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Index > Protein center > SMURF1(Gene name) > Human
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  • SMURF1 (Gene name),
  • E3 ubiquitin-protein ligase SMURF1 (Protein name ),  SMUF1_HUMAN from NCBI database.
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  • General Annotation
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  • Gene name:
    SMURF1(KIAA1625);
    Protein name:
    E3 ubiquitin-protein ligase SMURF1(hSMURF1);
    Alternative:
    SMAD-specific E3 ubiquitin-protein ligase 1;SMAD ubiquitination regulatory factor 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with TRAF4. Interacts (via HECT domain) with FBXL15 (via LRR repeats). Interacts with SMAD7 and TGFBR1; SMAD7 recruits SMURF1 to TGFBR1 and regulates TGF-beta receptor degradation.
    Function:
    E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Acts by mediating ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    757
    Sequence:
    50:
    MSNPGTRRNG | SSIKIRLTVL | CAKNLAKKDF | FRLPDPFAKI | VVDGSGQCHS | 
    100:
    TDTVKNTLDP | KWNQHYDLYV | GKTDSITISV | WNHKKIHKKQ | GAGFLGCVRL | 
    150:
    LSNAISRLKD | TGYQRLDLCK | LNPSDTDAVR | GQIVVSLQTR | DRIGTGGSVV | 
    200:
    DCRGLLENEG | TVYEDSGPGR | PLSCFMEEPA | PYTDSTGAAA | GGGNCRFVES | 
    250:
    PSQDQRLQAQ | RLRNPDVRGS | LQTPQNRPHG | HQSPELPEGY | EQRTTVQGQV | 
    300:
    YFLHTQTGVS | TWHDPRIPSP | SGTIPGGDAA | FLYEFLLQGH | TSEPRDLNSV | 
    350:
    NCDELGPLPP | GWEVRSTVSG | RIYFVDHNNR | TTQFTDPRLH | HIMNHQCQLK | 
    400:
    EPSQPLPLPS | EGSLEDEELP | AQRYERDLVQ | KLKVLRHELS | LQQPQAGHCR | 
    450:
    IEVSREEIFE | ESYRQIMKMR | PKDLKKRLMV | KFRGEEGLDY | GGVAREWLYL | 
    500:
    LCHEMLNPYY | GLFQYSTDNI | YMLQINPDSS | INPDHLSYFH | FVGRIMGLAV | 
    550:
    FHGHYINGGF | TVPFYKQLLG | KPIQLSDLES | VDPELHKSLV | WILENDITPV | 
    600:
    LDHTFCVEHN | AFGRILQHEL | KPNGRNVPVT | EENKKEYVRL | YVNWRFMRGI | 
    650:
    EAQFLALQKG | FNELIPQHLL | KPFDQKELEL | IIGGLDKIDL | NDWKSNTRLK | 
    700:
    HCVADSNIVR | WFWQAVETFD | EERRARLLQF | VTGSTRVPLQ | GFKALQGSTG | 
    750:
    AAGPRLFTIH | LIDANTDNLP | KAHTCFNRID | IPPYESYEKL | YEKLLTAVEE | 
    757:
    TCGFAVE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    UniGene:
    String:
    Pfam:
    SMR:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human hSMURF1
    ELISA Kit for Human hSMURF1
    CLIA Kit for Human hSMURF1
    CLIA Kit for Human hSMURF1
    Polyclonal Antibody for Human hSMURF1
    Polyclonal Antibody for Human hSMURF1
    Monoclonal Antibody for Human hSMURF1
    Monoclonal Antibody for Human hSMURF1
    Protein for Human hSMURF1
    Protein for Human hSMURF1

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    Precision
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    Linearity
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    References
    1. 1.
      "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T. , Kikuno R. , Nakayama M. , Hirosawa M. , Ohara O.
      DNA Res.7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG)
      tissue: Brain.
    2. 2.
      "Smurf1-beta, an alternatively spliced variant of Smad-ubiquitin E3 ligase Smurf1."
      Liang M. , Lin X. , Feng X.-H.
      Submitted (2002-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "The DNA sequence of human chromosome 7."
      Hillier L.W. , Fulton R.S. , Fulton L.A. , Graves T.A. , Pepin K.H. , Wagner-McPherson C. , Layman D. , Maas J. , Jaeger S. , Walker R. , Wylie K. , Sekhon M. , Becker M.C. , O'Laughlin M.D. , Schaller M.E. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , more...
      Nature424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS LONG AND SHORT)
      tissue: Brain.
      tissue: Testis.
    6. 7.
      "A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation."
      Zhu H. , Kavsak P. , Abdollah S. , Wrana J.L. , Thomsen G.H.
      Nature400:687-693(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-731 (ISOFORM SHORT);FUNCTION
    7. 8.
      "Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF-beta receptor for degradation."
      Kavsak P. , Rasmussen R.K. , Causing C.G. , Bonni S. , Zhu H. , Thomsen G.H. , Wrana J.L.
      Mol. Cell6:1365-1375(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SMAD7 AND TGFBR1
    8. 9.
      "Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation."
      Li S. , Lu K. , Wang J. , An L. , Yang G. , Chen H. , Cui Y. , Yin X. , Xie P. , Xing G. , He F. , Zhang L.
      Mol. Cell. Biochem.338:11-17(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;MUTAGENESIS OF CYS-725;INTERACTION WITH TRAF4
    9. 10.
      "SCF(FBXL15) regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1."
      Cui Y. , He S. , Xing C. , Lu K. , Wang J. , Xing G. , Meng A. , Jia S. , He F. , Zhang L.
      EMBO J.30:2675-2689(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;UBIQUITINATION AT LYS-381 AND LYS-383;INTERACTION WITH FBXL15;MUTAGENESIS OF LYS-350; LYS-381; LYS-383 AND CYS-725
    10. 11.
      "Pivotal role of the C2 domain of the Smurf1 ubiquitin ligase in substrate selection."
      Lu K. , Li P. , Zhang M. , Xing G. , Li X. , Zhou W. , Bartlam M. , Zhang L. , Rao Z. , He F.
      J. Biol. Chem.286:16861-16870(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.96 ANGSTROMS) OF 13-140;FUNCTION;DOMAIN C2;INTERACTION WITH RHOA;MUTAGENESIS OF LYS-28 AND LYS-85
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