Smc3 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comSmc3 ELISA Kit for Rat(Rattus norvegicus)

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Smc3 (Gene name),

Structural maintenance of chromosomes protein 3 (Protein name ), SMC3_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Smc3(Bam;Bmh;Cspg6;Smc3l1);

Protein name:

Structural maintenance of chromosomes protein 3(SMC protein 3;SMC-3);

Alternative:

Chondroitin sulfate proteoglycan 6;Basement membrane-associated chondroitin proteoglycan(Bamacan);Chromosome segregation protein SmcD;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Forms a heterodimer with SMC1A or SMC1B in cohesin complexes. Cohesin complexes are composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domain, RAD21 which link them, and one STAG protein (STAG1, STAG2 or STAG3), which interacts with RAD21. Also found in meiosis-specific cohesin complexes. Interacts with NUMA1, and forms a ternary complex with KIF3B and KIFAP3, suggesting a function in tethering the chromosomes to the spindle pole and a function in chromosome movement. Interacts with MXI1, MXD3 and MXD4. Found in a complex with SMC1A, CDCA5 and RAD21, PDS5A/APRIN and PDS5B/SCC-112. Interacts with PDS5A and WAPAL; regulated by SMC3 acetylation (By similarity). Interacts with SYCP2.

Function:

Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement.

Subcellular Location:

Nucleus Chromosome Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation.

Protein Attributes:

Sequence length:

1191

Sequence:

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1050:

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1150:

1191:

AQHRKAVSDM | IMELAVHAQF | ITTTFRPELL | ESADKSSGKS | E

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF06470

UniGene:

Rn.11074

STRING:

10116.ENSRNOP00000019560

String:

P97690

Uniprot:

P97690

FOR

ELISA Kit for Rat SMC protein 3

CLIA Kit for Rat SMC protein 3

Polyclonal Antibody for Rat SMC protein 3

Monoclonal Antibody for Rat SMC protein 3

Protein for Rat SMC protein 3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"cDNA cloning of the basement membrane chondroitin sulfate proteoglycan core protein, bamacan: a five domain structure including coiled-coil motifs."
Wu R.-R. , Couchman J.R.
J. Cell Biol.136:433-444(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Yolk sac carcinoma.
2.

Lubec G. , Kang S.U. , Lubec S.
Submitted (2007-09) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 437-447 AND 462-469;IDENTIFICATION BY MASS SPECTROMETRY
strain: Sprague-Dawley.
tissue: Brain.
3.

"Association of mammalian SMC1 and SMC3 proteins with meiotic chromosomes and synaptonemal complexes."
Eijpe M. , Heyting C. , Gross B. , Jessberger R.
J. Cell Sci.113:673-682(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SYCP2

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