Socs3 ELISA Kit for Mouse(Mus musculus) | EIAab.comSocs3 ELISA Kit for Mouse(Mus musculus)

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Socs3 (Gene name),

Suppressor of cytokine signaling 3 (Protein name ), SOCS3_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Socs3(Cis3;Cish3);

Protein name:

Suppressor of cytokine signaling 3(SOCS-3);

Alternative:

Protein EF-10;Cytokine-inducible SH2 protein 3(CIS-3);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with multiple activated proteins of the tyrosine kinase signaling pathway including IGF1 receptor, insulin receptor and JAK2. Binding to JAK2 is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK2 JH1 domain. Binds specific activated tyrosine residues of the leptin, EPO, IL12, GSCF and gp130 receptors. Interaction with CSNK1E stabilizes SOCS3 protein. Component of the probable ECS(SOCS3) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, elongin BC complex and SOCS3. Interacts with CUL5, RNF7, TCEB1 and TCEB2. Interacts with FGFR3.

Function:

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Seems to recognize IL6ST.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

225

Sequence:

50:

100:

150:

200:

225:

LDSYEKVTQL | PGPIREFLDQ | YDAPL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

mmu:12702

Pfam:

PF00017

STRING:

10090.ENSMUSP00000059129

UniGene:

Mm.3468

String:

O35718

SMR:

O35718

Uniprot:

O35718

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ELISA Kit for Mouse SOCS-3

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E1684r

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ELISA Kit for Mouse SOCS-3

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E1684c

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96T

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ELISA Kit for Mouse SOCS-3

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E1684m

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ELISA Kit for Mouse SOCS-3

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E1684h

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ELISA Kit for Mouse SOCS-3

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E1684d

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ELISA Kit for Mouse SOCS-3

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E1684b

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96T

CLIA Kit for Mouse SOCS-3

Cat.:

U1684r

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96T

CLIA Kit for Mouse SOCS-3

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U1684b

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96T

CLIA Kit for Mouse SOCS-3

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U1684d

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96T

CLIA Kit for Mouse SOCS-3

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U1684c

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96T

CLIA Kit for Mouse SOCS-3

Cat.:

U1684h

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CLIA Kit for Mouse SOCS-3

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U1684m

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Polyclonal Antibody for Mouse SOCS-3

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P1684Rb-m

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40ug/0.2ml

Polyclonal Antibody for Mouse SOCS-3

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P1684Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse SOCS-3

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P1684Rb-h

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Polyclonal Antibody for Mouse SOCS-3

Monoclonal Antibody for Mouse SOCS-3

Protein for Mouse SOCS-3

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"A family of cytokine-inducible inhibitors of signaling."
Starr R. , Willson T.A. , Viney E.M. , Murray L.J.L. , Rayner J.R. , Jenkins B.J. , Gonda T.J. , Alexander W.S. , Metcalf D. , Nicola N.A. , Hilton D.J.
Nature387:917-921(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Lung.
tissue: Thymus.
2.

"Murine SOCS3 gene structure."
Le Provost F. , Henninghausen L.
Submitted (2000-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
strain: NOD.
tissue: Bone marrow.
tissue: Cerebellum.
tissue: Spleen.
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6.
tissue: Brain.
5.

"Autoregulation of pituitary corticotroph SOCS-3 expression: characterization of the murine SOCS-3 promoter."
Auernhammer C.J. , Bousquet C. , Melmed S.
Proc. Natl. Acad. Sci. U.S.A.96:6964-6969(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-30
strain: ICR X Swiss Webster.
6.

"E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblasts."
Fu X. , Kamps M.P.
Mol. Cell. Biol.17:1503-1512(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 221-225
strain: BALB/c.
7.

"Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction."
Nicholson S.E. , Willson T.A. , Farley A. , Starr R. , Zhang J.-G. , Baca M. , Alexander W.S. , Metcalf D. , Hilton D.J. , Nicola N.A.
EMBO J.18:375-385(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN LIF AND IL6 SIGNALING
8.

"SOCS-3 is an insulin-induced negative regulator of insulin signaling."
Emanuelli B. , Peraldi P. , Filloux C. , Sawka-Verhelle D. , Hilton D. , Van Obberghen E.
J. Biol. Chem.275:15985-15991(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN INHIBITION OF INSR KINASE ACTIVITY;INTERACTION WITH INSR
9.

"CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2."
Sasaki A. , Yasukawa H. , Shouda T. , Kitamura T. , Dikic I. , Yoshimura A.
J. Biol. Chem.275:29338-29347(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EPOR AND JAK2;MUTAGENESIS OF LEU-22; PHE-25; GLY-45 AND ARG-71
10.

"Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation."
Seki Y. , Hayashi K. , Matsumoto A. , Seki N. , Tsukada J. , Ransom J. , Naka T. , Kishimoto T. , Yoshimura A. , Kubo M.
Proc. Natl. Acad. Sci. U.S.A.99:13003-13008(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
11.

"SOCS3 is essential in the regulation of fetal liver erythropoiesis."
Marine J.-C. , McKay C. , Wang D. , Topham D.J. , Parganas E. , Nakajima H. , Pendeville H. , Yasukawa H. , Sasaki A. , Yoshimura A. , Ihle J.N.
Cell98:617-627(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ERYTHROPOIESIS
12.

"SOCS3 negatively regulates IL-6 signaling in vivo."
Croker B.A. , Krebs D.L. , Zhang J.-G. , Wormald S. , Willson T.A. , Stanley E.G. , Robb L. , Greenhalgh C.J. , Foerster I. , Clausen B.E. , Nicola N.A. , Metcalf D. , Hilton D.J. , Roberts A.W. , Alexander W.S.
Nat. Immunol.4:540-545(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ROLE IN IL-6 SIGNALING
13.

"SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses."
Seki Y. , Inoue H. , Nagata N. , Hayashi K. , Fukuyama S. , Matsumoto K. , Komine O. , Hamano S. , Himeno K. , Inagaki-Ohara K. , Cacalano N. , O'Garra A. , Oshida T. , Saito H. , Johnston J.A. , Yoshimura A. , Kubo M.
Nat. Med.9:1047-1054(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ROLE IN ALLERGIC RESPONSE;INDUCTION BY IL-4
14.

"BCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling through interaction with Pellino2."
Liu Y. , Dong W. , Chen L. , Xiang R. , Xiao H. , De G. , Wang Z. , Qi Y.
J. Biol. Chem.279:37436-37444(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BCL10
15.

"The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability."
Babon J.J. , McManus E.J. , Yao S. , DeSouza D.P. , Mielke L.A. , Sprigg N.S. , Willson T.A. , Hilton D.J. , Nicola N.A. , Baca M. , Nicholson S.E. , Norton R.S.
Mol. Cell22:205-216(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 22-185
16.

"Structural basis for phosphotyrosine recognition by suppressor of cytokine signaling-3."
Bergamin E. , Wu J. , Hubbard S.R.
Structure14:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 15-185 IN COMPLEX WITH PHOSPHORYLATED IL6ST

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