Gene name:
Socs2 (Cis2;Cish2) ;
Protein name:
Suppressor of cytokine signaling 2 (SOCS-2) ;
Alternative:
Cytokine-inducible SH2 protein 2 (CIS-2) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Associates with the Elongin BC complex.
Function:
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular Location:
N/A
Protein Attributes:
50:
MTLRCLEPSG | NGADRTRSQW | GTAGLPEEQS | PEAARLAKAL | RELSQTGWYW |
100:
GSMTVNEAKE | KLKEAPEGTF | LIRDSSHSDY | LLTISVKTSA | GPTNLRIEYQ |
150:
DGKFRLDSII | CVKSKLKQFD | SVVHLIDYYV | QMCKDKRTGP | EAPRNGTVHL |
198:
YLTKPLYTSA | PTLQHFCRLA | INKCTGTIWG | LPLPTRLKDY | LEEYKFQV
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Bovine
Pig
ELISA Kit for Mouse SOCS-2
ELISA Kit for Mouse SOCS-2
ELISA Kit for Mouse SOCS-2
ELISA Kit for Mouse SOCS-2
ELISA Kit for Mouse SOCS-2
CLIA Kit for Mouse SOCS-2
CLIA Kit for Mouse SOCS-2
CLIA Kit for Mouse SOCS-2
CLIA Kit for Mouse SOCS-2
CLIA Kit for Mouse SOCS-2
Polyclonal Antibody for Mouse SOCS-2
Polyclonal Antibody for Mouse SOCS-2
Polyclonal Antibody for Mouse SOCS-2
Polyclonal Antibody for Mouse SOCS-2
Polyclonal Antibody for Mouse SOCS-2
Monoclonal Antibody for Mouse SOCS-2
Monoclonal Antibody for Mouse SOCS-2
Monoclonal Antibody for Mouse SOCS-2
Monoclonal Antibody for Mouse SOCS-2
Monoclonal Antibody for Mouse SOCS-2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"A family of cytokine-inducible inhibitors of signaling."
Starr R.
,
Willson T.A.
,
Viney E.M.
,
Murray L.J.L.
,
Rayner J.R.
,
Jenkins B.J.
,
Gonda T.J.
,
Alexander W.S.
,
Metcalf D.
,
Nicola N.A.
,
Hilton D.J.
Nature387:917-921(1997)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Thymus .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DEVELOPMENTAL STAGE