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Index > Protein center > SOCS2(Gene name) > Human
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  • SOCS2 (Gene name),
  • Suppressor of cytokine signaling 2 (Protein name ),  SOCS2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    SOCS2(CIS2;SSI2;STATI2);
    Protein name:
    Suppressor of cytokine signaling 2(SOCS-2);
    Alternative:
    STAT-induced STAT inhibitor 2(SSI-2);Cytokine-inducible SH2 protein 2(CIS-2);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with IGF1 receptor, prolactin receptor and growth hormone (GH) receptor. Associates with the Elongin BC complex.
    Function:
    SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    198
    Sequence:
    50:
    MTLRCLEPSG | NGGEGTRSQW | GTAGSAEEPS | PQAARLAKAL | RELGQTGWYW | 
    100:
    GSMTVNEAKE | KLKEAPEGTF | LIRDSSHSDY | LLTISVKTSA | GPTNLRIEYQ | 
    150:
    DGKFRLDSII | CVKSKLKQFD | SVVHLIDYYV | QMCKDKRTGP | EAPRNGTVHL | 
    198:
    YLTKPLYTSA | PSLQHLCRLT | INKCTGAIWG | LPLPTRLKDY | LEEYKFQV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    Pfam:
    KEGG:
    SMR:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human SOCS-2
    Cat.:
    E1415h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human SOCS-2
    Cat.:
    E1415m
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human SOCS-2
    Cat.:
    E1415r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human SOCS-2
    Cat.:
    E1415b
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human SOCS-2
    Cat.:
    E1415p
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human SOCS-2
    Cat.:
    U1415r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human SOCS-2
    Cat.:
    U1415m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human SOCS-2
    Cat.:
    U1415h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human SOCS-2
    Cat.:
    U1415p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human SOCS-2
    Cat.:
    U1415b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human SOCS-2
    Polyclonal Antibody for Human SOCS-2
    Cat.:
    P1415Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human SOCS-2
    Cat.:
    P1415Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human SOCS-2
    Polyclonal Antibody for Human SOCS-2
    Cat.:
    P1415Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human SOCS-2
    Monoclonal Antibody for Human SOCS-2
    Monoclonal Antibody for Human SOCS-2
    Monoclonal Antibody for Human SOCS-2
    Monoclonal Antibody for Human SOCS-2
    Protein for Human SOCS-2
    Protein for Human SOCS-2
    Protein for Human SOCS-2
    Protein for Human SOCS-2
    Protein for Human SOCS-2

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    References
    1. 1.
      "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3."
      Minamoto S. , Ikegame K. , Ueno K. , Narazaki M. , Naka T. , Yamamoto H. , Matsumoto T. , Saito H. , Hosoe S. , Kishimoto T.
      Biochem. Biophys. Res. Commun.237:79-83(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: T-cell lymphoma.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "Cloning of a novel human gene coding human suppressor of cytokine signaling-2 (HsSOCS-2)."
      Tu Q. , Yu L. , Zhang Q.
      Submitted (1997-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    4. 4.
      "Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor."
      Dey B.R. , Spence S.L. , Nissley P. , Furlanetto R.W.
      J. Biol. Chem.273:24095-24101(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Fetal brain.
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
      tissue: Lung.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    8. 8.
      "Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively."
      Yandava C.N. , Pillari A. , Drazen J.M.
      Genomics61:108-111(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 173-198
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    10. 10.
      "Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase."
      Bullock A.N. , Debreczeni J.E. , Edwards A.M. , Sundstrom M. , Knapp S.
      Proc. Natl. Acad. Sci. U.S.A.103:7637-7642(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) IN COMPLEX WITH THE ELONGIN BC COMPLEX
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