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Index > Protein center > Smc2(Gene name) > Mouse
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  • Smc2 (Gene name),
  • Structural maintenance of chromosomes protein 2 (Protein name ),  SMC2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Smc2(Cape;Fin16;Smc2l1);
    Protein name:
    Structural maintenance of chromosomes protein 2(SMC protein 2;SMC-2);
    Alternative:
    FGF-inducible protein 16;Chromosome-associated protein E;XCAP-E homolog;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Forms an heterodimer with SMC4. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG.
    Function:
    Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
    Subcellular Location:
    Nucleus Cytoplasm Chromosome In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
    Protein Attributes:
    Sequence length:
    1191
    Sequence:
    50:
    MYVKSIILEG | FKSYAQRTEV | NGFDPLFNAI | TGLNGSGKSN | ILDSICFLLG | 
    100:
    ISNLSQVRAS | NLQDLVYKNG | QAGITKASVS | ITFDNSDKKQ | SPLGFEAHDE | 
    150:
    ITVTRQVVIG | GRNKYLINGV | NANNTRVQDL | FCSVGLNVNN | PHFLIMQGRI | 
    200:
    TKVLNMKPPE | ILSMIEEAAG | TRMYEYKKIA | AQKTIEKKEA | KLKEIKTILE | 
    250:
    EEITPTIQKL | KEERSSYLEY | QKVMREIEHL | SRLYIAYQFL | RAEDTKERSA | 
    300:
    GELKEMQDKI | VNLQEVLSEN | EKKIKALNCE | IEELERRKDK | ETGGKLKSLE | 
    350:
    DACAEAQRVN | TKSQSAFDLK | KKNLASEETK | RKELQNSMAE | DSKALAAKEK | 
    400:
    EVKKITDGLH | GLQEASNKDA | EALAAAQQHF | NAVSAGLSSN | EDGAEATLAG | 
    450:
    QMIACKNDIS | KAQTEAKQAQ | MKLKHAQQEL | KSKQAEVKKM | DSGYKKDQDA | 
    500:
    FEAVKKAKEK | LETEMKKLNY | EENKEEKLLE | KHRQLSRDIN | NLKGKHEALL | 
    550:
    AKFPNLQFAY | KDPEKNWNRN | SVKGLVASLI | NVKDNSTATA | LEVVAGERLY | 
    600:
    NVVVDTEVTA | KKLLEKGELK | RRYTIIPLNK | ISARCIAPET | LRVAQNLVGP | 
    650:
    DNVHVALSLV | DYKPELQKGM | EFVFGTTFVC | NNMDNAKKVA | FDKRIMTRTV | 
    700:
    TLGGDVFDPH | GTLSGGARSQ | AASILTKFQE | VKDVQDELRT | KENELRALEE | 
    750:
    ELAGLKNVAE | KYRQLKQQWE | MKTEEGDLLQ | TKLQQSSYHK | QQEELDALKK | 
    800:
    TIEESEETLK | STKEIQKKAE | EKYEALENKM | KNAEAEREKE | LKDAQKKLDC | 
    850:
    AKTKADASSK | KMKEKQQEVE | AITLELEELK | REHASNEQQL | DAVNEAIKAY | 
    900:
    EGQIEKMAAE | VAKNKESVNK | AQDELMKQKQ | IITAQDNIIK | DKCAEVAKHN | 
    950:
    LQNNESQLKI | KELDHSISKH | KREADDAAAK | VSKMLSDYDW | INAEKHLFGQ | 
    1000:
    PNSAYDFKTN | NPKEAGQRLQ | KLQEVKEKLG | RNVNLRAMNV | LTEAEERYND | 
    1050:
    LMKKKRIVEN | DKSKILATIE | DLDQKKNQAL | NIAWQKVNKD | FGSIFSTLLP | 
    1100:
    GANAMLAPPE | GQTVLDGLEF | KVALGNTWKE | NLTELSGGQR | SLVALSLILS | 
    1150:
    MLLFKPAPIY | ILDEVDAALD | LSHTQNIGQM | LRTHFTHSQF | IVVSLKEGMF | 
    1191:
    NNANVLFKTK | FVDGVSTVAR | FTQSQAGKIP | KEAKSRGKEP | N
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    SMR:
    UniGene:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse SMC protein 2
    ELISA Kit for Mouse SMC protein 2
    ELISA Kit for Mouse SMC protein 2
    CLIA Kit for Mouse SMC protein 2
    CLIA Kit for Mouse SMC protein 2
    CLIA Kit for Mouse SMC protein 2
    Polyclonal Antibody for Mouse SMC protein 2
    Polyclonal Antibody for Mouse SMC protein 2
    Polyclonal Antibody for Mouse SMC protein 2
    Monoclonal Antibody for Mouse SMC protein 2
    Monoclonal Antibody for Mouse SMC protein 2
    Monoclonal Antibody for Mouse SMC protein 2
    Protein for Mouse SMC protein 2
    Protein for Mouse SMC protein 2
    Protein for Mouse SMC protein 2

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    Linearity
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    References
    1. 1.
      "The evolution of SMC proteins: phylogenetic analysis and structural implications."
      Cobbe N. , Heck M.M.S.
      Mol. Biol. Evol.21:332-347(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-284
      strain: C57BL/6J.
      tissue: Embryo.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    4. 4.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
      tissue: Brain.
    6. 6.
      Lubec G. , Kang S.U.
      Submitted (2007-04) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 562-570;IDENTIFICATION BY MASS SPECTROMETRY
      strain: C57BL/6.
      tissue: Brain.
    7. 7.
      "Induction of expression of growth-related genes by FGF-4 in mouse fibroblasts."
      Guthridge M.A. , Seldin M. , Basilico C.
      Oncogene12:1267-1278(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 801-1191
    8. 8.
      "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
      Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1160;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
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