Protein name:
Sorting nexin-1 ;
Alternative:
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Homodimer. Self-assembles into a complex of approximately 300 kDa. Interacts with HGS. Component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2. Interacts with SNX6.
Function:
May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).
Subcellular Location:
Endosome membrane
Peripheral membrane protein
Cytoplasmic side
Golgi apparatus
trans-Golgi network membrane
Peripheral membrane protein
Cytoplasmic side
Early endosome membrane
Peripheral membrane protein
Cytoplasmic side
Enriched on tubular elements of the early endosome membrane. Binds preferentially to highly curved membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).
Protein Attributes:
50:
MASGGGGCSA | SERLPPPFPG | LEPESEGAVG | GSEPEAGDSD | TEGEDIFTGA |
100:
AAVSKPQSPK | RIASLLPINS | GSKENGIHEE | QDQEPQDLFA | DATVELSLDS |
150:
TQNNQKKVPA | KTLISLPPQE | ATNSSKPQPS | YEELEEEEQE | DQFDLTVGIT |
200:
DPEKIGDGMN | AYVAYKVTTQ | TSLPMFRSKH | FAVKRRFSDF | LGLYEKLSEK |
250:
HSQNGFIVPP | PPEKSLIGMT | KVKVGKEDSS | SAEFLEKRRA | ALERYLQRIV |
300:
NHPTMLQDPD | VREFLEKEEL | PRAVGTQTLS | GAGLLKMFNK | ATDAVSKMTI |
350:
NMNESDIWFE | EKLQEVECEE | QRLRKLHAVV | ETLVNHRKEL | ALNTAQFAKS |
400:
LAMLGSSEDN | TALSRALSQL | AEVEEKIEQL | HQEQANNDFF | LLAELLSDYI |
450:
RLLAIVRAAF | DQRMKTWQRW | QDAQTTLQKK | REAEARLLWA | NKPDKLQQAK |
500:
DEIVEWESRV | TQYERDFERI | STVVRKEVIR | FEKEKSRDFR | NHVIQYLETL |
522:
LHSQQQLAKY | WEAFLPEAKA | IS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Bovine
Rat
Mouse
ELISA Kit for Bovine Sorting nexin-1
ELISA Kit for Bovine Sorting nexin-1
ELISA Kit for Bovine Sorting nexin-1
ELISA Kit for Bovine Sorting nexin-1
CLIA Kit for Bovine Sorting nexin-1
CLIA Kit for Bovine Sorting nexin-1
CLIA Kit for Bovine Sorting nexin-1
CLIA Kit for Bovine Sorting nexin-1
Polyclonal Antibody for Bovine Sorting nexin-1
Polyclonal Antibody for Bovine Sorting nexin-1
Polyclonal Antibody for Bovine Sorting nexin-1
Polyclonal Antibody for Bovine Sorting nexin-1
Monoclonal Antibody for Bovine Sorting nexin-1
Monoclonal Antibody for Bovine Sorting nexin-1
Monoclonal Antibody for Bovine Sorting nexin-1
Monoclonal Antibody for Bovine Sorting nexin-1
Protein for Bovine Sorting nexin-1
Protein for Bovine Sorting nexin-1
Protein for Bovine Sorting nexin-1
Protein for Bovine Sorting nexin-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
Hereford .
tissue :
Heart ventricle .