Smad2 ELISA Kit for Mouse(Mus musculus) | EIAab.comSmad2 ELISA Kit for Mouse(Mus musculus)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > Smad2(Gene name) > Mouse

Smad2 (Gene name),

Mothers against decapentaplegic homolog 2 (Protein name ), SMAD2_MOUSE from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

Smad2(Madh2;Madr2);

Protein name:

Mothers against decapentaplegic homolog 2(MAD homolog 2;Mothers against DPP homolog 2);

Alternative:

SMAD family member 2(SMAD 2;Smad2);Mad-related protein 2(mMad2);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Momomer; the absence of TGF-beta (By similarity). Heterodimer; in the presence of TGF-beta. Forms a heterodimer with co-SMAD, SMAD4, in the nucleus to form the transactivation complex SMAD2/SMAD4 (By similarity). Found in a complex with SMAD3 and TRIM33 upon addition of TGF-beta. Interacts with ACVR1B, SMAD3 and TRIM33. Interacts (via the MH2 domain) with ZFYVE9; may form trimers with the SMAD4 co-SMAD. Interacts with FOXH1, homeobox protein TGIF, PEBP2-alpha subunit, CREB-binding protein (CBP), EP300 and SKI. Interacts with SNON; when phosphorylated at Ser-465/467. Interacts (via PY-motif) with SMURF2. Interacts with SKOR1 and SKOR2. Interacts with PRDM16. Interacts (via MH2 domain) with LEMD3. Interacts with RBPMS. Interacts (dephosphorylated form, via the MH1 and MH2 domains) with RANBP3 (via its C-terminal R domain); the interaction results in the export of dephosphorylated SMAD3 out of the nucleus and termination ot the TGF-beta signaling (By similarity). Interacts with NEDD4L in response to TGF-beta. Interacts with WWP1, AIP1 and HGS. Interacts with PML.

Function:

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma.

Subcellular Location:

Cytoplasm Nucleus Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4. On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1.

Protein Attributes:

Sequence length:

467

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

467:

KVLTQMGSPS | VRCSSMS

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

SMR:

Q62432

UniGene:

Mm.391091

String:

Q62432

UniGene:

Mm.152699

Pfam:

PF03165

KEGG:

mmu:17126

Uniprot:

Q62432

FOR

ELISA Kit for Mouse MAD homolog 2

Cat.:

E2184h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Mouse MAD homolog 2

Cat.:

E2184r

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Mouse MAD homolog 2

Cat.:

E2184b

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Mouse MAD homolog 2

Cat.:

E2184m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse MAD homolog 2

Cat.:

U2184b

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse MAD homolog 2

Cat.:

U2184r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse MAD homolog 2

Cat.:

U2184m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse MAD homolog 2

Cat.:

U2184h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Mouse MAD homolog 2

Cat.:

P2184Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse MAD homolog 2

Cat.:

P2184Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse MAD homolog 2

Cat.:

P2184Rb-r

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse MAD homolog 2

Monoclonal Antibody for Mouse MAD homolog 2

Protein for Mouse MAD homolog 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway."
Baker J.C. , Harland R.M.
Genes Dev.10:1880-1889(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)
strain: 129/Sv.
2.

"Smad4 (homolog of human DPC4) and Smad2 (homolog of human JV18-1): candidates for murine lung tumor resistance and suppressor genes."
Devereux T.R. , Anna C.H. , Patel A.C. , White C.M. , Festing M.F. , You M.
Carcinogenesis18:1751-1755(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)
strain: A/J.
strain: BALB/c.
3.

"Both SMAD2 and SMAD3 mediate activin-stimulated expression of the follicle-stimulating hormone beta subunit in mouse gonadotrope cells."
Bernard D.J.
Mol. Endocrinol.18:606-623(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT)
4.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG)
strain: C57BL/6J.
tissue: Pancreas.
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG)
6.

"Functions of mammalian Smad genes as revealed by targeted gene disruption in mice."
Weinstein M. , Yang X. , Deng C.-X.
Cytokine Growth Factor Rev.11:49-58(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
7.

"Cytoplasmic PML function in TGF-beta signalling."
Lin H.K. , Bergmann S. , Pandolfi P.P.
Nature431:205-211(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION;INTERACTION WITH PML AND ZFYVE9/SARA
8.

"Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1)."
Komuro A. , Imamura T. , Saitoh M. , Yoshida Y. , Yamori T. , Miyazono K. , Miyazawa K.
Oncogene23:6914-6923(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH WWP1
9.

"Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertile."
Dunn N.R. , Koonce C.H. , Anderson D.C. , Islam A. , Bikoff E.K. , Robertson E.J.
Genes Dev.19:152-163(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORM SHORT)
10.

"Transforming growth factor-beta 1 inhibits non-pathogenic Gram negative bacteria-induced NF-kappa B recruitment to the interleukin-6 gene promoter in intestinal epithelial cells through modulation of histone acetylation."
Haller D. , Holt L. , Kim S.C. , Schwabe R.F. , Sartor R.B. , Jobin C.
J. Biol. Chem.278:23851-23860(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-465 AND SER-467
11.

"Identification and characterization of a PDZ protein that interacts with activin types II receptors."
Shoji H. , Tsuchida K. , Kishi H. , Yamakawa N. , Matsuzaki T. , Liu Z. , Nakamura T. , Sugino H.
J. Biol. Chem.275:5485-5492(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AIP1
12.

"Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA."
Miura S. , Takeshita T. , Asao H. , Kimura Y. , Murata K. , Sasaki Y. , Hanai J. , Beppu H. , Tsukazaki T. , Wrana J.L. , Miyazono K. , Sugamura K.
Mol. Cell. Biol.20:9346-9355(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HGS
13.

"NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor."
Kuratomi G. , Komuro A. , Goto K. , Shinozaki M. , Miyazawa K. , Miyazono K. , Imamura T.
Biochem. J.386:461-470(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NEDD4L;UBIQUITINATION
14.

"Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-? pathway."
Bruce D.L. , Macartney T. , Yong W. , Shou W. , Sapkota G.P.
Cell. Signal.24:1999-2006(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PPP5C;SUBCELLULAR LOCATION

Product Feedback Wall

* Email:
*Comments: