Protein name:
Sortilin ;
Alternative:
Neurotensin receptor 3 (NTR3) ;Glycoprotein 110 (Gp110) ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Interacts with the cytosolic adapter proteins GGA1 and GGA2. Interacts with numerous ligands including the receptor-associated protein LRPAP1/RAP and GM2A, LPL, NTS, PSAP and SLC2A4. Forms a complex with NGFR which binds specifically to the precursor form of NGFB (proNGFB) (By similarity). Interacts with the precursor form of BDNF (proBDNF).
Function:
Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Endoplasmic reticulum membrane
Single-pass type I membrane protein
Endosome membrane
Single-pass type I membrane protein
Golgi apparatus
Golgi stack membrane
Single-pass type I membrane protein
Lysosome membrane
Single-pass type I membrane protein
Nucleus membrane
Single-pass type I membrane protein
Cell membrane
Single-pass type I membrane protein
Extracellular side
Lysosome membrane
Single-pass type I membrane protein
Localized to membranes of the endosomes, Golgi stack, lysosomes and nucleus. Localization to the plasma membrane in adipocytes is enhanced by insulin (By similarity). Localized to the endoplasmic reticulum and the plasma membrane. Also found in SLC2A4/GLUT4 storage vesicles (GSVs) in adipocytes.
Protein Attributes:
50:
MERPRGAADG | LLRWPLGLLL | LLQLLPPAAV | GQDRLDAPPP | PAPPLLRWAG |
100:
PVGVSWGLRA | AAPGGPVPRA | GRWRRGAPAE | DQDCGRLPDF | IAKLTNNTHQ |
150:
HVFDDLSGSV | SLSWVGDSTG | VILVLTTFQV | PLVIVSFGQS | KLYRSEDYGK |
200:
NFKDITNLIN | NTFIRTEFGM | AIGPENSGKV | ILTAEVSGGS | RGGRVFRSSD |
250:
FAKNFVQTDL | PFHPLTQMMY | SPQNSDYLLA | LSTENGLWVS | KNFGEKWEEI |
300:
HKAVCLAKWG | PNNIIFFTTH | VNGSCKADLG | ALELWRTSDL | GKTFKTIGVK |
350:
IYSFGLGGRF | LFASVMADKD | TTRRIHVSTD | QGDTWSMAQL | PSVGQEQFYS |
400:
ILAANDDMVF | MHVDEPGDTG | FGTIFTSDDR | GIVYSKSLDR | HLYTTTGGET |
450:
DFTNVTSLRG | VYITSTLSED | NSIQSMITFD | QGGRWEHLQK | PENSKCDATA |
500:
KNKNECSLHI | HASYSISQKL | NVPMAPLSEP | NAVGIVIAHG | SVGDAISVMV |
550:
PDVYISDDGG | YSWAKMLEGP | HYYTILDSGG | IIVAIEHSNR | PINVIKFSTD |
600:
EGQCWQSYVF | SQEPVYFTGL | ASEPGARSMN | ISIWGFTESF | LTRQWVSYTI |
650:
DFKDILERNC | EENDYTTWLA | HSTDPGDYKD | GCILGYKEQF | LRLRKSSVCQ |
700:
NGRDYVVAKQ | PSICPCSLED | FLCDFGYFRP | ENASECVEQP | ELKGHELEFC |
750:
LYGKEEHLTT | NGYRKIPGDR | CQGGMNPARE | VKDLKKKCTS | NFLNPKKQNS |
800:
KSSSVPIILA | IVGLMLVTVV | AGVLIVKKYV | CGGRFLVHRY | SVLQQHAEAD |
825:
GVEALDTASH | AKSGYHDDSD | EDLLE
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
ELISA Kit for Rat Sortilin
ELISA Kit for Rat Sortilin
ELISA Kit for Rat Sortilin
CLIA Kit for Rat Sortilin
CLIA Kit for Rat Sortilin
CLIA Kit for Rat Sortilin
Polyclonal Antibody for Rat Sortilin
Polyclonal Antibody for Rat Sortilin
Polyclonal Antibody for Rat Sortilin
Monoclonal Antibody for Rat Sortilin
Monoclonal Antibody for Rat Sortilin
Monoclonal Antibody for Rat Sortilin
R&D Technical Data
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Precision
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Recovery
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Linearity
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more...
Nature428:493-521(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
Brown Norway .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 89-825;PROTEIN SEQUENCE OF 78-93;PARTIAL PROTEIN SEQUENCE;SUBCELLULAR LOCATION
strain :
Sprague-Dawley .
tissue :
Adipocyte .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 121-745;PARTIAL PROTEIN SEQUENCE;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
strain :
Sprague-Dawley .
tissue :
Skeletal muscle .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;TISSUE SPECIFICITY
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH BDNF