SMAD6 ELISA Kit for Human(Homo sapiens) | EIAab.comSMAD6 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > SMAD6(Gene name) > Human

SMAD6 (Gene name),

Mothers against decapentaplegic homolog 6 (Protein name ), SMAD6_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

SMAD6(MADH6);

Protein name:

Mothers against decapentaplegic homolog 6(MAD homolog 6;Mothers against DPP homolog 6);

Alternative:

SMAD family member 6(SMAD 6;Smad6;hSMAD6);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with NEDD4L (By similarity). Interacts with WWP1 (By similarity). Interacts with RNF111 and AXIN1. Interacts with TGF-beta type I receptor superfamily members, SMAD1, HOXC8 and HOXC9. Interacts with STAMBP and PRKX.

Function:

Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

496

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

496:

EPDAADGPYD | PNSVRISFAK | GWGPCYSRQF | ITSCPCWLEI | LLNNPR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.153863

String:

O43541

STRING:

9606.ENSP00000288840

SMR:

O43541

MIM:

602931

KEGG:

hsa:4091

Pfam:

PF03165

Uniprot:

O43541

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ELISA Kit for Human MAD homolog 6

Cat.:

E2187h

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Manual:

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MSDS:

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96T

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ELISA Kit for Human MAD homolog 6

Cat.:

E2187m

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MSDS:

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Packing:

96T

ELISA Kit for Human MAD homolog 6

Cat.:

E2187c

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MSDS:

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Packing:

96T

CLIA Kit for Human MAD homolog 6

Cat.:

U2187c

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MSDS:

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Packing:

96T

CLIA Kit for Human MAD homolog 6

Cat.:

U2187h

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MSDS:

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Packing:

96T

CLIA Kit for Human MAD homolog 6

Cat.:

U2187m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human MAD homolog 6

Cat.:

P2187Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human MAD homolog 6

Cat.:

P2187Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human MAD homolog 6

Monoclonal Antibody for Human MAD homolog 6

Protein for Human MAD homolog 6

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Mad-related genes in the human."
Riggins G.J. , Thiagalingam S. , Rosenblum E. , Weinstein C.L. , Kern S.E. , Hamilton S.R. , Willson J.K.V. , Markowitz S.D. , Kinzler K.W. , Vogelstein B.V.
Nat. Genet.13:347-349(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B)
2.

"Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor."
Hata A. , Lagna G. , Massague J. , Hemmati-Brivanlou A.
Genes Dev.12:186-197(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A);FUNCTION;INTERACTION WITH ACVR1B; BMPR1B; SMAD1 AND TGFBR1;MUTAGENESIS OF GLY-471 AND 478-ARG--ARG-496
tissue: T-cell.
3.

"Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members."
Afrakhte M. , Moren A. , Jossan S. , Itoh S. , Sampath K. , Westermark B. , Heldin C.H. , Heldin N.E. , ten Dijke P.
Biochem. Biophys. Res. Commun.249:505-511(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)
tissue: Placenta.
4.

Hagiwara K. , Freeman A.H. , McMenamin M.G. , Bennett W.P. , Nagashima M. , Minter A.R. , Yang K. , Takenoshita S. , Harris C.C.
Submitted (1998-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM A)
5.

"Identification of a new SMAD6 variant in human."
Konrad L. , Scheiber J.A. , Brandt H. , Eickelberg O. , Hofmann R.
Submitted (2007-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM D)
tissue: Prostatic carcinoma.
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A)
tissue: Uterus.
7.

"Determination of the genomic structure of human Smad3, Smad6 and Smad7 and the cloning of the human Smad3 promoter."
Hagiwara K. , Freeman A.A.H. , McMenamin M.G. , Bennett W.P. , Yang K. , Takenoshita S. , Harris C.C.
Submitted (1998-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM B)
8.

"TGF-beta signal transduction."
Massague J.
Annu. Rev. Biochem.67:753-791(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
9.

"Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells."
Verschueren K. , Huylebroeck D.
Cytokine Growth Factor Rev.10:187-199(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
10.

"The Smad pathway."
Wrana J.L. , Attisano L.
Cytokine Growth Factor Rev.11:5-13(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
11.

"TGF-beta signaling by Smad proteins."
Miyazono K.
Cytokine Growth Factor Rev.11:15-22(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
12.

"Smad6 as a transcriptional corepressor."
Bai S. , Shi X. , Yang X. , Cao X.
J. Biol. Chem.275:8267-8270(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HOXC8
13.

"Human truncated Smad 6 (Smad 6s) inhibits the BMP pathway in Xenopus laevis."
Krishnan P. , King M.W. , Neff A.W. , Sandusky G.E. , Bierman K.L. , Grinnell B. , Smith R.C.
Dev. Growth Differ.43:115-132(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION (ISOFORM B)
14.

"Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads."
Itoh F. , Asao H. , Sugamura K. , Heldin C.-H. , ten Dijke P. , Itoh S.
EMBO J.20:4132-4142(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STAMBP
15.

"Arkadia amplifies TGF-beta superfamily signaling through degradation of Smad7."
Koinuma D. , Shinozaki M. , Komuro A. , Goto K. , Saitoh M. , Hanyu A. , Ebina M. , Nukiwa T. , Miyazawa K. , Imamura T. , Miyazono K.
EMBO J.22:6458-6470(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RNF111
16.

"Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia."
Liu W. , Rui H. , Wang J. , Lin S. , He Y. , Chen M. , Li Q. , Ye Z. , Zhang S. , Chan S.C. , Chen Y.-G. , Han J. , Lin S.-C.
EMBO J.25:1646-1658(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AXIN1
17.

"Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1."
Choi K.C. , Lee Y.S. , Lim S. , Choi H.K. , Lee C.H. , Lee E.K. , Hong S. , Kim I.H. , Kim S.J. , Park S.H.
Nat. Immunol.7:1057-1065(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PELI1
18.

"Smad6 is a protein kinase X phosphorylation substrate and is required for HL-60 cell differentiation."
Glesne D. , Huberman E.
Oncogene25:4086-4098(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH PRKX;MUTAGENESIS OF SER-435;PHOSPHORYLATION AT SER-435
19.

"Nonsynonymous variants in the SMAD6 gene predispose to congenital cardiovascular malformation."
Tan H.L. , Glen E. , Topf A. , Hall D. , O'Sullivan J.J. , Sneddon L. , Wren C. , Avery P. , Lewis R.J. , ten Dijke P. , Arthur H.M. , Goodship J.A. , Keavney B.D.
Hum. Mutat.33:720-727(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CONGENITAL CARDIOVASCULAR MALFORMATIONS;VARIANT THR-325;VARIANTS AOVD2 LEU-415 AND PHE-484;CHARACTERIZATION OF VARIANTS AOVD2 LEU-415 AND PHE-484
20.

"Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6."
Zhang X. , Zhang J. , Bauer A. , Zhang L. , Selinger D.W. , Lu C.X. , Ten Dijke P.
EMBO J.32:996-1007(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION AT LYS-173;MUTAGENESIS OF LYS-173

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