SERPINB3 ELISA Kit for Human(Homo sapiens) | EIAab.comSERPINB3 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > SERPINB3(Gene name) > Human

SERPINB3 (Gene name),

Serpin B3 (Protein name ), SPB3_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

SERPINB3(SCCA;SCCA1);

Protein name:

Serpin B3;

Alternative:

Squamous cell carcinoma antigen 1(SCCA-1);Protein T4-A;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

May act as a protease inhibitor to modulate the host immune response against tumor cells.

Subcellular Location:

Cytoplasm Seems to also be secreted in plasma by cancerous cells but at a low level.

Protein Attributes:

Sequence length:

390

Sequence:

50:

100:

150:

200:

250:

300:

350:

390:

GFGSSPTSTN | EEFHCNHPFL | FFIRQNKTNS | ILFYGRFSSP |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

600517

UniGene:

Hs.227948

String:

P29508

Pfam:

PF00079

SMR:

P29508

KEGG:

hsa:6317

Uniprot:

P29508

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ELISA Kit for Human Serpin B3

Cat.:

E1372h

Price:

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Manual:

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MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human Serpin B3

Cat.:

U1372h

Price:

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Manual:

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MSDS:

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Packing:

96T

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Polyclonal Antibody for Human Serpin B3

Cat.:

P1372Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Serpin B3

Protein for Human Serpin B3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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Citations

[1].

"Identification of Novel Biomarkers in Seasonal Allergic Rhinitis by Combining Proteomic, Multivariate and Pathway Analysis"

H Wang, J Gottfries, F Barrenäs, et al.

From:Plos ONE

References

1.

"Squamous cell carcinoma antigen is a new member of the serine protease inhibitors."
Suminami Y. , Kishi F. , Sekiguchi K. , Kato H.
Biochem. Biophys. Res. Commun.181:51-58(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PARTIAL PROTEIN SEQUENCE;VARIANT ALA-357
2.

"A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene."
Schneider S.S. , Schick C. , Fish K.E. , Miller E. , Pena J.C. , Treter S.D. , Hui S.M. , Silverman G.A.
Proc. Natl. Acad. Sci. U.S.A.92:3147-3151(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1)
3.

"Novel forms of SCC antigen transcripts produced by alternative splicing."
Suminami Y. , Kishi F. , Murakami A. , Sakaguchi Y. , Kato H.
Submitted (2000-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANT ALA-357
4.

"Squamous cell carcinoma antigen 1-mediated binding of hepatitis B virus to hepatocytes does not involve the hepatic serpin clearance system."
Moore P.L. , Ong S. , Harrison T.J.
J. Biol. Chem.278:46709-46717(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ALA-351;MUTAGENESIS OF ALA-341; PHE-352 AND 354-SER-SER-355
tissue: Hepatoma.
5.

"SCCA1 mRNA sequence from human hepatocellular carcinoma cell line HepG2, complete cds."
Tong C. , Chenyu X. , Jun Z. , Ningshao X.
Submitted (2003-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Hepatoma.
6.

"Characterization of the new isoform of squamous cell carcinoma antigen-1 (SCCA-PD) detected in hepatocellular carcinoma."
Turato C. , Biasiolo A. , Quarta S. , Beneduce L. , Zuin J. , Fassina G. , Gatta A. , Pontisso P.
Submitted (2008-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT ALA-351
tissue: Liver.
7.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
8.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Trachea.
9.

Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
Submitted (2005-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ALA-357
tissue: Dermoid cancer.
10.

"DNA sequence and analysis of human chromosome 18."
Nusbaum C. , Zody M.C. , Borowsky M.L. , Kamal M. , Kodira C.D. , Taylor T.D. , Whittaker C.A. , Chang J.L. , Cuomo C.A. , Dewar K. , FitzGerald M.G. , Yang X. , Abouelleil A. , Allen N.R. , Anderson S. , Bloom T. , Bugalter B. , Butler J. , more...
Nature437:551-555(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
11.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
12.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Lung.
13.

Bienvenut W.V. , Bensaad K. , Vousden K.H.
Submitted (2008-02) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1-21; 88-94; 112-125; 147-160; 215-260; 266-300; 322-331 AND 378-386;ACETYLATION AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Osteosarcoma.
14.

"Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma."
Pontisso P. , Calabrese F. , Benvegnu L. , Lise M. , Belluco C. , Ruvoletto M.G. , De Falco S. , Marino M. , Valente M. , Nitti D. , Gatta A. , Fassina G.
Br. J. Cancer90:833-837(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 109-390 (ISOFORM 1);VARIANT ALA-351;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
tissue: Liver cancer.
15.

"Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells."
Uemura Y. , Pak S.C. , Luke C. , Cataltepe S. , Tsu C. , Schick C. , Kamachi Y. , Pomeroy S.L. , Perlmutter D.H. , Silverman G.A.
Int. J. Cancer89:368-377(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
16.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.

"Crystal structure of SCCA1 and insight about the interaction with JNK1."
Zheng B. , Matoba Y. , Kumagai T. , Katagiri C. , Hibino T. , Sugiyama M.
Biochem. Biophys. Res. Commun.380:143-147(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 2-390;FUNCTION;INDUCTION;MUTAGENESIS OF PHE-352;INTERACTION WITH MAPK8
18.

"Increased antiprotease activity of the SERPINB3 polymorphic variant SCCA-PD."
Turato C. , Biasiolo A. , Pengo P. , Frecer V. , Quarta S. , Fasolato S. , Ruvoletto M. , Beneduce L. , Zuin J. , Fassina G. , Gatta A. , Pontisso P.
Exp. Biol. Med.236:281-290(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ALA-351

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