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Index > Protein center > SERPINB5(Gene name) > Human
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  • SERPINB5 (Gene name),
  • Serpin B5 (Protein name ),  SPB5_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    SERPINB5(PI5);
    Protein name:
    Serpin B5;
    Alternative:
    Peptidase inhibitor 5(PI-5);Maspin;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with IRF6.
    Function:
    Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
    Subcellular Location:
    Secreted extracellular space
    Protein Attributes:
    Sequence length:
    375
    Sequence:
    50:
    MDALQLANSA | FAVDLFKQLC | EKEPLGNVLF | SPICLSTSLS | LAQVGAKGDT | 
    100:
    ANEIGQVLHF | ENVKDVPFGF | QTVTSDVNKL | SSFYSLKLIK | RLYVDKSLNL | 
    150:
    STEFISSTKR | PYAKELETVD | FKDKLEETKG | QINNSIKDLT | DGHFENILAD | 
    200:
    NSVNDQTKIL | VVNAAYFVGK | WMKKFSESET | KECPFRVNKT | DTKPVQMMNM | 
    250:
    EATFCMGNID | SINCKIIELP | FQNKHLSMFI | LLPKDVEDES | TGLEKIEKQL | 
    300:
    NSESLSQWTN | PSTMANAKVK | LSIPKFKVEK | MIDPKACLEN | LGLKHIFSED | 
    350:
    TSDFSGMSET | KGVALSNVIH | KVCLEITEDG | GDSIEVPGAR | ILQHKDELNA | 
    375:
    DHPFIYIIRH | NKTRNIIFFG | KFCSP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    MIM:
    KEGG:
    SMR:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Serpin B5
    Cat.:
    E1183h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Serpin B5
    Cat.:
    E1183m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Serpin B5
    Cat.:
    E1183r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Serpin B5
    Cat.:
    U1183r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Serpin B5
    Cat.:
    U1183h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Serpin B5
    Cat.:
    U1183m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Serpin B5
    Cat.:
    P1183Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Serpin B5
    Cat.:
    P1183Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Serpin B5
    Cat.:
    P1183Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Serpin B5
    Monoclonal Antibody for Human Serpin B5
    Monoclonal Antibody for Human Serpin B5
    Protein for Human Serpin B5
    Protein for Human Serpin B5
    Protein for Human Serpin B5

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    Precision
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    Linearity
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    References
    1. 1.
      "Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells."
      Zou Z. , Anisowicz A. , Hendrix M.J.C. , Thor A. , Neveu M. , Sheng S. , Rafidi K. , Seftor E. , Sager R.
      Science263:526-529(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS PRO-176 AND LEU-187
      tissue: Mammary gland.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT PRO-176
      tissue: Esophagus.
    3. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT PRO-176
      tissue: Prostate.
    4. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 245-375 (ISOFORM 1);VARIANT VAL-319
      tissue: Small intestine.
    5. 6.
      "The tumor suppressor maspin does not undergo the stressed to relaxed transition or inhibit trypsin-like serine proteases. Evidence that maspin is not a protease inhibitory serpin."
      Pemberton P.A. , Wong D.T. , Gibson H.L. , Kiefer M.C. , Fitzpatrick P.A. , Sager R. , Barr P.J.
      J. Biol. Chem.270:15832-15837(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 341-360;CHARACTERIZATION
    6. 7.
      "Mammary serine protease inhibitor (Maspin) binds directly to interferon regulatory factor 6: identification of a novel serpin partnership."
      Bailey C.M. , Khalkhali-Ellis Z. , Kondo S. , Margaryan N.V. , Seftor R.E.B. , Wheaton W.W. , Amir S. , Pins M.R. , Schutte B.C. , Hendrix M.J.C.
      J. Biol. Chem.280:34210-34217(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IRF6
    7. 8.
      "The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix."
      Law R.H. , Irving J.A. , Buckle A.M. , Ruzyla K. , Buzza M. , Bashtannyk-Puhalovich T.A. , Beddoe T.C. , Nguyen K. , Worrall D.M. , Bottomley S.P. , Bird P.I. , Rossjohn J. , Whisstock J.C.
      J. Biol. Chem.280:22356-22364(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS)
    8. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] PRO-176;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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