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Index > Protein center > SERPINA3-1(Gene name) > Bovine
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  • SERPINA3-1 (Gene name),
  • Serpin A3-1 (Protein name ),  SPA31_BOVIN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    SERPINA3-1(SERPINA3A);
    Protein name:
    Serpin A3-1;
    Alternative:
    Muscle endopin-1A(mEndopin-1A);Endopin-1A;
    Organism:
    Bovine (Bos taurus). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    Potent inhibitor of the serine proteases elastase and trypsin. Moderately inhibits the serine proteases plasmin and chymotrypsin, and the thiol protease proenkephalin-processing enzyme. Does not inhibit the serine proteases cathepsin G, furin, kallikrein, thrombin, tissue plasminogen activator and urokinase, or the cysteine proteases cathepsin B, cathepsin L and papain.
    Subcellular Location:
    Cytoplasmic vesicle secretory vesicle chromaffin granule Secreted In longissimus muscle myocytes highest levels are found between the plasma membrane and the myofibrils and lower levels are found within the myofibrils. Localised to the chromaffin granules of the adrenal medulla and secreted in response to nicotine or KCL depolarization.
    Protein Attributes:
    Sequence length:
    411
    Sequence:
    50:
    MRAERTSFLL | ALGLLVAGIR | SVHCLPENVV | VKDQHRRVDG | HTLASSNTDF | 
    100:
    AFSLYKQLAL | KNPNKNVILS | PLSVSIALAF | LSLGARGSTL | TEILEGLKFN | 
    150:
    LTEIQEKEIH | HSFQHLLQAL | NQPSNQLQLS | VGNAMFVQEE | LKLLDKFIED | 
    200:
    AQVLYSSEAF | PTNFRDSEAA | RSLINDYVKN | KTQGKIEELF | KYLSPRTELV | 
    250:
    LVNYIYFKAQ | WKTPFDPKHT | EQAEFHVSDN | KTVEVPMMTL | DLETPYFRDE | 
    300:
    ELGCTLVELT | YTSNDSALFI | LPDEGKMRDL | EAKLTPETLT | RWRNSLQPRR | 
    350:
    IHELYLPKFS | IKSNYELNDI | LSQLGIRKIF | ANADLSGITG | TADLVVSQVV | 
    400:
    HGAALDVDEE | GTEGAAATGI | SMERTILRII | VRVNRPFLIA | IVLKDTQSII | 
    411:
    FLGKVTNPSE | A
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Bovine Serpin A3-1
    CLIA Kit for Bovine Serpin A3-1
    Polyclonal Antibody for Bovine Serpin A3-1
    Monoclonal Antibody for Bovine Serpin A3-1
    Protein for Bovine Serpin A3-1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular cloning of endopin 1, a novel serpin localized to neurosecretory vesicles of chromaffin cells. Inhibition of basic residue-cleaving proteases by endopin 1."
      Hwang S.-R. , Steineckert B. , Yasothornsrikul S. , Sei C.A. , Toneff T. , Rattan J. , Hook V.Y.H.
      J. Biol. Chem.274:34164-34173(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;GLYCOSYLATION
      tissue: Adrenal medulla.
    2. 2.
      Hwang S.-R. , Steineckert B. , Yasothornsrikul S. , Sei C.A. , Toneff T. , Rattan J. , Kang Y.-H. , Hook V.Y.H.
      Submitted (2003-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 113-152
      tissue: Adrenal medulla.
    3. 3.
      "Purification of the skeletal muscle protein endopin 1B and characterization of the genes encoding endopin 1A and 1B isoforms."
      Herrera-Mendez C.H. , Bremaud L. , Coulis G. , Pelissier P. , Sentandreu M.A. , Aubry L. , Delourme D. , Chambon C. , Maftah A. , Leveziel H. , Ouali A.
      FEBS Lett.580:3477-3484(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];PROTEIN SEQUENCE OF 25-38 AND 313-327;SUBUNIT
      tissue: Muscle.
    4. 4.
      NIH - Mammalian Gene Collection (MGC) project
      Submitted (2006-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: Hereford.
      tissue: Testis.
    5. 5.
      "Muscle endopin 1, a muscle intracellular serpin inhibiting strongly elastase: purification, characterization, cellular localization and tissue distribution."
      Tassy C. , Herrera-Mendez C.H. , Sentandreu M.A. , Aubry L. , Bremaud L. , Pelissier P. , Delourme D. , Brillard M. , Gauthier F. , Leveziel H. , Ouali A.
      Biochem. J.388:273-280(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 25-38 AND 313-327;FUNCTION;BIOPHYSICOCHEMICAL PROPERTIES;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
      tissue: Diaphragm.
    6. 6.
      "An original SERPINA3 gene cluster: elucidation of genomic organization and gene expression in the Bos taurus 21q24 region."
      Pelissier P. , Delourme D. , Germot A. , Blanchet X. , Becila S. , Maftah A. , Leveziel H. , Ouali A. , Bremaud L.
      BMC Genomics9:151-151(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NOMENCLATURE
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