |
1350:
SHRFDVEYVD | EGSVSMDLFE | AWKKEYKLLH | EYWMTLRNRV | SAVDELAMAT |
1400:
ERLRVRHPKE | PKPNPPVHHI | IEPHEVEQNR | IKLVNDKAVA | TSQLQKKLGQ |
1450:
LLYLTNLEKS | QDKTSGGINP | EPCPICARQL | GKQWAVLTCG | HCFCNECTSI |
1500:
IIEQYSVGSH | RSSIKCAICR | QTTSHKEVSY | VFTSEKANQE | DDIPVKGSHS |
1550:
TKVEAVVRTL | MKIQLRDPGA | KALVFSTWQD | VLDIISKALT | DNNMEFTQIS |
1600:
RIKTFQENLS | AFKYDPHINI | LLLPLHTGSN | GLTIIEATHV | LLVEPILNPA |
1650:
HELQAIGRVH | RIGQTKPTIV | HRFLIKATIE | ERMQAMLKTA | ERSHTSSSGK |
1674:
HSEASVLTVA | GLADLFTKEN | EELE
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
ELISA Kit for Mouse E3 ubiquitin-protein ligase SHPRH
ELISA Kit for Mouse E3 ubiquitin-protein ligase SHPRH
CLIA Kit for Mouse E3 ubiquitin-protein ligase SHPRH
CLIA Kit for Mouse E3 ubiquitin-protein ligase SHPRH
Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase SHPRH
Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase SHPRH
Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase SHPRH
Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase SHPRH
Protein for Mouse E3 ubiquitin-protein ligase SHPRH
Protein for Mouse E3 ubiquitin-protein ligase SHPRH
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 4);TISSUE SPECIFICITY
strain :
BALB/c .
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
strain :
C57BL/6J .
tissue :
Cerebellum .
tissue :
Eye .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain :
C57BL/6 .
strain :
FVB/N .
tissue :
Mammary tumor .
tissue :
Retina .