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Index > Protein center > SOCS1(Gene name) > Human
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  • SOCS1 (Gene name),
  • Suppressor of cytokine signaling 1 (Protein name ),  SOCS1_HUMAN from NCBI database.
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  • General Annotation
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  • Gene name:
    SOCS1(SSI1;TIP3);
    Protein name:
    Suppressor of cytokine signaling 1(SOCS-1);
    Alternative:
    STAT-induced STAT inhibitor 1(SSI-1);JAK-binding protein(JAB);Tec-interacting protein 3(TIP-3);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with multiple activated signaling proteins of the tyrosine kinase signaling pathway including JAK family kinases, TEC, KIT, GRB2 and VAV. Binding to JAKs is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK JH1 domain. Binds the SH3 domain of GRB2 via diproline determinants in the N-terminus, and the N-terminal regulatory domain of VAV (By similarity). Interacts with the Elongin BC complex (TCEB1 and TCEB2). Component of an ECS CBC(SOCS1) E3 ubiquitin-protein ligase complex which contains Elongin BC, CUL5, RBX1 and SOCS1 (By similarity). Interacts (via SH2 domain and SOCS box) with TRIM8 (By similarity). Interacts with AXL, CUL2 and FGFR3.
    Function:
    SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2.
    Subcellular Location:
    Nucleus Cytoplasmic vesicle Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.
    Protein Attributes:
    Sequence length:
    211
    Sequence:
    50:
    MVAHNQVAAD | NAVSTAAEPR | RRPEPSSSSS | SSPAAPARPR | PCPAVPAPAP | 
    100:
    GDTHFRTFRS | HADYRRITRA | SALLDACGFY | WGPLSVHGAH | ERLRAEPVGT | 
    150:
    FLVRDSRQRN | CFFALSVKMA | SGPTSIRVHF | QAGRFHLDGS | RESFDCLFEL | 
    200:
    LEHYVAAPRR | MLGAPLRQRR | VRPLQELCRQ | RIVATVGREN | LARIPLNPVL | 
    211:
    RDYLSSFPFQ | I
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    SMR:
    Pfam:
    UniGene:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human SOCS-1
    Cat.:
    E1416h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human SOCS-1
    Cat.:
    E1416m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human SOCS-1
    Cat.:
    E1416r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Human SOCS-1
    Cat.:
    U1416m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human SOCS-1
    Cat.:
    U1416h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human SOCS-1
    Cat.:
    U1416r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human SOCS-1
    Cat.:
    P1416Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human SOCS-1
    Cat.:
    P1416Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human SOCS-1
    Cat.:
    P1416Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human SOCS-1
    Monoclonal Antibody for Human SOCS-1
    Monoclonal Antibody for Human SOCS-1
    Protein for Human SOCS-1
    Protein for Human SOCS-1
    Protein for Human SOCS-1

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    References
    1. 1.
      "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3."
      Minamoto S. , Ikegame K. , Ueno K. , Narazaki M. , Naka T. , Yamamoto H. , Matsumoto T. , Saito H. , Hosoe S. , Kishimoto T.
      Biochem. Biophys. Res. Commun.237:79-83(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: T-cell lymphoma.
    2. 2.
      "SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase."
      Ohya K. , Kajigaya S. , Yamashita Y. , Miyazato A. , Hatake K. , Miura Y. , Ikeda U. , Shimada K. , Ozawa K. , Mano H.
      J. Biol. Chem.272:27178-27182(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Myeloid leukemia cell.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    4. 4.
      "Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively."
      Yandava C.N. , Pillari A. , Drazen J.M.
      Genomics61:108-111(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      Schlueter G.
      Submitted (1999-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 15-211
      tissue: B-cell.
    7. 7.
      "Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor."
      Dey B.R. , Spence S.L. , Nissley P. , Furlanetto R.W.
      J. Biol. Chem.273:24095-24101(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IGF1R
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE;INTERACTION WITH CUL2
    9. 9.
      "Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation."
      Frantsve J. , Schwaller J. , Sternberg D.W. , Kutok J. , Gilliland D.G.
      Mol. Cell. Biol.21:3547-3557(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE
    10. 10.
      "SOCS proteins: negative regulators of cytokine signaling."
      Krebs D.L. , Hilton D.J.
      Stem Cells19:378-387(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    11. 11.
      "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin."
      Hafizi S. , Alindri F. , Karlsson R. , Dahlbaeck B.
      Biochem. Biophys. Res. Commun.299:793-800(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AXL
    12. 12.
      "Cytokine signaling in the brain: putting a SOCS in it?"
      Wang J. , Campbell I.L.
      J. Neurosci. Res.67:423-427(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    13. 13.
      "Suppressors of cytokine signaling (SOCS) 1 and SOCS3 interact with and modulate fibroblast growth factor receptor signaling."
      Ben-Zvi T. , Yayon A. , Gertler A. , Monsonego-Ornan E.
      J. Cell Sci.119:380-387(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FGFR3;SUBCELLULAR LOCATION
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