Gene name:
SERPINA3-1(SERPINA3A);
Protein name:
Serpin A3-1;
Alternative:
Muscle endopin-1A(mEndopin-1A);Endopin-1A;
Organism:
Bovine (Bos taurus).
General Annotation
Function:
Potent inhibitor of the serine proteases elastase and trypsin. Moderately inhibits the serine proteases plasmin and chymotrypsin, and the thiol protease proenkephalin-processing enzyme. Does not inhibit the serine proteases cathepsin G, furin, kallikrein, thrombin, tissue plasminogen activator and urokinase, or the cysteine proteases cathepsin B, cathepsin L and papain.
Subcellular Location:
Cytoplasmic vesicle
secretory vesicle
chromaffin granule
Secreted
In longissimus muscle myocytes highest levels are found between the plasma membrane and the myofibrils and lower levels are found within the myofibrils. Localised to the chromaffin granules of the adrenal medulla and secreted in response to nicotine or KCL depolarization.
Protein Attributes:
50:
MRAERTSFLL | ALGLLVAGIR | SVHCLPENVV | VKDQHRRVDG | HTLASSNTDF |
100:
AFSLYKQLAL | KNPNKNVILS | PLSVSIALAF | LSLGARGSTL | TEILEGLKFN |
150:
LTEIQEKEIH | HSFQHLLQAL | NQPSNQLQLS | VGNAMFVQEE | LKLLDKFIED |
200:
AQVLYSSEAF | PTNFRDSEAA | RSLINDYVKN | KTQGKIEELF | KYLSPRTELV |
250:
LVNYIYFKAQ | WKTPFDPKHT | EQAEFHVSDN | KTVEVPMMTL | DLETPYFRDE |
300:
ELGCTLVELT | YTSNDSALFI | LPDEGKMRDL | EAKLTPETLT | RWRNSLQPRR |
350:
IHELYLPKFS | IKSNYELNDI | LSQLGIRKIF | ANADLSGITG | TADLVVSQVV |
400:
HGAALDVDEE | GTEGAAATGI | SMERTILRII | VRVNRPFLIA | IVLKDTQSII |

Vaild Sequence:
Related Databases
Uniprot: