SMAD2 ELISA Kit for Human(Homo sapiens) | EIAab.comSMAD2 ELISA Kit for Human(Homo sapiens)

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SMAD2 (Gene name),

Mothers against decapentaplegic homolog 2 (Protein name ), SMAD2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

SMAD2(MADH2;MADR2);

Protein name:

Mothers against decapentaplegic homolog 2(MAD homolog 2;Mothers against DPP homolog 2);

Alternative:

Mad-related protein 2(hMAD-2);JV18-1;SMAD family member 2(SMAD 2;Smad2;hSMAD2);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Momomer; the absence of TGF-beta. Heterodimer; in the presence of TGF-beta. Forms a heterodimer with co-SMAD, SMAD4, in the nucleus to form the transactivation complex SMAD2/SMAD4. Interacts with AIP1, HGS, PML and WWP1 (By similarity). Interacts with NEDD4L in response to TGF-beta (By similarity). Found in a complex with SMAD3 and TRIM33 upon addition of TGF-beta. Interacts with ACVR1B, SMAD3 and TRIM33. Interacts (via the MH2 domain) with ZFYVE9; may form trimers with the SMAD4 co-SMAD. Interacts with FOXH1, homeobox protein TGIF, PEBP2-alpha subunit, CREB-binding protein (CBP), EP300 and SKI. Interacts with SNON; when phosphorylated at Ser-465/467. Interacts with SKOR1 and SKOR2. Interacts with PRDM16. Interacts (via MH2 domain) with LEMD3. Interacts with RBPMS. Interacts with WWP1. Interacts (dephosphorylated form, via the MH1 and MH2 domains) with RANBP3 (via its C-terminal R domain); the interaction results in the export of dephosphorylated SMAD3 out of the nucleus and termination ot the TGF-beta signaling.

Function:

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma.

Subcellular Location:

Cytoplasm Nucleus Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4. On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1.

Protein Attributes:

Sequence length:

467

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

467:

KVLTQMGSPS | VRCSSMS

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000262160

KEGG:

hsa:4087

UniGene:

Hs.12253

String:

Q15796

MIM:

601366

Pfam:

PF03165

SMR:

Q15796

Uniprot:

Q15796

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ELISA Kit for Human MAD homolog 2

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E2184h

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ELISA Kit for Human MAD homolog 2

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E2184r

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96T

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ELISA Kit for Human MAD homolog 2

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E2184b

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96T

ELISA Kit for Human MAD homolog 2

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E2184m

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96T

CLIA Kit for Human MAD homolog 2

Cat.:

U2184b

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96T

CLIA Kit for Human MAD homolog 2

Cat.:

U2184r

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96T

CLIA Kit for Human MAD homolog 2

Cat.:

U2184m

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96T

CLIA Kit for Human MAD homolog 2

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U2184h

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96T

Polyclonal Antibody for Human MAD homolog 2

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P2184Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human MAD homolog 2

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P2184Rb-h

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Polyclonal Antibody for Human MAD homolog 2

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P2184Rb-r

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Polyclonal Antibody for Human MAD homolog 2

Monoclonal Antibody for Human MAD homolog 2

Protein for Human MAD homolog 2

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Mad-related genes in the human."
Riggins G.J. , Thiagalingam S. , Rosenblum E. , Weinstein C.L. , Kern S.E. , Hamilton S.R. , Willson J.K.V. , Markowitz S.D. , Kinzler K.W. , Vogelstein B.V.
Nat. Genet.13:347-349(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG);VARIANT 344-GLU--GLN-358 DEL
2.

"Receptor-associated Mad homologues synergize as effectors of the TGF-beta response."
Zhang Y. , Feng X.-H. , Wu R.-Y. , Derynck R.
Nature383:168-172(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)
tissue: Placenta.
3.

"MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma."
Eppert K. , Scherer S.W. , Ozcelik H. , Pirone R. , Hoodless P. , Kim H. , Tsui L.-C. , Bapat B. , Gallinger S. , Andrulis I.L. , Thomsen G.H. , Wrana J.L. , Attisano L.
Cell86:543-552(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG);PHOSPHORYLATION BY TGFBR1;VARIANTS CYS-133; ARG-440; HIS-445 AND GLU-450
tissue: Kidney.
4.

"Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes."
Liu F. , Pouponnot C. , Massague J.
Genes Dev.11:3157-3167(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)
5.

"Characterization of the MADH2/Smad2 gene, a human Mad homolog responsible for the transforming growth factor-beta and activin signal transduction pathway."
Takenoshita S. , Mogi A. , Nagashima M. , Yang K. , Yagi K. , Hanyu A. , Nagamachi Y. , Miyazono K. , Hagiwara K.
Genomics48:1-11(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS LONG AND SHORT)
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG)
tissue: Kidney.
tissue: Pancreas.
tissue: Spleen.
7.

Bienvenut W.V. , von Kriegsheim A. , Kolch W.
Submitted (2008-12) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-14 AND 170-182;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Chronic myeloid leukemia cell.
8.

"MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling."
Macias-Silva M. , Abdollah S. , Hoodless P.A. , Pirone R. , Attisano L. , Wrana J.L.
Cell87:1215-1224(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TGFBR1;PHOSPHORYLATION AT SER-464; SER-465 AND SER-467;MUTAGENESIS OF SER-464; SER-465 AND SER-467
9.

"SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor."
Tsukazaki T. , Chiang T.A. , Davison A.F. , Attisano L. , Wrana J.L.
Cell95:779-791(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ZFYVE9;SUBCELLULAR LOCATION
10.

"Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors."
Kawabata M. , Inoue H. , Hanyu A. , Imamura T. , Miyazono K.
EMBO J.17:4056-4065(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
11.

"Alternatively spliced variant of Smad2 lacking exon 3. Comparison with wild-type Smad2 and Smad3."
Yagi K. , Goto D. , Hamamoto T. , Takenoshita S. , Kato M. , Miyazono K.
J. Biol. Chem.274:703-709(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORMS LONG AND SHORT)
12.

"The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase."
Kretzschmar M. , Liu F. , Hata A. , Doody J. , Massague J.
Genes Dev.11:984-995(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-465 AND SER-467
13.

"TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling."
Abdollah S. , Macias-Silva M. , Tsukazaki T. , Hayashi H. , Attisano L. , Wrana J.L.
J. Biol. Chem.272:27678-27685(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-465 AND SER-467 BY TGFBR1
14.

"Characterization of human FAST-1, a TGF beta and activin signal transducer."
Zhou S. , Zawel L. , Lengauer C. , Kinzler K.W. , Vogelstein B.
Mol. Cell2:121-127(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FOXH1
tissue: Colon adenocarcinoma.
15.

"Roles of pathway-specific and inhibitory Smads in activin receptor signaling."
Lebrun J.J. , Takabe K. , Chen Y. , Vale W.
Mol. Endocrinol.13:15-23(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ACVR1B;FUNCTION
16.

"The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway."
Hocevar B.A. , Smine A. , Xu X.X. , Howe P.H.
EMBO J.20:2789-2801(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DAB2
17.

"Ski-interacting protein interacts with Smad proteins to augment transforming growth factor-beta-dependent transcription."
Leong G.M. , Subramaniam N. , Figueroa J. , Flanagan J.L. , Hayman M.J. , Eisman J.A. , Kouzmenko A.P.
J. Biol. Chem.276:18243-18248(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SNW1
18.

"TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation."
Bonni S. , Wang H.R. , Causing C.G. , Kavsak P. , Stroschein S.L. , Luo K. , Wrana J.L.
Nat. Cell Biol.3:587-595(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SMURF2;MUTAGENESIS OF 221-PRO--TYR-225
19.

"Decorin suppresses transforming growth factor-beta-induced expression of plasminogen activator inhibitor-1 in human mesangial cells through a mechanism that involves Ca2+-dependent phosphorylation of Smad2 at serine-240."
Abdel-Wahab N. , Wicks S.J. , Mason R.M. , Chantry A.
Biochem. J.362:643-649(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-240
20.

"Modulation of Smad2-mediated signaling by extracellular signal-regulated kinase."
Funaba M. , Zimmerman C.M. , Mathews L.S.
J. Biol. Chem.277:41361-41368(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-8; THR-220; SER-245; SER-250 AND SER-255
21.

"MAN1, an integral protein of the inner nuclear membrane, binds Smad2 and Smad3 and antagonizes transforming growth factor-beta signaling."
Lin F. , Morrison J.M. , Wu W. , Worman H.J.
Hum. Mol. Genet.14:437-445(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LEMD3
22.

"The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-{beta} superfamily of cytokines."
Pan D. , Estevez-Salmeron L.D. , Stroschein S.L. , Zhu X. , He J. , Zhou S. , Luo K.
J. Biol. Chem.280:15992-16001(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LEMD3
23.

"Cloning and functional characterization of a new Ski homolog, Fussel-18, specifically expressed in neuronal tissues."
Arndt S. , Poser I. , Schubert T. , Moser M. , Bosserhoff A.-K.
Lab. Invest.85:1330-1341(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SKOR2
24.

"PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling."
Lin X. , Duan X. , Liang Y.Y. , Su Y. , Wrighton K.H. , Long J. , Hu M. , Davis C.M. , Wang J. , Brunicardi F.C. , Shi Y. , Chen Y.G. , Meng A. , Feng X.H.
Cell125:915-928(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PPM1A;DEPHOSPHORYLATION;FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF VAL-398; SER-465 AND SER-467
25.

"Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway."
He W. , Dorn D.C. , Erdjument-Bromage H. , Tempst P. , Moore M.A. , Massague J.
Cell125:929-941(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH SMAD3 AND TRIM33;INTERACTION WITH TRIM33
26.

"The DNA binding activities of Smad2 and Smad3 are regulated by coactivator-mediated acetylation."
Simonsson M. , Kanduri M. , Gronroos E. , Heldin C.H. , Ericsson J.
J. Biol. Chem.281:39870-39880(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION AT LYS-19;MUTAGENESIS OF LYS-19 AND LYS-20
27.

"Potentiation of Smad-mediated transcriptional activation by the RNA-binding protein RBPMS."
Sun Y. , Ding L. , Zhang H. , Han J. , Yang X. , Yan J. , Zhu Y. , Li J. , Song H. , Ye Q.
Nucleic Acids Res.34:6314-6326(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RBPMS
28.

"3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins."
Seong H.A. , Jung H. , Kim K.T. , Ha H.
J. Biol. Chem.282:12272-12289(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION BY PDPK1;INTERACTION WITH PDPK1
29.

"Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling."
Arndt S. , Poser I. , Moser M. , Bosserhoff A.-K.
Mol. Cell. Neurosci.34:603-611(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SKOR1
30.

"Smad3 is acetylated by p300/CBP to regulate its transactivation activity."
Inoue Y. , Itoh Y. , Abe K. , Okamoto T. , Daitoku H. , Fukamizu A. , Onozaki K. , Hayashi H.
Oncogene26:500-508(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION;FUNCTION
31.

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-8;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
32.

"TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal."
Varelas X. , Sakuma R. , Samavarchi-Tehrani P. , Peerani R. , Rao B.M. , Dembowy J. , Yaffe M.B. , Zandstra P.W. , Wrana J.L.
Nat. Cell Biol.10:837-848(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH WWTR1
33.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-458;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
34.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
35.

"Nuclear export of Smad2 and Smad3 by RanBP3 facilitates termination of TGF-beta signaling."
Dai F. , Lin X. , Chang C. , Feng X.H.
Dev. Cell16:345-357(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RANBP3;SUBCELLULAR LOCATION;FUNCTION;MUTAGENESIS OF 465-SER--SER-467
36.

"SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells."
Takahata M. , Inoue Y. , Tsuda H. , Imoto I. , Koinuma D. , Hayashi M. , Ichikura T. , Yamori T. , Nagasaki K. , Yoshida M. , Matsuoka M. , Morishita K. , Yuki K. , Hanyu A. , Miyazawa K. , Inazawa J. , Miyazono K. , Imamura T.
J. Biol. Chem.284:3334-3344(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PRDM16
37.

"TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling."
Watanabe Y. , Itoh S. , Goto T. , Ohnishi E. , Inamitsu M. , Itoh F. , Satoh K. , Wiercinska E. , Yang W. , Shi L. , Tanaka A. , Nakano N. , Mommaas A.M. , Shibuya H. , Ten Dijke P. , Kato M.
Mol. Cell37:123-134(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PMEPA1;MUTAGENESIS OF TRP-368
38.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-8; SER-458 AND SER-460;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
39.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
40.

"ZNF580, a novel C2H2 zinc-finger transcription factor, interacts with the TGF-beta signal molecule Smad2."
Luo Y. , Hu W. , Xu R. , Hou B. , Zhang L. , Zhang W.
Cell Biol. Int.35:1153-1157(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ZNF580;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
41.

"USP15 is a deubiquitylating enzyme for receptor-activated SMADs."
Inui M. , Manfrin A. , Mamidi A. , Martello G. , Morsut L. , Soligo S. , Enzo E. , Moro S. , Polo S. , Dupont S. , Cordenonsi M. , Piccolo S.
Nat. Cell Biol.13:1368-1375(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;DEUBIQUITINATION BY USP15;DNA-BINDING;INTERACTION WITH USP15
42.

"Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-? pathway."
Bruce D.L. , Macartney T. , Yong W. , Shou W. , Sapkota G.P.
Cell. Signal.24:1999-2006(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PPP5C;SUBCELLULAR LOCATION
43.

"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
44.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
45.

"CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration."
Abbas T. , Mueller A.C. , Shibata E. , Keaton M. , Rossi M. , Dutta A.
Mol. Cell49:1147-1158(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-465 AND SER-467
46.

"C18 ORF1, a novel negative regulator of transforming growth factor-beta signaling."
Nakano N. , Maeyama K. , Sakata N. , Itoh F. , Akatsu R. , Nakata M. , Katsu Y. , Ikeno S. , Togawa Y. , Vo Nguyen T.T. , Watanabe Y. , Kato M. , Itoh S.
J. Biol. Chem.289:12680-12692(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LDLRAD4
47.

"TGF-beta signal transduction."
Massague J.
Annu. Rev. Biochem.67:753-791(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
48.

"Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells."
Verschueren K. , Huylebroeck D.
Cytokine Growth Factor Rev.10:187-199(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
49.

"The Smad pathway."
Wrana J.L. , Attisano L.
Cytokine Growth Factor Rev.11:5-13(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
50.

"TGF-beta signaling by Smad proteins."
Miyazono K.
Cytokine Growth Factor Rev.11:15-22(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
51.

"Structural basis of Smad2 recognition by the Smad anchor for receptor activation."
Wu G. , Chen Y.-G. , Ozdamar B. , Gyuricza C.A. , Chong P.A. , Wrana J.L. , Massague J. , Shi Y.
Science287:92-97(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 261-456 IN COMPLEX WITH ZFYVE9;INTERACTION WITH SARA;MUTAGENESIS OF ASN-381
52.

"Structural basis of heteromeric smad protein assembly in TGF-beta signaling."
Chacko B.M. , Qin B.Y. , Tiwari A. , Shi G. , Lam S. , Hayward L.J. , De Caestecker M. , Lin K.
Mol. Cell15:813-823(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 270-466 IN COMPLEX WITH SMAD4;SUBUNIT
53.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-300

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