Smad1 ELISA Kit for Mouse(Mus musculus) | EIAab.comSmad1 ELISA Kit for Mouse(Mus musculus)

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Index > Protein center > Smad1(Gene name) > Mouse

Smad1 (Gene name),

Mothers against decapentaplegic homolog 1 (Protein name ), SMAD1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Smad1(Madh1;Madr1);

Protein name:

Mothers against decapentaplegic homolog 1(MAD homolog 1;Mothers against DPP homolog 1);

Alternative:

Mothers-against-DPP-related 1(Mad-related protein 1;mMad1);Dwarfin-A(Dwf-A);SMAD family member 1(SMAD 1;Smad1);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

May form trimers with another SMAD1 and the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit, CREB-binding protein (CBP), p300, SMURF1, SMURF2 and HOXC8. Associates with ZNF423 or ZNF521 in response to BMP2 leading to activate transcription of BMP target genes. Interacts with SKOR1. Interacts (via MH2 domain) with LEMD3. Binding to LEMD3 results in at least a partial reduction of receptor-mediated phosphorylation (By similarity). Also interacts with HGS, NANOG and ZCCHC12. Forms a ternary complex with PSMB4 and OAZ1 before PSMB4 is incorporated into the 20S proteasome.

Function:

Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD) (By similarity). May play a role in the initiation and maintenance of spermatogenesis. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.

Subcellular Location:

Cytoplasm Nucleus In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4. Co-localizes with LEMD3 at the nucleus inner membrane.

Protein Attributes:

Sequence length:

465

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

465:

LTQMGSPHNP | ISSVS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P70340

KEGG:

mmu:17125

SMR:

P70340

Pfam:

PF03165

UniGene:

Mm.223717

Uniprot:

P70340

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ELISA Kit for Mouse MAD homolog 1

Cat.:

E0647h

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96T

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ELISA Kit for Mouse MAD homolog 1

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E0647b

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96T

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ELISA Kit for Mouse MAD homolog 1

Cat.:

E0647m

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96T

ELISA Kit for Mouse MAD homolog 1

Cat.:

E0647r

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96T

CLIA Kit for Mouse MAD homolog 1

Cat.:

U0647m

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96T

CLIA Kit for Mouse MAD homolog 1

Cat.:

U0647r

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96T

CLIA Kit for Mouse MAD homolog 1

Cat.:

U0647h

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96T

CLIA Kit for Mouse MAD homolog 1

Cat.:

U0647b

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96T

Polyclonal Antibody for Mouse MAD homolog 1

Cat.:

P0647Rb-m

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40ug/0.2ml

Polyclonal Antibody for Mouse MAD homolog 1

Cat.:

P0647Rb-r

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Polyclonal Antibody for Mouse MAD homolog 1

Cat.:

P0647Rb-h

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Monoclonal Antibody for Mouse MAD homolog 1

Protein for Mouse MAD homolog 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth."
Yingling J.M. , Das P. , Savage C. , Zhang M. , Padgett R.W. , Wang X.-F.
Proc. Natl. Acad. Sci. U.S.A.93:8940-8944(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Embryo.
2.

"Evidence that Mothers-against-dpp-related 1 (Madr1) plays a role in the initiation and maintenance of spermatogenesis in the mouse."
Zhao G.-Q. , Hogan B.L.M.
Mech. Dev.61:63-73(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Embryonic heart.
3.

"Characterization of the mouse Smad1 gene and its expression pattern in adult mouse tissues."
Huang S. , Flanders K.C. , Roberts A.B.
Gene258:43-53(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain: 129/Sv.
4.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
tissue: Embryo.
tissue: Oviduct.
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6.
tissue: Brain.
6.

"Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA."
Miura S. , Takeshita T. , Asao H. , Kimura Y. , Murata K. , Sasaki Y. , Hanai J. , Beppu H. , Tsukazaki T. , Wrana J.L. , Miyazono K. , Sugamura K.
Mol. Cell. Biol.20:9346-9355(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HGS
7.

"SMAD-mediated modulation of YY1 activity regulates the BMP response and cardiac-specific expression of a GATA4/5/6-dependent chick Nkx2.5 enhancer."
Lee K.H. , Evans S. , Ruan T.Y. , Lassar A.B.
Development131:4709-4723(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION IN A COMPLEX WITH SMAD4 AND YY1
8.

"Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells."
Suzuki A. , Raya A. , Kawakami Y. , Morita M. , Matsui T. , Nakashima K. , Gage F.H. , Rodriguez-Esteban C. , Izpisua Belmonte J.C.
Proc. Natl. Acad. Sci. U.S.A.103:10294-10299(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NANOG
9.

"Sizn1 is a novel protein that functions as a transcriptional coactivator of bone morphogenic protein signaling."
Cho G. , Lim Y. , Zand D. , Golden J.A.
Mol. Cell. Biol.28:1565-1572(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ZCCHC12
10.

"Structure of Smad1 MH1/DNA complex reveals distinctive rearrangements of BMP and TGF-beta effectors."
Baburajendran N. , Palasingam P. , Narasimhan K. , Sun W. , Prabhakar S. , Jauch R. , Kolatkar P.R.
Nucleic Acids Res.38:3477-3488(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 9-132 IN COMPLEX WITH DNA;ZINC_BINDING SITES;SUBUNIT

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