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Index > Protein center > Sort1(Gene name) > Rat
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  • Sort1 (Gene name),
  • Sortilin (Protein name ),  SORT_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    Sort1;
    Protein name:
    Sortilin;
    Alternative:
    Neurotensin receptor 3(NTR3);Glycoprotein 110(Gp110);
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Interacts with the cytosolic adapter proteins GGA1 and GGA2. Interacts with numerous ligands including the receptor-associated protein LRPAP1/RAP and GM2A, LPL, NTS, PSAP and SLC2A4. Forms a complex with NGFR which binds specifically to the precursor form of NGFB (proNGFB) (By similarity). Interacts with the precursor form of BDNF (proBDNF).
    Function:
    Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.
    Subcellular Location:
    Membrane Single-pass type I membrane protein Endoplasmic reticulum membrane Single-pass type I membrane protein Endosome membrane Single-pass type I membrane protein Golgi apparatus Golgi stack membrane Single-pass type I membrane protein Lysosome membrane Single-pass type I membrane protein Nucleus membrane Single-pass type I membrane protein Cell membrane Single-pass type I membrane protein Extracellular side Lysosome membrane Single-pass type I membrane protein Localized to membranes of the endosomes, Golgi stack, lysosomes and nucleus. Localization to the plasma membrane in adipocytes is enhanced by insulin (By similarity). Localized to the endoplasmic reticulum and the plasma membrane. Also found in SLC2A4/GLUT4 storage vesicles (GSVs) in adipocytes.
    Protein Attributes:
    Sequence length:
    825
    Sequence:
    50:
    MERPRGAADG | LLRWPLGLLL | LLQLLPPAAV | GQDRLDAPPP | PAPPLLRWAG | 
    100:
    PVGVSWGLRA | AAPGGPVPRA | GRWRRGAPAE | DQDCGRLPDF | IAKLTNNTHQ | 
    150:
    HVFDDLSGSV | SLSWVGDSTG | VILVLTTFQV | PLVIVSFGQS | KLYRSEDYGK | 
    200:
    NFKDITNLIN | NTFIRTEFGM | AIGPENSGKV | ILTAEVSGGS | RGGRVFRSSD | 
    250:
    FAKNFVQTDL | PFHPLTQMMY | SPQNSDYLLA | LSTENGLWVS | KNFGEKWEEI | 
    300:
    HKAVCLAKWG | PNNIIFFTTH | VNGSCKADLG | ALELWRTSDL | GKTFKTIGVK | 
    350:
    IYSFGLGGRF | LFASVMADKD | TTRRIHVSTD | QGDTWSMAQL | PSVGQEQFYS | 
    400:
    ILAANDDMVF | MHVDEPGDTG | FGTIFTSDDR | GIVYSKSLDR | HLYTTTGGET | 
    450:
    DFTNVTSLRG | VYITSTLSED | NSIQSMITFD | QGGRWEHLQK | PENSKCDATA | 
    500:
    KNKNECSLHI | HASYSISQKL | NVPMAPLSEP | NAVGIVIAHG | SVGDAISVMV | 
    550:
    PDVYISDDGG | YSWAKMLEGP | HYYTILDSGG | IIVAIEHSNR | PINVIKFSTD | 
    600:
    EGQCWQSYVF | SQEPVYFTGL | ASEPGARSMN | ISIWGFTESF | LTRQWVSYTI | 
    650:
    DFKDILERNC | EENDYTTWLA | HSTDPGDYKD | GCILGYKEQF | LRLRKSSVCQ | 
    700:
    NGRDYVVAKQ | PSICPCSLED | FLCDFGYFRP | ENASECVEQP | ELKGHELEFC | 
    750:
    LYGKEEHLTT | NGYRKIPGDR | CQGGMNPARE | VKDLKKKCTS | NFLNPKKQNS | 
    800:
    KSSSVPIILA | IVGLMLVTVV | AGVLIVKKYV | CGGRFLVHRY | SVLQQHAEAD | 
    825:
    GVEALDTASH | AKSGYHDDSD | EDLLE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    KEGG:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Sortilin
    Cat.:
    E9893r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Rat Sortilin
    Cat.:
    E9893h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Rat Sortilin
    Cat.:
    E9893m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Sortilin
    Cat.:
    U9893m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Sortilin
    Cat.:
    U9893r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Sortilin
    Cat.:
    U9893h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat Sortilin
    Cat.:
    P9893Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Sortilin
    Cat.:
    P9893Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Sortilin
    Cat.:
    P9893Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat Sortilin
    Monoclonal Antibody for Rat Sortilin
    Monoclonal Antibody for Rat Sortilin
    Protein for Rat Sortilin
    Protein for Rat Sortilin
    Protein for Rat Sortilin

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A. , Weinstock G.M. , Metzker M.L. , Muzny D.M. , Sodergren E.J. , Scherer S. , Scott G. , Steffen D. , Worley K.C. , Burch P.E. , Okwuonu G. , Hines S. , Lewis L. , Deramo C. , Delgado O. , Dugan-Rocha S. , Miner G. , Morgan M. , more...
      Nature428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: Brown Norway.
    2. 2.
      "Sortilin is the major 110-kDa protein in GLUT4 vesicles from adipocytes."
      Morris N.J. , Ross S.A. , Lane W.S. , Moestrup S.K. , Petersen C.M. , Keller S.R. , Lienhard G.E.
      J. Biol. Chem.273:3582-3587(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 89-825;PROTEIN SEQUENCE OF 78-93;PARTIAL PROTEIN SEQUENCE;SUBCELLULAR LOCATION
      strain: Sprague-Dawley.
      tissue: Adipocyte.
    3. 3.
      "Sortilin is a major protein component of Glut4-containing vesicles."
      Lin B.-Z. , Pilch P.F. , Kandror K.V.
      J. Biol. Chem.272:24145-24147(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 121-745;PARTIAL PROTEIN SEQUENCE;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
      strain: Sprague-Dawley.
      tissue: Skeletal muscle.
    4. 4.
      "The prodomain of a secreted hydrophobic mini-protein facilitates its export from the endoplasmic reticulum by hitchhiking on sorting receptors."
      Conticello S.G. , Kowalsman N.D. , Jacobsen C. , Yudkovsky G. , Sato K. , Elazar Z. , Petersen C.M. , Aronheim A. , Fainzilber M.
      J. Biol. Chem.278:26311-26314(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    5. 5.
      "Distribution of NTS3 receptor/sortilin mRNA and protein in the rat central nervous system."
      Sarret P. , Krzywkowski P. , Segal L. , Nielsen M.S. , Petersen C.M. , Mazella J. , Stroh T. , Beaudet A.
      J. Comp. Neurol.461:483-505(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    6. 6.
      "Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway."
      Chen Z.-Y. , Ieraci A. , Teng H. , Dall H. , Meng C.-X. , Herrera D.G. , Nykjaer A. , Hempstead B.L. , Lee F.S.
      J. Neurosci.25:6156-6166(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BDNF
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