Gene name:
Sphkap (Kiaa1678) ;
Protein name:
A-kinase anchor protein SPHKAP ;
Alternative:
SPHK1-interactor and AKAP domain-containing protein ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts (via the PKA-RII subunit binding domain) with the RI subunit of PKA. Interacts with SPHK1; the interaction greatly reduces SPHK1 activity.
Function:
Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1.
Subcellular Location:
Cytoplasm
Colocalizes with SPHK1 in the cytoplasm.
Protein Attributes:
50:
MDVNSRLSVQ | SNVESPLMHE | GPEPQQITSS | AAGNLAGSIT | ACKKVLRSNS |
100:
LLESTDYWLQ | NQRTPCQIGF | VEDESENCAS | VCFVNLDVNK | DACITENLQQ |
150:
KLVNVSPDLP | NLISSMNVQQ | PKENEIVLLS | GLASGNPQAD | FDVSQCPWLP |
200:
DICLVQCARG | NRPNSTNCII | FEINKFLIGL | EVVQERQLHL | ETNVLKLEDD |
250:
TNCSLSSIEE | DFLTASEHLE | EEIEVDDCRS | GLENTNVSAN | VLESKKPKET |
300:
TQEGWDYHKE | KLHCALGEKH | IRKHRTPSTK | TEGSKENTEE | NTSLKSLNRL |
350:
VRPSHLKSEV | AGNKQLATNY | SYPENIKGEL | ETSQMLFIPR | DAYLSMVKKD |
400:
VLSPCSVLSE | QGGSHRDHDV | TPNPLPPVQN | GEASTGEYAT | NLAESVMQDA |
450:
FIRLSQSQPT | LPQESAVSFS | MRSALLPSGC | CTKDMVVPRS | WNELPKIVIV |
500:
QSPDGSDTVP | EPNVSSWPDM | EFVETSGIFS | ADSSSRPTQS | ALEVALACAA |
550:
TVIGTISSPQ | ATERFAMEQE | SLVSTYAQRG | TGVQQTQVPQ | AFMAPSTTEY |
600:
SFPSALCGMT | QVASAVAVCG | LCEKEEATCP | VAPTDLLPTS | GASEEISSIG |
650:
SLVMERSTEL | GKEAIAEALL | REATLILARP | DAYSSLGELL | ESVNQRIIET |
700:
TSKTQTLCTE | SVQRNELAHT | LSNVILKHSV | DELHQKTTMA | HPTDERHPCG |
750:
TLDTLMESVN | QLLHNVICFT | FKKMNHIVTL | SEHPSFDQAA | GQAWVKAFAC |
800:
PSSQPLSNAH | GTGLVIRNLV | EDASPKSNKG | GARPELVNNP | RLQSEFSCSH |
850:
RMFDSTAKSF | PKEIYLKGIM | GEDTRNPHHT | LNYDSNERRA | STDLGKLTTA |
900:
SEGCSGFQET | EDSIVPNTQE | KYICATPLNN | EAQVNLSLLG | DDLSVPAQST |
950:
LEAKQSEVYG | ITDFAEELAE | TVVSMATEIA | AICLDNSNGK | QPWFCAWKRG |
1000:
NEFLTAPNGS | CRSLKRKKEN | SSAGSTVRKH | KPPRLSEIKR | KADEHPELKE |
1050:
KLMNRVMDES | MNLEDIPDSV | STFANEVAAK | IMNLTEFSMV | DGVWQGQSCS |
1100:
RTRLLGGDRW | NRLKASSCES | IPEEDSEARV | FVNSLGLMST | LSQPVSRASS |
1150:
VSKQSSCESI | TDEFSRFMVK | QMENEGRGFE | LLLDYYAGKN | ASSIMSSAMQ |
1200:
QACQKNDHLN | VRPSCPSKQS | STESITEEFY | RYMLRDIAKE | SKDGASSRRS |
1250:
SHDWTTGLLS | PSTRSPLCYR | QSSMPDSRSP | CSRLTVNAPV | KANSLDGFAQ |
1300:
NCPQDSVNVQ | PVSRASSSGL | CKSDSCLYRR | SGTDQITNML | IHETWASSIE |
1350:
ALMRKNKIIA | DDSEAANASP | GPVSSGSPLQ | VEKNANRLAT | SKGHRGPTLL |
1400:
VQESVDYQRK | DAVTEGNHSP | VSSPGKTAPV | KKPSDFDPRR | ETSACHNAAG |
1450:
LNSPRRSLCS | RDVPLIQIET | DQKEECIGEP | GPFLSQSGSL | EETEGHQPEE |
1500:
TIPDVARNED | TAPSTCQSSR | DSLETSGEVE | VEVLKEDIPR | DESRNPPSSS |
1550:
EESTGSWSQL | ANEEDIPDDT | SSFLQLSERS | MSNGNSSGTS | SLGIMDLDIY |
1600:
QESIPSSPMI | NELVEEKEIL | KEQSESIKEH | ASGLPGRAAS | PQRSLLVINF |
1650:
DLEPECPDAE | LRATLQWIAA | SELGIPTIYF | KKSQESRIEK | FLDVVKLVQQ |
1687:
KSWKVGDIFH | AVVQYCKLHA | EQKERTPSLF | DWLLELG
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Mouse
Human
ELISA Kit for Mouse A-kinase anchor protein SPHKAP
ELISA Kit for Mouse A-kinase anchor protein SPHKAP
ELISA Kit for Mouse A-kinase anchor protein SPHKAP
CLIA Kit for Mouse A-kinase anchor protein SPHKAP
CLIA Kit for Mouse A-kinase anchor protein SPHKAP
CLIA Kit for Mouse A-kinase anchor protein SPHKAP
Polyclonal Antibody for Mouse A-kinase anchor protein SPHKAP
Polyclonal Antibody for Mouse A-kinase anchor protein SPHKAP
Polyclonal Antibody for Mouse A-kinase anchor protein SPHKAP
Monoclonal Antibody for Mouse A-kinase anchor protein SPHKAP
Monoclonal Antibody for Mouse A-kinase anchor protein SPHKAP
Monoclonal Antibody for Mouse A-kinase anchor protein SPHKAP
Protein for Mouse A-kinase anchor protein SPHKAP
Protein for Mouse A-kinase anchor protein SPHKAP
Protein for Mouse A-kinase anchor protein SPHKAP
R&D Technical Data
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Precision
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Recovery
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Linearity
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-868 (ISOFORM 3);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 899-1687 (ISOFORM 1)
strain :
C57BL/6J .
tissue :
Diencephalon .
tissue :
Hypothalamus .
tissue :
Testis .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
strain :
C57BL/6J .
tissue :
Brain .
tissue :
Embryo .
tissue :
Eye .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 288-1687 (ISOFORM 1)
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Brain .