Gene name:
SOST (UNQ2976/PRO7455/PRO7476) ;
Protein name:
Sclerostin ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with LRP5 (via the first two YWTD-EGF repeat domains); the interaction inhibits Wnt-mediated signaling.
Function:
Negative regulator of bone growth.
Subcellular Location:
Secreted
Protein Attributes:
50:
MQLPLALCLV | CLLVHTAFRV | VEGQGWQAFK | NDATEIIPEL | GEYPEPPPEL |
100:
ENNKTMNRAE | NGGRPPHHPF | ETKDVSEYSC | RELHFTRYVT | DGPCRSAKPV |
150:
TELVCSGQCG | PARLLPNAIG | RGKWWRPSGP | DFRCIPDRYR | AQRVQLLCPG |
200:
GEAPRARKVR | LVASCKCKRL | TRFHNQSELK | DFGTEAARPQ | KGRKPRPRAR |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Mouse
Human
Bovine
ELISA Kit for Human Sclerostin
ELISA Kit for Human Sclerostin
ELISA Kit for Human Sclerostin
ELISA Kit for Human Sclerostin
CLIA Kit for Human Sclerostin
CLIA Kit for Human Sclerostin
CLIA Kit for Human Sclerostin
CLIA Kit for Human Sclerostin
Polyclonal Antibody for Human Sclerostin
Polyclonal Antibody for Human Sclerostin
Polyclonal Antibody for Human Sclerostin
Polyclonal Antibody for Human Sclerostin
Monoclonal Antibody for Human Sclerostin
Monoclonal Antibody for Human Sclerostin
Monoclonal Antibody for Human Sclerostin
Monoclonal Antibody for Human Sclerostin
Protein for Human Sclerostin
Protein for Human Sclerostin
Protein for Human Sclerostin
Protein for Human Sclerostin
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[1].
M Korkosz, J Gąsowski, P Leszczyński, et al.
[2].
M Korkosz, J Gasowski, P Leszczynski
References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INVOLVEMENT IN SOST1
2.
"Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein."
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Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1);INVOLVEMENT IN SOST1
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
4.
"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
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Nature440:1045-1049(2006)
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PubMed ]
[
Europe PMC ]
[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 24-38
7.
"Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease."
Balemans W.
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Patel N.
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Ebeling M.
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Van Hul E.
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Wuyts W.
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Lacza C.
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Europe PMC ]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN VBCH
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH LRP5 AND LRP6
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY;SUBCELLULAR LOCATION
10.
"Identification of signal peptide domain SOST mutations in autosomal dominant craniodiaphyseal dysplasia."
Kim S.J.
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Bieganski T.
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Sohn Y.B.
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Hum. Genet.129:497-502(2011)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN CDD;VARIANTS CDD MET-21 AND LEU-21;CHARACTERIZATION OF VARIANTS CDD MET-21 AND LEU-21
11.
"Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function."
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Hu S.
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Kramer I.
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Morvan F.
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH LRP4; LRP5 AND LRP6
12.
"Characterization of the structural features and interactions of sclerostin: molecular insight into a key regulator of Wnt-mediated bone formation."
Veverka V.
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Europe PMC ]
[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 25-213;HEPARIN-BINDING;DISULFIDE BONDS
13.
"First missense mutation in the SOST gene causing sclerosteosis by loss of sclerostin function."
Piters E.
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Hum. Mutat.31:E1526-E1543(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT SOST1 ARG-167;CHARACTERIZATION OF VARIANT SOST1 ARG-167