Slc9a4 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comSlc9a4 ELISA Kit for Rat(Rattus norvegicus)

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Slc9a4 (Gene name),

Sodium/hydrogen exchanger 4 (Protein name ), SL9A4_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Slc9a4(Nhe4);

Protein name:

Sodium/hydrogen exchanger 4;

Alternative:

Solute carrier family 9 member 4;Na(+)/H(+) exchanger 4(NHE-4);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

N/A

Function:

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. May play a specialized role in the kidney in rectifying cell volume in response to extreme fluctuations of hyperosmolar-stimulated cell shrinkage. Is relatively amiloride and ethylisopropylamiloride (EIPA) insensitive. Can be activated under conditions of hyperosmolar-induced cell shrinkage in a sustained intracellular acidification-dependence manner. Activated by 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) in a sustained intracellular acidification-dependence manner. Affects potassium/proton exchange as well as sodium/proton and lithium/proton exchange. In basolateral cell membrane, participates in homeostatic control of intracellular pH, and may play a role in proton extrusion in order to achieve transepithelial HCO3(-) secretion. In apical cell membrane may be involved in mediating sodium absorption. Requires for normal levels of gastric acid secretion, secretory membrane development, parietal cell maturation and/or differentiation and at least secondarily for chief cell differentiation.

Subcellular Location:

Apical cell membrane Multi-pass membrane protein Basolateral cell membrane Multi-pass membrane protein Cytoplasmic granule membrane Multi-pass membrane protein Found in zymogen granule membranes.

Protein Attributes:

Sequence length:

717

Sequence:

50:

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300:

350:

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450:

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600:

650:

700:

717:

GPGGQETQPR | LLCRNLN

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00999

UniGene:

Rn.9707

SMR:

P26434

STRING:

10116.ENSRNOP00000020716

String:

P26434

KEGG:

rno:24785

Uniprot:

P26434

FOR

ELISA Kit for Rat Sodium/hydrogen exchanger 4

CLIA Kit for Rat Sodium/hydrogen exchanger 4

Polyclonal Antibody for Rat Sodium/hydrogen exchanger 4

Monoclonal Antibody for Rat Sodium/hydrogen exchanger 4

Protein for Rat Sodium/hydrogen exchanger 4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins."
Orlowski J. , Kandasamy R.A. , Shull G.E.
J. Biol. Chem.267:9331-9339(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
strain: Sprague-Dawley.
tissue: Stomach.
2.

"A unique sodium-hydrogen exchange isoform (NHE-4) of the inner medulla of the rat kidney is induced by hyperosmolarity."
Bookstein C. , Musch M.W. , DePaoli A. , Xie Y. , Villereal M. , Rao M.C. , Chang E.B.
J. Biol. Chem.269:29704-29709(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;INDUCTION
3.

"Characterization of the rat Na+/H+ exchanger isoform NHE4 and localization in rat hippocampus."
Bookstein C. , Musch M.W. , DePaoli A. , Xie Y. , Rabenau K. , Villereal M. , Rao M.C. , Chang E.B.
Am. J. Physiol.271:C1629-C1638(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
4.

"Heterologous expression of rat NHE4: a highly amiloride-resistant Na+/H+ exchanger isoform."
Chambrey R. , Achard J.-M. , Warnock D.G.
Am. J. Physiol.272:C90-C98(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
5.

"Tissue distribution of Na+/H+ exchanger isoforms NHE2 and NHE4 in rat intestine and kidney."
Bookstein C. , Xie Y. , Rabenau K. , Musch M.W. , McSwine R.L. , Rao M.C. , Chang E.B.
Am. J. Physiol.273:C1496-C1505(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
6.

"Immunochemical characterization of Na+/H+ exchanger isoform NHE4."
Pizzonia J.H. , Biemesderfer D. , Abu-Alfa A.K. , Wu M.-S. , Exner M. , Isenring P. , Igarashi P. , Aronson P.S.
Am. J. Physiol.275:F510-F517(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
7.

"Expression of NHE1 and NHE4 in rat pancreatic zymogen granule membranes."
Anderie I. , Blum R. , Haase W. , Grinstein S. , Thevenod F.
Biochem. Biophys. Res. Commun.246:330-336(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
8.

"Expression of Na+/H+ exchanger isoforms in inner segment of inner medullary collecting duct."
Sun A.M. , Liu Y. , Centracchio J. , Dworkin L.D.
J. Membr. Biol.164:293-300(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
9.

"Localization and functional characterization of Na+/H+ exchanger isoform NHE4 in rat thick ascending limbs."
Chambrey R. , St John P.L. , Eladari D. , Quentin F. , Warnock D.G. , Abrahamson D.R. , Podevin R.-A. , Paillard M.
Am. J. Physiol.281:F707-F717(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
10.

"Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium."
Inoue H. , Nakamura Y. , Nagita M. , Takai T. , Masuda M. , Nakamura N. , Kanazawa H.
Biol. Pharm. Bull.26:148-155(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CHP1 AND CHP2
11.

"Na(+)/H(+) exchanger isoforms are differentially regulated in rat submandibular gland during acid/base disturbances in vivo."
Oehlke O. , Sprysch P. , Rickmann M. , Roussa E.
Cell Tissue Res.323:253-262(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY

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