Gene name:
SPINT1 (UNQ223/PRO256;HAI1) ;
Protein name:
Kunitz-type protease inhibitor 1 ;
Alternative:
Hepatocyte growth factor activator inhibitor type 1 (HAI-1) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with HGFAC.
Function:
Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14).
Subcellular Location:
Secreted
Protein Attributes:
50:
MAPARTMARA | RLAPAGIPAV | ALWLLCTLGL | QGTQAGPPPA | PPGLPAGADC |
100:
LNSFTAGVPG | FVLDTNASVS | NGATFLESPT | VRRGWDCVRA | CCTTQNCNLA |
150:
LVELQPDRGE | DAIAACFLIN | CLYEQNFVCK | FAPREGFINY | LTREVYRSYR |
200:
QLRTQGFGGS | GIPKAWAGID | LKVQPQEPLV | LKDVENTDWR | LLRGDTDVRV |
250:
ERKDPNQVEL | WGLKEGTYLF | QLTVTSSDHP | EDTANVTVTV | LSTKQTEDYC |
300:
LASNKVGRCR | GSFPRWYYDP | TEQICKSFVY | GGCLGNKNNY | LREEECILAC |
350:
RGVQGGPLRG | SSGAQATFPQ | GPSMERRHPV | CSGTCQPTQF | RCSNGCCIDS |
400:
FLECDDTPNC | PDASDEAACE | KYTSGFDELQ | RIHFPSDKGH | CVDLPDTGLC |
450:
KESIPRWYYN | PFSEHCARFT | YGGCYGNKNN | FEEEQQCLES | CRGISKKDVF |
500:
GLRREIPIPS | TGSVEMAVAV | FLVICIVVVV | AILGYCFFKN | QRKDFHGHHH |
529:
HPPPTPASST | VSTTEDTEHL | VYNHTTRPL
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
ELISA Kit for Human Kunitz-type protease inhibitor 1
ELISA Kit for Human Kunitz-type protease inhibitor 1
CLIA Kit for Human Kunitz-type protease inhibitor 1
CLIA Kit for Human Kunitz-type protease inhibitor 1
Polyclonal Antibody for Human Kunitz-type protease inhibitor 1
Polyclonal Antibody for Human Kunitz-type protease inhibitor 1
Monoclonal Antibody for Human Kunitz-type protease inhibitor 1
Monoclonal Antibody for Human Kunitz-type protease inhibitor 1
Protein for Human Kunitz-type protease inhibitor 1
Protein for Human Kunitz-type protease inhibitor 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor."
Shimomura T.
,
Denda K.
,
Kitamura A.
,
Kawaguchi T.
,
Kito M.
,
Kondo J.
,
Kagaya S.
,
Qin L.
,
Takata H.
,
Miyazawa K.
,
Kitamura N.
J. Biol. Chem.272:6370-6376(1997)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
2.
"Tissue-expression, protease-specificity and Kunitz domain functions of HAI-1B, a new splice variant of hepatocyte growth factor activator inhibitor-1."
Kirchhofer D.
,
Peek M.
,
Li W.
,
Stamos J.
,
Eigenbrot C.
,
Kadkhodayan S.
,
Eliott J.M.
,
Corpuz R.T.
,
Lazarus R.A.
,
Moran P.
Submitted (2003-06) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
3.
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F.
,
Gurney A.L.
,
Abaya E.
,
Baker K.
,
Baldwin D.T.
,
Brush J.
,
Chen J.
,
Chow B.
,
Chui C.
,
Crowley C.
,
Currell B.
,
Deuel B.
,
Dowd P.
,
Eaton D.
,
Foster J.S.
,
Grimaldi C.
,
Gu Q.
,
Hass P.E.
,
Heldens S.
,
Huang A.
,
Kim H.S.
,
Klimowski L.
,
Jin Y.
,
Johnson S.
,
Lee J.
,
Lewis L.
,
Liao D.
,
Mark M.R.
,
Robbie E.
,
Sanchez C.
,
Schoenfeld J.
,
Seshagiri S.
,
Simmons L.
,
Singh J.
,
Smith V.
,
Stinson J.
,
Vagts A.
,
Vandlen R.L.
,
Watanabe C.
,
Wieand D.
,
Woods K.
,
Xie M.-H.
,
Yansura D.G.
,
Yi S.
,
Yu G.
,
Yuan J.
,
Zhang M.
,
Zhang Z.
,
Goddard A.D.
,
Wood W.I.
,
Godowski P.J.
,
Gray A.M.
more...
Genome Res.13:2265-2270(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
4.
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N.
,
Chen X.
,
Rolfs A.
,
Halleck A.
,
Hines L.
,
Eisenstein S.
,
Koundinya M.
,
Raphael J.
,
Moreira D.
,
Kelley T.
,
LaBaer J.
,
Lin Y.
,
Phelan M.
,
Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Colon .
tissue :
Placenta .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PARTIAL PROTEIN SEQUENCE;CHARACTERIZATION
tissue :
Milk .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 36-50
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 245-303 IN COMPLEX WITH HGFAC;DISULFIDE BONDS