Gene name:
SMURF1 (KIAA1625) ;
Protein name:
E3 ubiquitin-protein ligase SMURF1 (hSMURF1) ;
Alternative:
SMAD-specific E3 ubiquitin-protein ligase 1 ;SMAD ubiquitination regulatory factor 1 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with TRAF4. Interacts (via HECT domain) with FBXL15 (via LRR repeats). Interacts with SMAD7 and TGFBR1; SMAD7 recruits SMURF1 to TGFBR1 and regulates TGF-beta receptor degradation.
Function:
E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Acts by mediating ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MSNPGTRRNG | SSIKIRLTVL | CAKNLAKKDF | FRLPDPFAKI | VVDGSGQCHS |
100:
TDTVKNTLDP | KWNQHYDLYV | GKTDSITISV | WNHKKIHKKQ | GAGFLGCVRL |
150:
LSNAISRLKD | TGYQRLDLCK | LNPSDTDAVR | GQIVVSLQTR | DRIGTGGSVV |
200:
DCRGLLENEG | TVYEDSGPGR | PLSCFMEEPA | PYTDSTGAAA | GGGNCRFVES |
250:
PSQDQRLQAQ | RLRNPDVRGS | LQTPQNRPHG | HQSPELPEGY | EQRTTVQGQV |
300:
YFLHTQTGVS | TWHDPRIPSP | SGTIPGGDAA | FLYEFLLQGH | TSEPRDLNSV |
350:
NCDELGPLPP | GWEVRSTVSG | RIYFVDHNNR | TTQFTDPRLH | HIMNHQCQLK |
400:
EPSQPLPLPS | EGSLEDEELP | AQRYERDLVQ | KLKVLRHELS | LQQPQAGHCR |
450:
IEVSREEIFE | ESYRQIMKMR | PKDLKKRLMV | KFRGEEGLDY | GGVAREWLYL |
500:
LCHEMLNPYY | GLFQYSTDNI | YMLQINPDSS | INPDHLSYFH | FVGRIMGLAV |
550:
FHGHYINGGF | TVPFYKQLLG | KPIQLSDLES | VDPELHKSLV | WILENDITPV |
600:
LDHTFCVEHN | AFGRILQHEL | KPNGRNVPVT | EENKKEYVRL | YVNWRFMRGI |
650:
EAQFLALQKG | FNELIPQHLL | KPFDQKELEL | IIGGLDKIDL | NDWKSNTRLK |
700:
HCVADSNIVR | WFWQAVETFD | EERRARLLQF | VTGSTRVPLQ | GFKALQGSTG |
750:
AAGPRLFTIH | LIDANTDNLP | KAHTCFNRID | IPPYESYEKL | YEKLLTAVEE |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
ELISA Kit for Human hSMURF1
ELISA Kit for Human hSMURF1
CLIA Kit for Human hSMURF1
CLIA Kit for Human hSMURF1
Polyclonal Antibody for Human hSMURF1
Polyclonal Antibody for Human hSMURF1
Monoclonal Antibody for Human hSMURF1
Monoclonal Antibody for Human hSMURF1
Protein for Human hSMURF1
Protein for Human hSMURF1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG)
tissue :
Brain .
2.
"Smurf1-beta, an alternatively spliced variant of Smad-ubiquitin E3 ligase Smurf1."
Liang M.
,
Lin X.
,
Feng X.-H.
Submitted (2002-01) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
3.
"The DNA sequence of human chromosome 7."
Hillier L.W.
,
Fulton R.S.
,
Fulton L.A.
,
Graves T.A.
,
Pepin K.H.
,
Wagner-McPherson C.
,
Layman D.
,
Maas J.
,
Jaeger S.
,
Walker R.
,
Wylie K.
,
Sekhon M.
,
Becker M.C.
,
O'Laughlin M.D.
,
Schaller M.E.
,
Fewell G.A.
,
Delehaunty K.D.
,
Miner T.L.
,
Nash W.E.
,
Cordes M.
,
Du H.
,
Sun H.
,
Edwards J.
,
Bradshaw-Cordum H.
,
Ali J.
,
Andrews S.
,
Isak A.
,
Vanbrunt A.
,
Nguyen C.
,
Du F.
,
Lamar B.
,
Courtney L.
,
Kalicki J.
,
Ozersky P.
,
Bielicki L.
,
Scott K.
,
Holmes A.
,
Harkins R.
,
Harris A.
,
Strong C.M.
,
Hou S.
,
Tomlinson C.
,
Dauphin-Kohlberg S.
,
Kozlowicz-Reilly A.
,
Leonard S.
,
Rohlfing T.
,
Rock S.M.
,
Tin-Wollam A.-M.
,
Abbott A.
,
Minx P.
,
Maupin R.
,
Strowmatt C.
,
Latreille P.
,
Miller N.
,
Johnson D.
,
Murray J.
,
Woessner J.P.
,
Wendl M.C.
,
Yang S.-P.
,
Schultz B.R.
,
Wallis J.W.
,
Spieth J.
,
Bieri T.A.
,
Nelson J.O.
,
Berkowicz N.
,
Wohldmann P.E.
,
Cook L.L.
,
Hickenbotham M.T.
,
Eldred J.
,
Williams D.
,
Bedell J.A.
,
Mardis E.R.
,
Clifton S.W.
,
Chissoe S.L.
,
Marra M.A.
,
Raymond C.
,
Haugen E.
,
Gillett W.
,
Zhou Y.
,
James R.
,
Phelps K.
,
Iadanoto S.
,
Bubb K.
,
Simms E.
,
Levy R.
,
Clendenning J.
,
Kaul R.
,
Kent W.J.
,
Furey T.S.
,
Baertsch R.A.
,
Brent M.R.
,
Keibler E.
,
Flicek P.
,
Bork P.
,
Suyama M.
,
Bailey J.A.
,
Portnoy M.E.
,
Torrents D.
,
Chinwalla A.T.
,
Gish W.R.
,
Eddy S.R.
,
McPherson J.D.
,
Olson M.V.
,
Eichler E.E.
,
Green E.D.
,
Waterston R.H.
,
Wilson R.K.
more...
Nature424:157-164(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
Mural R.J.
,
Istrail S.
,
Sutton G.G.
,
Florea L.
,
Halpern A.L.
,
Mobarry C.M.
,
Lippert R.
,
Walenz B.
,
Shatkay H.
,
Dew I.
,
Miller J.R.
,
Flanigan M.J.
,
Edwards N.J.
,
Bolanos R.
,
Fasulo D.
,
Halldorsson B.V.
,
Hannenhalli S.
,
Turner R.
,
Yooseph S.
,
Lu F.
,
Nusskern D.R.
,
Shue B.C.
,
Zheng X.H.
,
Zhong F.
,
Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
"Human chromosome 7: DNA sequence and biology."
Scherer S.W.
,
Cheung J.
,
MacDonald J.R.
,
Osborne L.R.
,
Nakabayashi K.
,
Herbrick J.-A.
,
Carson A.R.
,
Parker-Katiraee L.
,
Skaug J.
,
Khaja R.
,
Zhang J.
,
Hudek A.K.
,
Li M.
,
Haddad M.
,
Duggan G.E.
,
Fernandez B.A.
,
Kanematsu E.
,
Gentles S.
,
Christopoulos C.C.
,
Choufani S.
,
Kwasnicka D.
,
Zheng X.H.
,
Lai Z.
,
Nusskern D.R.
,
Zhang Q.
,
Gu Z.
,
Lu F.
,
Zeesman S.
,
Nowaczyk M.J.
,
Teshima I.
,
Chitayat D.
,
Shuman C.
,
Weksberg R.
,
Zackai E.H.
,
Grebe T.A.
,
Cox S.R.
,
Kirkpatrick S.J.
,
Rahman N.
,
Friedman J.M.
,
Heng H.H.Q.
,
Pelicci P.G.
,
Lo-Coco F.
,
Belloni E.
,
Shaffer L.G.
,
Pober B.
,
Morton C.C.
,
Gusella J.F.
,
Bruns G.A.P.
,
Korf B.R.
,
Quade B.J.
,
Ligon A.H.
,
Ferguson H.
,
Higgins A.W.
,
Leach N.T.
,
Herrick S.R.
,
Lemyre E.
,
Farra C.G.
,
Kim H.-G.
,
Summers A.M.
,
Gripp K.W.
,
Roberts W.
,
Szatmari P.
,
Winsor E.J.T.
,
Grzeschik K.-H.
,
Teebi A.
,
Minassian B.A.
,
Kere J.
,
Armengol L.
,
Pujana M.A.
,
Estivill X.
,
Wilson M.D.
,
Koop B.F.
,
Tosi S.
,
Moore G.E.
,
Boright A.P.
,
Zlotorynski E.
,
Kerem B.
,
Kroisel P.M.
,
Petek E.
,
Oscier D.G.
,
Mould S.J.
,
Doehner H.
,
Doehner K.
,
Rommens J.M.
,
Vincent J.B.
,
Venter J.C.
,
Li P.W.
,
Mural R.J.
,
Adams M.D.
,
Tsui L.-C.
more...
Science300:767-772(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS LONG AND SHORT)
tissue :
Brain .
tissue :
Testis .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 10-731 (ISOFORM SHORT);FUNCTION
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SMAD7 AND TGFBR1
9.
"Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation."
Li S.
,
Lu K.
,
Wang J.
,
An L.
,
Yang G.
,
Chen H.
,
Cui Y.
,
Yin X.
,
Xie P.
,
Xing G.
,
He F.
,
Zhang L.
Mol. Cell. Biochem.338:11-17(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;CATALYTIC ACTIVITY;MUTAGENESIS OF CYS-725;INTERACTION WITH TRAF4
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;UBIQUITINATION AT LYS-381 AND LYS-383;INTERACTION WITH FBXL15;MUTAGENESIS OF LYS-350; LYS-381; LYS-383 AND CYS-725
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.96 ANGSTROMS) OF 13-140;FUNCTION;DOMAIN C2;INTERACTION WITH RHOA;MUTAGENESIS OF LYS-28 AND LYS-85