SMAD1 ELISA Kit for Human(Homo sapiens) | EIAab.comSMAD1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > SMAD1(Gene name) > Human

SMAD1 (Gene name),

Mothers against decapentaplegic homolog 1 (Protein name ), SMAD1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

SMAD1(BSP1;MADH1;MADR1);

Protein name:

Mothers against decapentaplegic homolog 1(MAD homolog 1;Mothers against DPP homolog 1);

Alternative:

Mad-related protein 1;JV4-1;Transforming growth factor-beta-signaling protein 1(BSP-1);SMAD family member 1(SMAD 1;Smad1;hSMAD1);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with HGS, NANOG and ZCCHC12 (By similarity). May form trimers with another SMAD1 and the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit, CREB-binding protein (CBP), p300, SMURF1, SMURF2 and HOXC8. Associates with ZNF423 or ZNF521 in response to BMP2 leading to activate transcription of BMP target genes. Interacts with SKOR1. Interacts (via MH2 domain) with LEMD3. Binding to LEMD3 results in at least a partial reduction of receptor-mediated phosphorylation. Forms a ternary complex with PSMB4 and OAZ1 before PSMB4 is incorporated into the 20S proteasome.

Function:

Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.

Subcellular Location:

Cytoplasm Nucleus Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. Co-localizes with LEMD3 at the nucleus inner membrane.

Protein Attributes:

Sequence length:

465

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

465:

LTQMGSPHNP | ISSVS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q15797

KEGG:

hsa:4086

UniGene:

Hs.604588

STRING:

9606.ENSP00000305769

String:

Q15797

MIM:

601595

Pfam:

PF03165

Uniprot:

Q15797

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ELISA Kit for Human MAD homolog 1

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E0647h

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ELISA Kit for Human MAD homolog 1

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E0647b

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96T

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ELISA Kit for Human MAD homolog 1

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E0647m

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96T

ELISA Kit for Human MAD homolog 1

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E0647r

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96T

CLIA Kit for Human MAD homolog 1

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U0647m

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96T

CLIA Kit for Human MAD homolog 1

Cat.:

U0647r

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96T

CLIA Kit for Human MAD homolog 1

Cat.:

U0647h

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96T

CLIA Kit for Human MAD homolog 1

Cat.:

U0647b

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96T

Polyclonal Antibody for Human MAD homolog 1

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P0647Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human MAD homolog 1

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P0647Rb-r

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Polyclonal Antibody for Human MAD homolog 1

Cat.:

P0647Rb-h

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40ug/0.2ml

Monoclonal Antibody for Human MAD homolog 1

Protein for Human MAD homolog 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Mad-related genes in the human."
Riggins G.J. , Thiagalingam S. , Rosenblum E. , Weinstein C.L. , Kern S.E. , Hamilton S.R. , Willson J.K.V. , Markowitz S.D. , Kinzler K.W. , Vogelstein B.V.
Nat. Genet.13:347-349(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"A human Mad protein acting as a BMP-regulated transcriptional activator."
Liu F. , Hata A. , Baker J.C. , Doody J. , Carcamo J. , Harland R.M. , Massague J.
Nature381:620-623(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Kidney.
3.

"MADR1, a MAD-related protein that functions in BMP2 signaling pathways."
Hoodless P.A. , Haerry T. , Abdollah S. , Stapleton M. , O'Connor M.B. , Attisano L. , Wrana J.L.
Cell85:489-500(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);MUTAGENESIS OF GLY-419
4.

"Serine phosphorylation, chromosomal localization, and transforming growth factor-beta signal transduction by human bsp-1."
Lechleider R.J. , de Caestecker M.P. , Dehejia A. , Polymeropoulos M.H. , Roberts A.B.
J. Biol. Chem.271:17617-17620(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Mammary carcinoma.
5.

"Receptor-associated Mad homologues synergize as effectors of the TGF-beta response."
Zhang Y. , Feng X.-H. , Wu R.-Y. , Derynck R.
Nature383:168-172(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Placenta.
6.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
7.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Uterus.
8.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Uterus.
9.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Placenta.
11.

Bienvenut W.V. , Lempens A. , Norman J.C.
Submitted (2009-10) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1-15; 33-39; 129-157; 283-306 AND 309-319;ACETYLATION AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Ovarian carcinoma.
12.

"The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase."
Kretzschmar M. , Liu F. , Hata A. , Doody J. , Massague J.
Genes Dev.11:984-995(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-463 AND SER-465
13.

"TGF-beta signal transduction."
Massague J.
Annu. Rev. Biochem.67:753-791(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
14.

"Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells."
Verschueren K. , Huylebroeck D.
Cytokine Growth Factor Rev.10:187-199(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
15.

"OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways."
Hata A. , Seoane J. , Lagna G. , Montalvo E. , Hemmati-Brivanlou A. , Massague J.
Cell100:229-240(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ZNF423
16.

"The Smad pathway."
Wrana J.L. , Attisano L.
Cytokine Growth Factor Rev.11:5-13(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
17.

"TGF-beta signaling by Smad proteins."
Miyazono K.
Cytokine Growth Factor Rev.11:15-22(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
18.

"A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic proteins (BMPs)."
Lin Y. , Martin J. , Gruendler C. , Farley J. , Meng X. , Li B.-Y. , Lechleider R. , Huff C. , Kim R.H. , Grasser W.A. , Paralkar V. , Wang T.
BMC Cell Biol.3:15-15(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH PSMB4 AND OAZ1;FUNCTION
19.

"Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells."
Bond H.M. , Mesuraca M. , Carbone E. , Bonelli P. , Agosti V. , Amodio N. , De Rosa G. , Di Nicola M. , Gianni A.M. , Moore M.A. , Hata A. , Grieco M. , Morrone G. , Venuta S.
Blood103:2062-2070(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ZNF521
20.

"The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-{beta} superfamily of cytokines."
Pan D. , Estevez-Salmeron L.D. , Stroschein S.L. , Zhu X. , He J. , Zhou S. , Luo K.
J. Biol. Chem.280:15992-16001(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH LEMD3
21.

"Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling."
Arndt S. , Poser I. , Moser M. , Bosserhoff A.-K.
Mol. Cell. Neurosci.34:603-611(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SKOR1
22.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
23.

"Smad inhibition by the Ste20 kinase Misshapen."
Kaneko S. , Chen X. , Lu P. , Yao X. , Wright T.G. , Rajurkar M. , Kariya K. , Mao J. , Ip Y.T. , Xu L.
Proc. Natl. Acad. Sci. U.S.A.108:11127-11132(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-322
24.

"USP15 is a deubiquitylating enzyme for receptor-activated SMADs."
Inui M. , Manfrin A. , Mamidi A. , Martello G. , Morsut L. , Soligo S. , Enzo E. , Moro S. , Polo S. , Dupont S. , Cordenonsi M. , Piccolo S.
Nat. Cell Biol.13:1368-1375(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;DEUBIQUITINATION BY USP15;DNA-BINDING;INTERACTION WITH USP15
25.

"Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-? pathway."
Bruce D.L. , Macartney T. , Yong W. , Shou W. , Sapkota G.P.
Cell. Signal.24:1999-2006(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
26.

"Molecular genetic characterization of SMAD signaling molecules in pulmonary arterial hypertension."
Nasim M.T. , Ogo T. , Ahmed M. , Randall R. , Chowdhury H.M. , Snape K.M. , Bradshaw T.Y. , Southgate L. , Lee G.J. , Jackson I. , Lord G.M. , Gibbs J.S. , Wilkins M.R. , Ohta-Ogo K. , Nakamura K. , Girerd B. , Coulet F. , Soubrier F. , more...
Hum. Mutat.32:1385-1389(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE INVOLVEMENT IN PULMONARY HYPERTENSION;VARIANT ALA-3;CHARACTERIZATION OF VARIANT ALA-3
27.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
28.

"Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling."
Vogt J. , Dingwell K.S. , Herhaus L. , Gourlay R. , Macartney T. , Campbell D. , Smith J.C. , Sapkota G.P.
Open Biol.4:130210-130210(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FAM83G
29.

"Structural basis of Smad1 activation by receptor kinase phosphorylation."
Qin B.Y. , Chacko B.M. , Lam S.S. , de Caestecker M.P. , Correia J.J. , Lin K.
Mol. Cell8:1303-1312(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 248-465;PHOSPHORYLATION AT SER-463 AND SER-465;SUBUNIT;MUTAGENESIS OF ASP-297; VAL-317; LYS-373; LYS-418; TYR-424; ARG-426 AND ASP-448

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