Smtnl1 ELISA Kit for Mouse(Mus musculus) | EIAab.comSmtnl1 ELISA Kit for Mouse(Mus musculus)

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Smtnl1 (Gene name),

Smoothelin-like protein 1 (Protein name ), SMTL1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Smtnl1;

Protein name:

Smoothelin-like protein 1;

Alternative:

Calponin homology-associated smooth muscle protein(CHASM);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with PPP1R12A.

Function:

Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylation at Ser-301 reduces this inhibitory activity.

Subcellular Location:

Cytoplasm myofibril sarcomere I band Cytoplasm myofibril sarcomere M line Nucleus Colocalizes with MYH2. In its unphosphorylated state, localizes to the cytoplasm. Phosphorylation at Ser-301 promotes translocation to the nucleus.

Protein Attributes:

Sequence length:

459

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

459:

KGLVKTKKK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.33452

SMR:

Q99LM3

Pfam:

PF00307

String:

Q99LM3

KEGG:

mmu:68678

STRING:

10090.ENSMUSP00000028471

Uniprot:

Q99LM3

FOR

ELISA Kit for Mouse Smoothelin-like protein 1

Cat.:

E2278m

Price:

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MSDS:

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Packing:

96T

ELISA Kit for Mouse Smoothelin-like protein 1

Cat.:

E2278h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Smoothelin-like protein 1

Cat.:

U2278h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Smoothelin-like protein 1

Cat.:

U2278m

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Smoothelin-like protein 1

Cat.:

P2278Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Smoothelin-like protein 1

Cat.:

P2278Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Smoothelin-like protein 1

Protein for Mouse Smoothelin-like protein 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: FVB/N.
tissue: Mammary tumor.
3.

"Modulation of smooth muscle contractility by CHASM, a novel member of the smoothelin family of proteins."
Borman M.A. , MacDonald J.A. , Haystead T.A.
FEBS Lett.573:207-213(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-301;MUTAGENESIS OF SER-301
4.

"Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle."
Wooldridge A.A. , Fortner C.N. , Lontay B. , Akimoto T. , Neppl R.L. , Facemire C. , Datto M.B. , Kwon A. , McCook E. , Li P. , Wang S. , Thresher R.J. , Miller S.E. , Perriard J.C. , Gavin T.P. , Hickner R.C. , Coffman T.M. , Somlyo A.V. , more...
J. Biol. Chem.283:11850-11859(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;PHOSPHORYLATION AT SER-301;DISRUPTION PHENOTYPE;INDUCTION;MUTAGENESIS OF SER-301
5.

"Smoothelin-like 1 protein regulates myosin phosphatase-targeting subunit 1 expression during sexual development and pregnancy."
Lontay B. , Bodoor K. , Weitzel D.H. , Loiselle D. , Fortner C. , Lengyel S. , Zheng D. , Devente J. , Hickner R. , Haystead T.A.
J. Biol. Chem.285:29357-29366(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PPP1R12A;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;PHOSPHORYLATION AT SER-301;DEVELOPMENTAL STAGE;DISRUPTION PHENOTYPE;MUTAGENESIS OF SER-301
6.

"Solution structure of the calponin homology (CH) domain from the smoothelin-like 1 protein: a unique apocalmodulin-binding mode and the possible role of the C-terminal type-2 CH-domain in smooth muscle relaxation."
Ishida H. , Borman M.A. , Ostrander J. , Vogel H.J. , MacDonald J.A.
J. Biol. Chem.283:20569-20578(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 346-459;CALMODULIN BINDING

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