"Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)."
Balemans W. , Ebeling M. , Patel N. , van Hul E. , Olson P. , Dioszegi M. , Lacza C. , Wuyts W. , van den Ende J. , Willems P. , Paes-Alves A.F. , Hill S. , Bueno M. , Ramos F.J. , Tacconi P. , Dikkers F.G. , Stratakis C. , Lindpaintner K. , Vickery B. , Foernzler D. , Van Hul W. more...
Hum. Mol. Genet.10:537-543(2001) [PubMed] [Europe PMC] [Abstract]

"Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein."
Brunkow M.E. , Gardner J.C. , Van Ness J. , Paeper B.W. , Kovacevich B.R. , Proll S. , Skonier J.E. , Zhao L. , Sabo P.J. , Fu Y.H. , Alisch R.S. , Gillett L. , Colbert T. , Tacconi P. , Galas D. , Hamersma H. , Beighton P. , Mulligan J.T.
Am. J. Hum. Genet.68:577-589(2001) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , Heldens S. , Huang A. , Kim H.S. , Klimowski L. , Jin Y. , Johnson S. , Lee J. , Lewis L. , Liao D. , Mark M.R. , Robbie E. , Sanchez C. , Schoenfeld J. , Seshagiri S. , Simmons L. , Singh J. , Smith V. , Stinson J. , Vagts A. , Vandlen R.L. , Watanabe C. , Wieand D. , Woods K. , Xie M.-H. , Yansura D.G. , Yi S. , Yu G. , Yuan J. , Zhang M. , Zhang Z. , Goddard A.D. , Wood W.I. , Godowski P.J. , Gray A.M. more...
Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C. , Garber M. , Adams D.J. , Sharpe T. , Harrow J. , Lupski J.R. , Nicholson C. , Searle S.M. , Wilming L. , Young S.K. , Abouelleil A. , Allen N.R. , Bi W. , Bloom T. , Borowsky M.L. , Bugalter B.E. , Butler J. , Chang J.L. , Chen C.-K. , Cook A. , Corum B. , Cuomo C.A. , de Jong P.J. , DeCaprio D. , Dewar K. , FitzGerald M. , Gilbert J. , Gibson R. , Gnerre S. , Goldstein S. , Grafham D.V. , Grocock R. , Hafez N. , Hagopian D.S. , Hart E. , Norman C.H. , Humphray S. , Jaffe D.B. , Jones M. , Kamal M. , Khodiyar V.K. , LaButti K. , Laird G. , Lehoczky J. , Liu X. , Lokyitsang T. , Loveland J. , Lui A. , Macdonald P. , Major J.E. , Matthews L. , Mauceli E. , McCarroll S.A. , Mihalev A.H. , Mudge J. , Nguyen C. , Nicol R. , O'Leary S.B. , Osoegawa K. , Schwartz D.C. , Shaw-Smith C. , Stankiewicz P. , Steward C. , Swarbreck D. , Venkataraman V. , Whittaker C.A. , Yang X. , Zimmer A.R. , Bradley A. , Hubbard T. , Birren B.W. , Rogers J. , Lander E.S. , Nusbaum C. more...
Nature440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z. , Henzel W.J.
Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease."
Balemans W. , Patel N. , Ebeling M. , Van Hul E. , Wuyts W. , Lacza C. , Dioszegi M. , Dikkers F.G. , Hildering P. , Willems P.J. , Verheij J.B. , Lindpaintner K. , Vickery B. , Foernzler D. , Van Hul W.
J. Med. Genet.39:91-97(2002) [PubMed] [Europe PMC] [Abstract]

"SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor."
Semenov M. , Tamai K. , He X.
J. Biol. Chem.280:26770-26775(2005) [PubMed] [Europe PMC] [Abstract]

"Proteomics characterization of extracellular space components in the human aorta."
Didangelos A. , Yin X. , Mandal K. , Baumert M. , Jahangiri M. , Mayr M.
Mol. Cell. Proteomics9:2048-2062(2010) [PubMed] [Europe PMC] [Abstract]

"Identification of signal peptide domain SOST mutations in autosomal dominant craniodiaphyseal dysplasia."
Kim S.J. , Bieganski T. , Sohn Y.B. , Kozlowski K. , Semenov M. , Okamoto N. , Kim C.H. , Ko A.R. , Ahn G.H. , Choi Y.L. , Park S.W. , Ki C.S. , Kim O.H. , Nishimura G. , Unger S. , Superti-Furga A. , Jin D.K.
Hum. Genet.129:497-502(2011) [PubMed] [Europe PMC] [Abstract]

"Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function."
Leupin O. , Piters E. , Halleux C. , Hu S. , Kramer I. , Morvan F. , Bouwmeester T. , Schirle M. , Bueno-Lozano M. , Fuentes F.J. , Itin P.H. , Boudin E. , de Freitas F. , Jennes K. , Brannetti B. , Charara N. , Ebersbach H. , Geisse S. , Lu C.X. , Bauer A. , Van Hul W. , Kneissel M. more...
J. Biol. Chem.286:19489-19500(2011) [PubMed] [Europe PMC] [Abstract]

"Characterization of the structural features and interactions of sclerostin: molecular insight into a key regulator of Wnt-mediated bone formation."
Veverka V. , Henry A.J. , Slocombe P.M. , Ventom A. , Mulloy B. , Muskett F.W. , Muzylak M. , Greenslade K. , Moore A. , Zhang L. , Gong J. , Qian X. , Paszty C. , Taylor R.J. , Robinson M.K. , Carr M.D.
J. Biol. Chem.284:10890-10900(2009) [PubMed] [Europe PMC] [Abstract]

"First missense mutation in the SOST gene causing sclerosteosis by loss of sclerostin function."
Piters E. , Culha C. , Moester M. , Van Bezooijen R. , Adriaensen D. , Mueller T. , Weidauer S. , Jennes K. , de Freitas F. , Loewik C. , Timmermans J.-P. , Van Hul W. , Papapoulos S.
Hum. Mutat.31:E1526-E1543(2010) [PubMed] [Europe PMC] [Abstract]