Socs3 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comSocs3 ELISA Kit for Rat(Rattus norvegicus)

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Socs3 (Gene name),

Suppressor of cytokine signaling 3 (Protein name ), SOCS3_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Socs3(Cish3);

Protein name:

Suppressor of cytokine signaling 3(SOCS-3);

Alternative:

Cytokine-inducible SH2 protein 3;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with multiple activated proteins of the tyrosine kinase signaling pathway including IGF1 receptor, insulin receptor and JAK2. Binding to JAK2 is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK2 JH1 domain. Binds specific activated tyrosine residues of the leptin, EPO, IL12, GSCF and gp130 receptors. Interaction with CSNK1E stabilize SOCS3 protein. Component of the probable ECS(SOCS3) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and SOCS3. Interacts with CUL5, RNF7, TCEB1 and TCEB2. Interacts with FGFR3.

Function:

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

225

Sequence:

50:

100:

150:

200:

225:

LDSYEKVTQL | PGPIREFLDQ | YDAPL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

rno:89829

Pfam:

PF00017

SMR:

O88583

STRING:

10116.ENSRNOP00000003940

UniGene:

Rn.127801

String:

O88583

Uniprot:

O88583

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ELISA Kit for Rat SOCS-3

Cat.:

E1684r

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96T

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ELISA Kit for Rat SOCS-3

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E1684c

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96T

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ELISA Kit for Rat SOCS-3

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E1684m

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ELISA Kit for Rat SOCS-3

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E1684h

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ELISA Kit for Rat SOCS-3

Cat.:

E1684d

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96T

ELISA Kit for Rat SOCS-3

Cat.:

E1684b

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96T

CLIA Kit for Rat SOCS-3

Cat.:

U1684r

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MSDS:

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96T

CLIA Kit for Rat SOCS-3

Cat.:

U1684b

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96T

CLIA Kit for Rat SOCS-3

Cat.:

U1684d

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96T

CLIA Kit for Rat SOCS-3

Cat.:

U1684c

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96T

CLIA Kit for Rat SOCS-3

Cat.:

U1684h

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96T

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CLIA Kit for Rat SOCS-3

Cat.:

U1684m

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Packing:

96T

Polyclonal Antibody for Rat SOCS-3

Cat.:

P1684Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat SOCS-3

Cat.:

P1684Rb-r

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40ug/0.2ml

Polyclonal Antibody for Rat SOCS-3

Cat.:

P1684Rb-h

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40ug/0.2ml

Polyclonal Antibody for Rat SOCS-3

Monoclonal Antibody for Rat SOCS-3

Protein for Rat SOCS-3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Endotoxin-induced inhibition of growth hormone receptor signaling in rat liver in vivo."
Mao Y. , Ling P.R. , Fitzgibbons T.P. , McCowen K.C. , Frick G.P. , Bistrian B.R. , Smith R.J.
Endocrinology140:5505-5515(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: Sprague-Dawley.
tissue: Liver.
2.

le Cam A.
Submitted (1999-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain: Sprague-Dawley.
3.

"Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor."
Eyckerman S. , Broekaert D. , Verhee A. , Vandekerckhove J. , Tavernier J.
FEBS Lett.486:33-37(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LEPTIN

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