Gene name:
ST3GAL1 (SIAT4A) ;
Protein name:
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (Alpha 2,3-ST 1;Beta-galactoside alpha-2,3-sialyltransferase 1) ;
Alternative:
Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase ;Gal-NAc6S ;ST3GalA.1 ;ST3Gal I (ST3GalI) ;Sialyltransferase 4A (SIAT4-A) ;ST3O ;
Organism:
Pig (Sus scrofa).
General Annotation
Function:
It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found on sugar chains O-linked to Thr or Ser and also as a terminal sequence on certain gangliosides. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values. The short isoform seems to be catalytically inactive.
Subcellular Location:
Golgi apparatus
Golgi stack membrane
Single-pass type II membrane protein
Secreted
Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.
Protein Attributes:
50:
MAPMRKKSTL | KLLTLLVLFI | FLTSFFLNYS | HTVVTTAWFP | KQMVIELSEN |
100:
FKKLMKYPYR | PCTCTRCIEE | QRVSAWFDER | FNRSMQPLLT | AKNAHLEEDT |
150:
YKWWLRLQRE | KQPNNLNDTI | RELFQVVPGN | VDPLLEKRLV | SCRRCAVVGN |
200:
SGNLKESYYG | PQIDSHDFVL | RMNKAPTEGF | EADVGSKTTH | HFVYPESFRE |
250:
LAQEVSMILV | PFKTTDLEWV | ISATTTGRIS | HTYVPVPAKI | KVKKEKILIY |
300:
HPAFIKYVFD | RWLQGHGRYP | STGILSVIFS | LHICDEVDLY | GFGADSKGNW |
343:
HHYWENNPSA | GAFRKTGVHD | GDFESNVTTI | LASINKIRIF | KGR
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Chicken
Mouse
Pig
Human
ELISA Kit for Pig Alpha 2,3-ST 1
ELISA Kit for Pig Alpha 2,3-ST 1
ELISA Kit for Pig Alpha 2,3-ST 1
ELISA Kit for Pig Alpha 2,3-ST 1
CLIA Kit for Pig Alpha 2,3-ST 1
CLIA Kit for Pig Alpha 2,3-ST 1
CLIA Kit for Pig Alpha 2,3-ST 1
CLIA Kit for Pig Alpha 2,3-ST 1
Polyclonal Antibody for Pig Alpha 2,3-ST 1
Polyclonal Antibody for Pig Alpha 2,3-ST 1
Polyclonal Antibody for Pig Alpha 2,3-ST 1
Polyclonal Antibody for Pig Alpha 2,3-ST 1
Monoclonal Antibody for Pig Alpha 2,3-ST 1
Monoclonal Antibody for Pig Alpha 2,3-ST 1
Monoclonal Antibody for Pig Alpha 2,3-ST 1
Monoclonal Antibody for Pig Alpha 2,3-ST 1
Protein for Pig Alpha 2,3-ST 1
Protein for Pig Alpha 2,3-ST 1
Protein for Pig Alpha 2,3-ST 1
Protein for Pig Alpha 2,3-ST 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 8-29 AND 56-77;ALTERNATIVE SPLICING
tissue :
Liver .
tissue :
Salivary gland .
2.
"Structural insight into mammalian sialyltransferases."
Rao F.V.
,
Rich J.R.
,
Rakic B.
,
Buddai S.
,
Schwartz M.F.
,
Johnson K.
,
Bowe C.
,
Wakarchuk W.W.
,
Defrees S.
,
Withers S.G.
,
Strynadka N.C.
Nat. Struct. Mol. Biol.16:1186-1188(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.25 ANGSTROMS) OF 46-343 IN COMPLEXES WITH CMP AND N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE;CATALYTIC ACTIVITY;FUNCTION;DISULFIDE BONDS