Gene name:
    Serpinb6 (Serpinb6a;Spi3) ;
    
 
    Protein name:
    Serpin B6 ;
    
    Alternative:
    
    Proteinase inhibitor 6 (PI-6) ;Placental thrombin inhibitor ;
    
    
 
    Organism:
        
        
        
        
        
        
    
        Mouse  (Mus musculus).  
    
 
General Annotation
    Sub Unit:
    Forms a complex with the monomeric form of beta-tryptase.
    
 
    Function:
    Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress. May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood.
    
 
    
        
        Subcellular Location:
        
    
     
     
      Cytoplasm 
     
  
    
 
    
    Protein Attributes:
    
    50:
    MDPLQEANGT |  FALNLLKILG |  EDSSKNVFLS |  PMSISSALAM |  VFMGAKGTTA |  
    
 
    100:
    SQMAQALALD |  KCSGNGGGDV |  HQGFQSLLTE |  VNKTGTQYLL |  RTANRLFGDK |  
    
 
    150:
    TCDLLASFKD |  SCLKFYEAEL |  EELDFQGATE |  ESRQHINTWV |  AKKTEDKIKE |  
    
 
    200:
    VLSPGTVNSD |  TSLVLVNAIY |  FKGNWEKQFN |  KEHTREMPFK |  VSKNEEKPVQ |  
    
 
    250:
    MMFKKSTFKM |  TYIGEIFTKI |  LLLPYVSSEL |  NMIIMLPDEH |  VELSTVEKEV |  
    
 
    300:
    TYEKFIEWTR |  LDKMDEEEVE |  VFLPKFKLEE |  NYNMNDALYK |  LGMTDAFGGR |  
    
 
    350:
    ADFSGMSSKQ |  GLFLSKVVHK |  AFVEVNEEGT |  EAAAATAGMM |  TVRCMRFTPR |  
    
 
    378:
    FCADHPFLFF |  IHHVKTNGIL |  FCGRFSSP
    
 
      Vaild Sequence:
    
 
Related Databases
Uniprot:
 
 
    
        
        ELISA Kit
         
        
        CLIA Kit
         
        
        Polyclonal Antibody
         
        
        Monoclonal Antibody
         
        
        Protein
         
        
     
FOR
    
        
        Bovine
         
        
        Human
         
        
        Mouse
         
        
     
    
        ELISA Kit for Mouse Serpin B6
        
     
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Mouse Serpin B6
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Mouse Serpin B6
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Mouse Serpin B6
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Mouse Serpin B6
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Mouse Serpin B6
        
     
    
    
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Mouse Serpin B6
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Mouse Serpin B6
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Mouse Serpin B6
        
     
    
    
    
    
   
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Mouse Serpin B6
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Mouse Serpin B6
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Mouse Serpin B6
        
     
    
    
    
    
    
    
 
    
        Protein for Mouse Serpin B6
        
     
    
    
    
    
    
    
 
    
        Protein for Mouse Serpin B6
        
     
    
    
    
    
    
    
 
    
        Protein for Mouse Serpin B6
        
     
    
    
    
    
    
    
 
 
 
 
 
 
 
 
    R&D Technical Data
    
    
    
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    Precision
    
    
    
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    Recovery
    
    
    
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    Linearity
    
    
    
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    References
    
    
        
            
        
            
                1.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [MRNA] 
                    
                    
                    strain :
                    
BALB/c .  
             
         
            
        
            
                2.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] 
                    
                    
                    tissue :
                    
Mammary tumor .  
             
         
            
        
            
                3.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY 
                    
                    
                 
             
         
            
        
            
                4.
                
                    
                        
                            "A truncating mutation in SERPINB6 is associated with autosomal-recessive nonsyndromic sensorineural hearing loss." 
                        
                        
                            Sirmaci A. 
                        ,
                            
Erbek S. 
                        ,
                            
Price J. 
                        ,
                            
Huang M. 
                        ,
                            
Duman D. 
                        ,
                            
Cengiz F.B. 
                        ,
                            
Bademci G. 
                        ,
                            
Tokgoz-Yilmaz S. 
                        ,
                            
Hismi B. 
                        ,
                            
Ozdag H. 
                        ,
                            
Ozturk B. 
                        ,
                            
Kulaksizoglu S. 
                        ,
                            
Yildirim E. 
                        ,
                            
Kokotas H. 
                        ,
                            
Grigoriadou M. 
                        ,
                            
Petersen M.B. 
                        ,
                            
Shahin H. 
                        ,
                            
Kanaan M. 
                        ,
                        
                        
                            King M.C. 
                        ,
                            Chen Z.Y. 
                        ,
                            Blanton S.H. 
                        ,
                            Liu X.Z. 
                        ,
                            Zuchner S. 
                        ,
                            Akar N. 
                        ,
                            Tekin M. 
                        
                             
                              more...   
                             
                        
                        
                        
                            Am. J. Hum. Genet.86:797-804(2010)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE 
                    
                    
                 
             
         
            
        
            
                5.
                
                    
                        
                            "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways." 
                        
                        
                            Park J. 
                        ,
                            
Chen Y. 
                        ,
                            
Tishkoff D.X. 
                        ,
                            
Peng C. 
                        ,
                            
Tan M. 
                        ,
                            
Dai L. 
                        ,
                            
Xie Z. 
                        ,
                            
Zhang Y. 
                        ,
                            
Zwaans B.M. 
                        ,
                            
Skinner M.E. 
                        ,
                            
Lombard D.B. 
                        ,
                            
Zhao Y. 
                        
                        
                        
                        
                            Mol. Cell50:919-930(2013)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-197;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] 
                    
                    
                    tissue :
                    
Embryonic fibroblast .