SOCS3 ELISA Kit for Bovine(Bos taurus) | EIAab.comSOCS3 ELISA Kit for Bovine(Bos taurus)

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SOCS3 (Gene name),

Suppressor of cytokine signaling 3 (Protein name ), SOCS3_BOVIN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

SOCS3;

Protein name:

Suppressor of cytokine signaling 3(SOCS-3);

Alternative:

Organism:

Bovine (Bos taurus).

General Annotation

Sub Unit:

Interacts with multiple activated proteins of the tyrosine kinase signaling pathway including IGF1 receptor, insulin receptor and JAK2. Binding to JAK2 is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK2 JH1 domain. Binds specific activated tyrosine residues of the leptin, EPO, IL12, GSCF and gp130 receptors. Interaction with CSNK1E stabilizes SOCS3 protein. Component of the probable ECS(SOSC3) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and SOCS3. Interacts with CUL5, RNF7, TCEB1 and TCEB2. Interacts with FGFR3.

Function:

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin and leptin receptors. Inhibits JAK2 kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

229

Sequence:

50:

100:

150:

200:

229:

VNGHLDSYEK | VTQLPGPIRE | FLDQYDAPL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9913.ENSBTAP00000011106

UniGene:

Bt.8137

String:

Q9BEG9

Pfam:

PF00017

SMR:

Q9BEG9

KEGG:

bta:282081

Uniprot:

Q9BEG9

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ELISA Kit for Bovine SOCS-3

Cat.:

E1684r

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96T

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ELISA Kit for Bovine SOCS-3

Cat.:

E1684c

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96T

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ELISA Kit for Bovine SOCS-3

Cat.:

E1684m

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ELISA Kit for Bovine SOCS-3

Cat.:

E1684h

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ELISA Kit for Bovine SOCS-3

Cat.:

E1684d

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96T

ELISA Kit for Bovine SOCS-3

Cat.:

E1684b

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96T

CLIA Kit for Bovine SOCS-3

Cat.:

U1684r

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MSDS:

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96T

CLIA Kit for Bovine SOCS-3

Cat.:

U1684b

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96T

CLIA Kit for Bovine SOCS-3

Cat.:

U1684d

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96T

CLIA Kit for Bovine SOCS-3

Cat.:

U1684c

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96T

CLIA Kit for Bovine SOCS-3

Cat.:

U1684h

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96T

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CLIA Kit for Bovine SOCS-3

Cat.:

U1684m

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96T

Polyclonal Antibody for Bovine SOCS-3

Cat.:

P1684Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Bovine SOCS-3

Cat.:

P1684Rb-r

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40ug/0.2ml

Polyclonal Antibody for Bovine SOCS-3

Cat.:

P1684Rb-h

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40ug/0.2ml

Polyclonal Antibody for Bovine SOCS-3

Monoclonal Antibody for Bovine SOCS-3

Protein for Bovine SOCS-3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Cloning of bovine suppressor of cytokine signaling-3."
Hirano A. , Norimine J. , Brown W.C.
Submitted (2001-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]

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