Gene name:
SOCS3 (CIS3;SSI3) ;
Protein name:
Suppressor of cytokine signaling 3 (SOCS-3) ;
Alternative:
STAT-induced STAT inhibitor 3 (SSI-3) ;Cytokine-inducible SH2 protein 3 (CIS-3) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with multiple activated proteins of the tyrosine kinase signaling pathway including IGF1 receptor, insulin receptor and JAK2. Binding to JAK2 is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK2 JH1 domain. Binds specific activated tyrosine residues of the leptin, EPO, IL12, GSCF and gp130 receptors. Interaction with CSNK1E stabilizes SOCS3 protein. Component of the probable ECS(SOCS3) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and SOCS3. Interacts with CUL5, RNF7, TCEB1 and TCEB2. Interacts with CUL2. Interacts with FGFR3.
Function:
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST.
Protein Attributes:
50:
MVTHSKFPAA | GMSRPLDTSL | RLKTFSSKSE | YQLVVNAVRK | LQESGFYWSA |
100:
VTGGEANLLL | SAEPAGTFLI | RDSSDQRHFF | TLSVKTQSGT | KNLRIQCEGG |
150:
SFSLQSDPRS | TQPVPRFDCV | LKLVHHYMPP | PGAPSFPSPP | TEPSSEVPEQ |
200:
PSAQPLPGSP | PRRAYYIYSG | GEKIPLVLSR | PLSSNVATLQ | HLCRKTVNGH |
225:
LDSYEKVTQL | PGPIREFLDQ | YDAPL
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Chicken
Mouse
Human
Dog
Bovine
ELISA Kit for Human SOCS-3
ELISA Kit for Human SOCS-3
ELISA Kit for Human SOCS-3
ELISA Kit for Human SOCS-3
ELISA Kit for Human SOCS-3
ELISA Kit for Human SOCS-3
CLIA Kit for Human SOCS-3
CLIA Kit for Human SOCS-3
CLIA Kit for Human SOCS-3
CLIA Kit for Human SOCS-3
CLIA Kit for Human SOCS-3
CLIA Kit for Human SOCS-3
Polyclonal Antibody for Human SOCS-3
Polyclonal Antibody for Human SOCS-3
Polyclonal Antibody for Human SOCS-3
Polyclonal Antibody for Human SOCS-3
Polyclonal Antibody for Human SOCS-3
Polyclonal Antibody for Human SOCS-3
Monoclonal Antibody for Human SOCS-3
Monoclonal Antibody for Human SOCS-3
Monoclonal Antibody for Human SOCS-3
Monoclonal Antibody for Human SOCS-3
Monoclonal Antibody for Human SOCS-3
Monoclonal Antibody for Human SOCS-3
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];VARIANT TYR-125
tissue :
T-cell lymphoma .
2.
"Cloning and characterization of novel CIS family genes."
Masuhara M.
,
Sakamoto H.
,
Matsumoto A.
,
Suzuki R.
,
Yasukawa H.
,
Mitsui K.
,
Wakioka T.
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Tanimura S.
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Sasaki A.
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Misawa H.
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Yokouchi M.
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Ohtsubo M.
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Yoshimura A.
Biochem. Biophys. Res. Commun.239:439-446(1997)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Skeletal muscle .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Placenta .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH JAK2;MUTAGENESIS OF LEU-22; PHE-25; GLU-30; TYR-31; VAL-34; LEU-41; GLY-45 AND ARG-71
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH EPOR;MUTAGENESIS OF GLY-53; LEU-58; LEU-93 AND ARG-94
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH IL12RB2;MUTAGENESIS OF ARG-71
8.
"Involvement of casein kinase Iepsilon in cytokine-induced granulocytic differentiation."
Okamura A.
,
Iwata N.
,
Nagata A.
,
Tamekane A.
,
Shimoyama M.
,
Gomyo H.
,
Yakushijin K.
,
Urahama N.
,
Hamaguchi M.
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Fukui C.
,
Chihara K.
,
Ito M.
,
Matsui T.
Blood103:2997-3004(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CSNK1E;PROTEIN STABILIZATION
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN AN E3 UBIQUITIN-PROTEIN LIGASE COMPLEX;INTERACTION WITH CUL5; RNF7; TCEB1 AND TCEB2
10.
"Elevated expression and genetic association links the SOCS3 gene to atopic dermatitis."
Ekelund E.
,
Saeaef A.
,
Tengvall-Linder M.
,
Melen E.
,
Link J.
,
Barker J.
,
Reynolds N.J.
,
Meggitt S.J.
,
Kere J.
,
Wahlgren C.-F.
,
Pershagen G.
,
Wickman M.
,
Nordenskjoeld M.
,
Kockum I.
,
Bradley M.
Am. J. Hum. Genet.78:1060-1065(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : POSSIBLE INVOLVEMENT IN ATOPIC DERMATITIS
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH FGFR3