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Index > Protein center > SMTNL1(Gene name) > Human
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  • SMTNL1 (Gene name),
  • Smoothelin-like protein 1 (Protein name ),  SMTL1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    SMTNL1;
    Protein name:
    Smoothelin-like protein 1;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with PPP1R12A.
    Function:
    Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylation at Ser-299 reduces this inhibitory activity.
    Subcellular Location:
    Cytoplasm myofibril Cytoplasm myofibril sarcomere I band Cytoplasm myofibril sarcomere M line Nucleus Colocalizes with MYH2. In its unphosphorylated state, localizes to the cytoplasm (By similarity). Phosphorylation at Ser-301 promotes translocation to the nucleus.
    Protein Attributes:
    Sequence length:
    457
    Sequence:
    50:
    MEQKEGKLSE | DGTTVSPAAD | NPEMSGGGAP | AEETKGTAGK | AINEGPPTES | 
    100:
    GKQEKAPAED | GMSAELQGEA | NGLDEVKVES | QREAGGKEDA | EAELKKEDGE | 
    150:
    KEETTVGSQE | MTGRKEETKS | EPKEAEEKES | TLASEKQKAE | EKEAKPESGQ | 
    200:
    KADANDRDKP | EPKATVEEED | AKTASQEETV | VEDEAKAEPK | EPDGKEEAKH | 
    250:
    GAKEEADEPG | SPSEEQEQDV | EKEPEGGAGV | IPSSPEEWPE | SPTGEGHNLS | 
    300:
    TDGLGPDCVA | SGQTSPSASE | SSPSDVPQSP | PESPSSGEKK | EKAPERRVSA | 
    350:
    PARPRGPRAQ | NRKAIVDKFG | GAASGPTALF | RNTKAAGAAI | GGVKNMLLEW | 
    400:
    CRAMTKKYEH | VDIQNFSSSW | SSGMAFCALI | HKFFPDAFDY | AELDPAKRRH | 
    450:
    NFTLAFSTAE | KLADCAQLLD | VDDMVRLAVP | DSKCVYTYIQ | ELYRSLVQKG | 
    457:
    LVKTKKK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    Pfam:
    String:
    UniGene:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Smoothelin-like protein 1
    Cat.:
    E2278m
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Smoothelin-like protein 1
    Cat.:
    E2278h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Smoothelin-like protein 1
    Cat.:
    U2278h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Smoothelin-like protein 1
    Cat.:
    U2278m
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Smoothelin-like protein 1
    Cat.:
    P2278Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Smoothelin-like protein 1
    Cat.:
    P2278Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Smoothelin-like protein 1
    Monoclonal Antibody for Human Smoothelin-like protein 1
    Protein for Human Smoothelin-like protein 1
    Protein for Human Smoothelin-like protein 1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    2. 2.
      "Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle."
      Wooldridge A.A. , Fortner C.N. , Lontay B. , Akimoto T. , Neppl R.L. , Facemire C. , Datto M.B. , Kwon A. , McCook E. , Li P. , Wang S. , Thresher R.J. , Miller S.E. , Perriard J.C. , Gavin T.P. , Hickner R.C. , Coffman T.M. , Somlyo A.V. , more...
      J. Biol. Chem.283:11850-11859(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    3. 3.
      "Smoothelin-like 1 protein regulates myosin phosphatase-targeting subunit 1 expression during sexual development and pregnancy."
      Lontay B. , Bodoor K. , Weitzel D.H. , Loiselle D. , Fortner C. , Lengyel S. , Zheng D. , Devente J. , Hickner R. , Haystead T.A.
      J. Biol. Chem.285:29357-29366(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
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