SOCS2 ELISA Kit for Human(Homo sapiens) | EIAab.comSOCS2 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > SOCS2(Gene name) > Human

SOCS2 (Gene name),

Suppressor of cytokine signaling 2 (Protein name ), SOCS2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

SOCS2(CIS2;SSI2;STATI2);

Protein name:

Suppressor of cytokine signaling 2(SOCS-2);

Alternative:

STAT-induced STAT inhibitor 2(SSI-2);Cytokine-inducible SH2 protein 2(CIS-2);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with IGF1 receptor, prolactin receptor and growth hormone (GH) receptor. Associates with the Elongin BC complex.

Function:

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

198

Sequence:

50:

100:

150:

198:

YLTKPLYTSA | PSLQHLCRLT | INKCTGAIWG | LPLPTRLKDY | LEEYKFQV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

O14508

UniGene:

Hs.485572

Pfam:

PF00017

KEGG:

hsa:8835

STRING:

9606.ENSP00000339428

SMR:

O14508

MIM:

605117

Uniprot:

O14508

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ELISA Kit for Human SOCS-2

Cat.:

E1415h

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96T

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ELISA Kit for Human SOCS-2

Cat.:

E1415m

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96T

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ELISA Kit for Human SOCS-2

Cat.:

E1415r

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96T

ELISA Kit for Human SOCS-2

Cat.:

E1415b

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96T

ELISA Kit for Human SOCS-2

Cat.:

E1415p

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96T

CLIA Kit for Human SOCS-2

Cat.:

U1415r

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96T

CLIA Kit for Human SOCS-2

Cat.:

U1415m

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MSDS:

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Packing:

96T

CLIA Kit for Human SOCS-2

Cat.:

U1415h

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MSDS:

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Packing:

96T

CLIA Kit for Human SOCS-2

Cat.:

U1415p

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MSDS:

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Packing:

96T

CLIA Kit for Human SOCS-2

Cat.:

U1415b

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96T

Polyclonal Antibody for Human SOCS-2

Cat.:

P1415Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human SOCS-2

Cat.:

P1415Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human SOCS-2

Cat.:

P1415Rb-m

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40ug/0.2ml

Monoclonal Antibody for Human SOCS-2

Protein for Human SOCS-2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3."
Minamoto S. , Ikegame K. , Ueno K. , Narazaki M. , Naka T. , Yamamoto H. , Matsumoto T. , Saito H. , Hosoe S. , Kishimoto T.
Biochem. Biophys. Res. Commun.237:79-83(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: T-cell lymphoma.
2.

"Cloning and characterization of novel CIS family genes."
Masuhara M. , Sakamoto H. , Matsumoto A. , Suzuki R. , Yasukawa H. , Mitsui K. , Wakioka T. , Tanimura S. , Sasaki A. , Misawa H. , Yokouchi M. , Ohtsubo M. , Yoshimura A.
Biochem. Biophys. Res. Commun.239:439-446(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Cloning of a novel human gene coding human suppressor of cytokine signaling-2 (HsSOCS-2)."
Tu Q. , Yu L. , Zhang Q.
Submitted (1997-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
4.

"Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor."
Dey B.R. , Spence S.L. , Nissley P. , Furlanetto R.W.
J. Biol. Chem.273:24095-24101(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Fetal brain.
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
tissue: Lung.
6.

Mural R.J. , Istrail S. , Sutton G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
8.

"Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively."
Yandava C.N. , Pillari A. , Drazen J.M.
Genomics61:108-111(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 173-198
9.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
10.

"Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase."
Bullock A.N. , Debreczeni J.E. , Edwards A.M. , Sundstrom M. , Knapp S.
Proc. Natl. Acad. Sci. U.S.A.103:7637-7642(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) IN COMPLEX WITH THE ELONGIN BC COMPLEX

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