Protein name:
Mothers against decapentaplegic homolog 2 (MAD homolog 2;Mothers against DPP homolog 2) ;
Alternative:
SMAD family member 2 (SMAD 2;Smad2) ;Mad-related protein 2 ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Momomer; the absence of TGF-beta (By similarity). Heterodimer; in the presence of TGF-beta. Forms a heterodimer with co-SMAD, SMAD4, in the nucleus to form the transactivation complex SMAD2/SMAD4 (By similarity). Found in a complex with SMAD3 and TRIM33 upon addition of TGF-beta. Interacts with ACVR1B, SMAD3 and TRIM33. Interacts (via the MH2 domain) with ZFYVE9; may form trimers with the SMAD4 co-SMAD. Interacts with FOXH1, homeobox protein TGIF, PEBP2-alpha subunit, CREB-binding protein (CBP), EP300 and SKI. Interacts with SNON; when phosphorylated at Ser-465/467. Interacts (via PY-motif) with SMURF2. Interacts with AIP1 and HGS. Interacts with NEDD4L in response to TGF-beta. Interacts with SKOR1 and SKOR2. Interacts with PRDM16. Interacts (via MH2 domain) with LEMD3. Interacts with RBPMS. Interacts with WWP1. Interacts (dephosphorylated form, via the MH1 and MH2 domains) with RANBP3 (via its C-terminal R domain); the interaction results in the export of dephosphorylated SMAD3 out of the nucleus and termination ot the TGF-beta signaling. Interacts with PML.
Function:
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma.
Subcellular Location:
Cytoplasm
Nucleus
Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4. On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1.
Protein Attributes:
50:
MSSILPFTPP | VVKRLLGWKK | SAGGSGGAGG | GEQNGQEEKW | CEKAVKSLVK |
100:
KLKKTGRLDE | LEKAITTQNC | NTKCVTIPST | CSEIWGLSTA | NTVDQWDTTG |
150:
LYSFSEQTRS | LDGRLQVSHR | KGLPHVIYCR | LWRWPDLHSH | HELKAIENCE |
200:
YAFSLKKDEV | CVNPYHYQRV | ETPVLPPVLV | PRHTEILTEL | PPLDDYTHSI |
250:
PENTNFPAGI | EPQSNYIPET | PPPGYISEDG | ETSDQQLNQS | MDTGSPAELS |
300:
PTTLSPVNHS | LDLQPVTYSE | PAFWCSIAYY | ELNQRVGETF | HASQPSLTVD |
350:
GFTDPSNSER | FCLGLLSNVN | RNATVEMTRR | HIGRGVRLYY | IGGEVFAECL |
400:
SDSAIFVQSP | NCNQRYGWHP | ATVCKIPPGC | NLKIFNNQEF | AALLAQSVNQ |
450:
GFEAVYQLTR | MCTIRMSFVK | GWGAEYRRQT | VTSTPCWIEL | HLNGPLQWLD |
467:
KVLTQMGSPS | VRCSSMS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Bovine
Mouse
ELISA Kit for Rat MAD homolog 2
ELISA Kit for Rat MAD homolog 2
ELISA Kit for Rat MAD homolog 2
ELISA Kit for Rat MAD homolog 2
CLIA Kit for Rat MAD homolog 2
CLIA Kit for Rat MAD homolog 2
CLIA Kit for Rat MAD homolog 2
CLIA Kit for Rat MAD homolog 2
Polyclonal Antibody for Rat MAD homolog 2
Polyclonal Antibody for Rat MAD homolog 2
Polyclonal Antibody for Rat MAD homolog 2
Polyclonal Antibody for Rat MAD homolog 2
Monoclonal Antibody for Rat MAD homolog 2
Monoclonal Antibody for Rat MAD homolog 2
Monoclonal Antibody for Rat MAD homolog 2
Monoclonal Antibody for Rat MAD homolog 2
Protein for Rat MAD homolog 2
Protein for Rat MAD homolog 2
Protein for Rat MAD homolog 2
Protein for Rat MAD homolog 2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
Sprague-Dawley .
tissue :
Brain .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
3.
"Molecular cloning of rat Smad2 gene."
Miyakita A.
,
Okuno S.
,
Watanabe T.K.
,
Oga K.
,
Tsuji A.
,
Hishigaki H.
,
Kato S.
,
Sano A.
,
Suto T.
,
Nakagawa K.
,
Nakahara Y.
,
Haraguchi N.
,
Higashi K.
Submitted (1998-01) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Testis .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Brain .