Smad1 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comSmad1 ELISA Kit for Rat(Rattus norvegicus)

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Index > Protein center > Smad1(Gene name) > Rat

Smad1 (Gene name),

Mothers against decapentaplegic homolog 1 (Protein name ), SMAD1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Smad1(Mad1;Madh1);

Protein name:

Mothers against decapentaplegic homolog 1(MAD homolog 1;Mothers against DPP homolog 1);

Alternative:

SMAD family member 1(SMAD 1;Smad1);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

May form trimers with another SMAD1 and the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit, CREB-binding protein (CBP), NANOG, p300, SMURF1, SMURF2, HOXC8 and HGS. Associates with ZNF423 or ZNF521 in response to BMP2 leading to activate transcription of BMP target genes. Interacts with SKOR1 and ZCCHC12. Interacts (via MH2 domain) with LEMD3. Binding to LEMD3 results in at least a partial reduction of receptor-mediated phosphorylation (By similarity). Forms a ternary complex with PSMB4 and OAZ1 before PSMB4 is incorporated into the 20S proteasome.

Function:

Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD) (By similarity). Has been shown to be also activated by TGF-beta (transforming growth factor) type I receptor kinase in rat intestinal epithelial cells (IEC 4-1). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.

Subcellular Location:

Cytoplasm Nucleus In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4. Co-localizes with LEMD3 at the nucleus inner membrane.

Protein Attributes:

Sequence length:

468

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

468:

DKVLTQMGSP | HNPISSVS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P97588

UniGene:

Rn.10635

STRING:

10116.ENSRNOP00000025079

SMR:

P97588

Pfam:

PF03165

Uniprot:

P97588

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ELISA Kit for Rat MAD homolog 1

Cat.:

E0647h

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96T

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ELISA Kit for Rat MAD homolog 1

Cat.:

E0647b

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96T

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ELISA Kit for Rat MAD homolog 1

Cat.:

E0647m

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MSDS:

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96T

ELISA Kit for Rat MAD homolog 1

Cat.:

E0647r

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96T

CLIA Kit for Rat MAD homolog 1

Cat.:

U0647m

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MSDS:

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Packing:

96T

CLIA Kit for Rat MAD homolog 1

Cat.:

U0647r

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MSDS:

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Packing:

96T

CLIA Kit for Rat MAD homolog 1

Cat.:

U0647h

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MSDS:

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Packing:

96T

CLIA Kit for Rat MAD homolog 1

Cat.:

U0647b

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MSDS:

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Packing:

96T

Polyclonal Antibody for Rat MAD homolog 1

Cat.:

P0647Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat MAD homolog 1

Cat.:

P0647Rb-r

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40ug/0.2ml

Polyclonal Antibody for Rat MAD homolog 1

Cat.:

P0647Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Rat MAD homolog 1

Protein for Rat MAD homolog 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Regulation of transforming growth factor beta- and activin-induced transcription by mammalian Mad proteins."
Chen Y. , Lebrun J.-J. , Vale W.W.
Proc. Natl. Acad. Sci. U.S.A.93:12992-12997(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Brain.
2.

"Cloning and expression of a rat Smad1: regulation by TGFbeta and modulation by the Ras/MEK pathway."
Yue J. , Hartsough M.T. , Frey R.S. , Frielle T. , Mulder K.M.
J. Cell. Physiol.178:387-396(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Intestine.

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