Protein name:
Mothers against decapentaplegic homolog 6 (MAD homolog 6;Mothers against DPP homolog 6) ;
Alternative:
SMAD family member 6 (SMAD 6;Smad6;hSMAD6) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with NEDD4L (By similarity). Interacts with WWP1 (By similarity). Interacts with RNF111 and AXIN1. Interacts with TGF-beta type I receptor superfamily members, SMAD1, HOXC8 and HOXC9. Interacts with STAMBP and PRKX.
Function:
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MFRSKRSGLV | RRLWRSRVVP | DREEGGSGGG | GGGDEDGSLG | SRAEPAPRAR |
100:
EGGGCGRSEV | RPVAPRRPRD | AVGQRGAQGA | GRRRRAGGPP | RPMSEPGAGA |
150:
GSSLLDVAEP | GGPGWLPESD | CETVTCCLFS | ERDAAGAPRD | ASDPLAGAAL |
200:
EPAGGGRSRE | ARSRLLLLEQ | ELKTVTYSLL | KRLKERSLDT | LLEAVESRGG |
250:
VPGGCVLVPR | ADLRLGGQPA | PPQLLLGRLF | RWPDLQHAVE | LKPLCGCHSF |
300:
AAAADGPTVC | CNPYHFSRLC | GPESPPPPYS | RLSPRDEYKP | LDLSDSTLSY |
350:
TETEATNSLI | TAPGEFSDAS | MSPDATKPSH | WCSVAYWEHR | TRVGRLYAVY |
400:
DQAVSIFYDL | PQGSGFCLGQ | LNLEQRSESV | RRTRSKIGFG | ILLSKEPDGV |
450:
WAYNRGEHPI | FVNSPTLDAP | GGRALVVRKV | PPGYSIKVFD | FERSGLQHAP |
496:
EPDAADGPYD | PNSVRISFAK | GWGPCYSRQF | ITSCPCWLEI | LLNNPR
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Chicken
ELISA Kit for Human MAD homolog 6
ELISA Kit for Human MAD homolog 6
ELISA Kit for Human MAD homolog 6
CLIA Kit for Human MAD homolog 6
CLIA Kit for Human MAD homolog 6
CLIA Kit for Human MAD homolog 6
Polyclonal Antibody for Human MAD homolog 6
Polyclonal Antibody for Human MAD homolog 6
Polyclonal Antibody for Human MAD homolog 6
Monoclonal Antibody for Human MAD homolog 6
Monoclonal Antibody for Human MAD homolog 6
Monoclonal Antibody for Human MAD homolog 6
Protein for Human MAD homolog 6
Protein for Human MAD homolog 6
Protein for Human MAD homolog 6
R&D Technical Data
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Precision
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Recovery
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B)
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A);FUNCTION;INTERACTION WITH ACVR1B; BMPR1B; SMAD1 AND TGFBR1;MUTAGENESIS OF GLY-471 AND 478-ARG--ARG-496
tissue :
T-cell .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)
tissue :
Placenta .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM A)
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM D)
tissue :
Prostatic carcinoma .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A)
tissue :
Uterus .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM B)
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH HOXC8
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION (ISOFORM B)
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH STAMBP
15.
"Arkadia amplifies TGF-beta superfamily signaling through degradation of Smad7."
Koinuma D.
,
Shinozaki M.
,
Komuro A.
,
Goto K.
,
Saitoh M.
,
Hanyu A.
,
Ebina M.
,
Nukiwa T.
,
Miyazawa K.
,
Imamura T.
,
Miyazono K.
EMBO J.22:6458-6470(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH RNF111
16.
"Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia."
Liu W.
,
Rui H.
,
Wang J.
,
Lin S.
,
He Y.
,
Chen M.
,
Li Q.
,
Ye Z.
,
Zhang S.
,
Chan S.C.
,
Chen Y.-G.
,
Han J.
,
Lin S.-C.
EMBO J.25:1646-1658(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH AXIN1
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH PELI1
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH PRKX;MUTAGENESIS OF SER-435;PHOSPHORYLATION AT SER-435
19.
"Nonsynonymous variants in the SMAD6 gene predispose to congenital cardiovascular malformation."
Tan H.L.
,
Glen E.
,
Topf A.
,
Hall D.
,
O'Sullivan J.J.
,
Sneddon L.
,
Wren C.
,
Avery P.
,
Lewis R.J.
,
ten Dijke P.
,
Arthur H.M.
,
Goodship J.A.
,
Keavney B.D.
Hum. Mutat.33:720-727(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN CONGENITAL CARDIOVASCULAR MALFORMATIONS;VARIANT THR-325;VARIANTS AOVD2 LEU-415 AND PHE-484;CHARACTERIZATION OF VARIANTS AOVD2 LEU-415 AND PHE-484
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : UBIQUITINATION AT LYS-173;MUTAGENESIS OF LYS-173