Smad4 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comSmad4 ELISA Kit for Rat(Rattus norvegicus)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > Smad4(Gene name) > Rat

Smad4 (Gene name),

Mothers against decapentaplegic homolog 4 (Protein name ), SMAD4_RAT from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

Smad4(Madh4);

Protein name:

Mothers against decapentaplegic homolog 4(MAD homolog 4;Mothers against DPP homolog 4);

Alternative:

SMAD family member 4(SMAD 4;Smad4);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Monomer (By similarity). Heterotrimer; with a C-terminally phosphorylated R-SMAD molecule and to form the transcriptionally active SMAD2/3-SMAD4 complex (By similarity). Found in a ternary complex composed of SMAD4, STK11/LKB1 and STK11IP. Interacts with ATF2, COPS5, DACH1, MSG1, SKI, STK11/LKB1, STK11IP and TRIM33. Associates with ZNF423 or ZNF521 in response to BMP2 leading to activate transcription of BMP target genes. Interacts with USP9X. Interacts with RBPMS. Interacts with WWTR1 (via coiled-coil domain). Interacts with CITED1 (By similarity). Interacts with CITED2.

Function:

Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for syngernistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor.

Subcellular Location:

Cytoplasm Nucleus In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with R-SMAD.

Protein Attributes:

Sequence length:

552

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

552:

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

String:

O70437

UniGene:

Rn.9774

SMR:

O70437

STRING:

10116.ENSRNOP00000063487

KEGG:

rno:50554

Pfam:

PF03165

Uniprot:

O70437

FOR

ELISA Kit for Rat MAD homolog 4

MSDS:

Please sign in first.

ELISA Kit for Rat MAD homolog 4

Cat.:

E1925r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Rat MAD homolog 4

Cat.:

E1925b

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Rat MAD homolog 4

Cat.:

E1925m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Rat MAD homolog 4

Cat.:

E1925p

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Rat MAD homolog 4

Cat.:

U1925m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Rat MAD homolog 4

Cat.:

U1925b

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Rat MAD homolog 4

Cat.:

U1925h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Rat MAD homolog 4

Cat.:

U1925p

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Rat MAD homolog 4

Cat.:

U1925r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Rat MAD homolog 4

Cat.:

P1925Rb-r

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Rat MAD homolog 4

Cat.:

P1925Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Rat MAD homolog 4

Cat.:

P1925Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Rat MAD homolog 4

Protein for Rat MAD homolog 4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Molecular cloning of rat Smad4 gene."
Miyakita A. , Okuno S. , Watanabe T.K. , Oga K. , Tsuji A. , Hishigaki H. , Suto T. , Nakagawa K. , Nakahara Y. , Higashi K.
Submitted (1998-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Skeletal muscle.
2.

"cDNA cloning and chromosomal mapping of rat Smad2 and Smad4 and their expression in cultured rat articular chondrocytes."
Osaki M. , Tsukazaki T. , Ono N. , Yonekura A. , Hirota Y. , Miyazaki Y. , Shindo H. , Sonta S. , Yamashita S.
Endocr. J.46:695-701(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Cited2 modulates TGF-beta-mediated upregulation of MMP9."
Chou Y.T. , Wang H. , Chen Y. , Danielpour D. , Yang Y.C.
Oncogene25:5547-5560(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CITED2

Product Feedback Wall

* Email:
*Comments: