Siglec1 ELISA Kit for Mouse(Mus musculus) | EIAab.comSiglec1 ELISA Kit for Mouse(Mus musculus)

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Index > Protein center > Siglec1(Gene name) > Mouse

Siglec1 (Gene name),

Sialoadhesin (Protein name ), SN_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Siglec1(Sa;Sn);

Protein name:

Sialoadhesin;

Alternative:

Sialic acid-binding Ig-like lectin 1(Siglec-1);Sheep erythrocyte receptor(SER);

CD:

CD169;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

N/A

Function:

Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells. May play a role in hemopoiesis.

Subcellular Location:

Isoform 3 Secreted

Protein Attributes:

Sequence length:

1695

Sequence:

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1695:

LCLLLGLVAY | HTWRKKSSTK | LNEDENSAEM | ATKKNTIQEE | VVAAL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF08205

SMR:

Q62230

String:

Q62230

KEGG:

mmu:20612

UniGene:

Mm.1374

Uniprot:

Q62230

FOR

ELISA Kit for Mouse Sialoadhesin

CLIA Kit for Mouse Sialoadhesin

Polyclonal Antibody for Mouse Sialoadhesin

Monoclonal Antibody for Mouse Sialoadhesin

Protein for Mouse Sialoadhesin

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Sialoadhesin, a macrophage sialic acid binding receptor for haemopoietic cells with 17 immunoglobulin-like domains."
Crocker P.R. , Mucklow S. , Boukson V. , McWilliam A. , Willis A.C. , Gordon S. , Milon G. , Kelm S. , Bradfield P.
EMBO J.13:4490-4503(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3);PARTIAL PROTEIN SEQUENCE
strain: C57BL/6.
tissue: Macrophage.
2.

"Characterization of the mouse sialoadhesin gene, Sn."
Mucklow S. , Gordon S. , Crocker P.R.
Mamm. Genome8:934-937(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
4.

"Purification and properties of sialoadhesin, a sialic acid-binding receptor of murine tissue macrophages."
Crocker P.R.
EMBO J.10:1661-1669(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
strain: C57BL/6.
tissue: Spleen.
5.

"Sialoadhesin, myelin-associated glycoprotein and CD22 define a new family of sialic acid-dependent adhesion molecules of the immunoglobulin superfamily."
Kelm S. , Pelz A. , Schauer R. , Filbin M.T. , Tang S. , de Bellard M.E. , Schnaar R.L. , Mahoney J.A. , Hartnell A. , Bradfield P. , Crocker P.R.
Curr. Biol.4:965-972(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SIALIC ACID-BINDING
6.

"CD43 functions as a T cell counterreceptor for the macrophage adhesion receptor sialoadhesin (Siglec-1)."
van den Berg T.K. , Nath D. , Ziltener H.J. , Vestweber D. , Fukuda M. , van Die I. , Crocker P.R.
J. Immunol.166:3637-3640(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SPN
7.

"Identification of sialoadhesin as a dominant lymph node counter-receptor for mouse macrophage galactose-type C-type lectin 1."
Kumamoto Y. , Higashi N. , Denda-Nagai K. , Tsuiji M. , Sato K. , Crocker P.R. , Irimura T.
J. Biol. Chem.279:49274-49280(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CLEC10A;TISSUE SPECIFICITY
8.

"Crystal structure of the N-terminal domain of sialoadhesin in complex with 3' sialyllactose at 1.85 A resolution."
May A.P. , Robinson R.C. , Vinson M. , Crocker P.R. , Jones E.Y.
Mol. Cell1:719-728(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 20-138 IN COMPLEX WITH 3'SIALYLLACTOSE
9.

"Molecular analysis of sialoside binding to sialoadhesin by NMR and site-directed mutagenesis."
Crocker P.R. , Vinson M. , Kelm S. , Drickamer K.
Biochem. J.341:355-361(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 20-138;MUTAGENESIS OF TRP-21 AND ARG-116
10.

"Structure-guided design of sialic acid-based Siglec inhibitors and crystallographic analysis in complex with sialoadhesin."
Zaccai N.R. , Maenaka K. , Maenaka T. , Crocker P.R. , Brossmer R. , Kelm S. , Jones E.Y.
Structure11:557-567(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 20-138 IN COMPLEX WITH SIALIC ACID-BASED INHIBITORS
11.

"Complex of sialoadhesin with a glycopeptide ligand."
Bukrinsky J.T. , St Hilaire P.M. , Meldal M. , Crocker P.R. , Henriksen A.
Biochim. Biophys. Acta1702:173-179(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 20-137 IN COMPLEX WITH SIALIC ACID-CONTAINING PEPTIDE;DISULFIDE BOND

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