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Index > Protein center > SPARC(Gene name) > Human
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  • SPARC (Gene name),
  • SPARC (Protein name ),  SPRC_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    SPARC(ON);
    Protein name:
    SPARC;
    Alternative:
    Osteonectin(ON);Basement-membrane protein 40(BM-40);Secreted protein acidic and rich in cysteine;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
    Subcellular Location:
    Secreted extracellular space extracellular matrix basement membrane In or around the basement membrane.
    Protein Attributes:
    Sequence length:
    303
    Sequence:
    50:
    MRAWIFFLLC | LAGRALAAPQ | QEALPDETEV | VEETVAEVTE | VSVGANPVQV | 
    100:
    EVGEFDDGAE | ETEEEVVAEN | PCQNHHCKHG | KVCELDENNT | PMCVCQDPTS | 
    150:
    CPAPIGEFEK | VCSNDNKTFD | SSCHFFATKC | TLEGTKKGHK | LHLDYIGPCK | 
    200:
    YIPPCLDSEL | TEFPLRMRDW | LKNVLVTLYE | RDEDNNLLTE | KQKLRVKKIH | 
    250:
    ENEKRLEAGD | HPVELLARDF | EKNYNMYIFP | VHWQFGQLDQ | HPIDGYLSHT | 
    300:
    ELAPLRAPLI | PMEHCTTRFF | ETCDLDNDKY | IALDEWAGCF | GIKQKDIDKD | 
    303:
    LVI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    KEGG:
    String:
    Pfam:
    MIM:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human SPARC
    Cat.:
    E0791h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human SPARC
    Cat.:
    E0791m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human SPARC
    Cat.:
    E0791r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human SPARC
    Cat.:
    E0791b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human SPARC
    Cat.:
    E0791p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human SPARC
    Cat.:
    E0791c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human SPARC
    MSDS:
    Please sign in first.
    CLIA Kit for Human SPARC
    Cat.:
    U0791b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human SPARC
    Cat.:
    U0791p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human SPARC
    Cat.:
    U0791c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human SPARC
    Cat.:
    U0791r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human SPARC
    MSDS:
    Please sign in first.
    CLIA Kit for Human SPARC
    Cat.:
    U0791m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human SPARC
    Cat.:
    U0791h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human SPARC
    Polyclonal Antibody for Human SPARC
    Cat.:
    P0791Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human SPARC
    Polyclonal Antibody for Human SPARC
    Polyclonal Antibody for Human SPARC
    Cat.:
    P0791Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human SPARC
    Polyclonal Antibody for Human SPARC
    Cat.:
    P0791Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human SPARC
    Monoclonal Antibody for Human SPARC
    Monoclonal Antibody for Human SPARC
    Monoclonal Antibody for Human SPARC
    Monoclonal Antibody for Human SPARC
    Monoclonal Antibody for Human SPARC
    Monoclonal Antibody for Human SPARC
    Protein for Human SPARC
    Protein for Human SPARC
    Protein for Human SPARC
    Protein for Human SPARC
    Protein for Human SPARC
    Protein for Human SPARC
    Protein for Human SPARC

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    References
    1. 1.
      "Cloning and complete amino acid sequences of human and murine basement membrane protein BM-40 (SPARC, osteonectin)."
      Lankat-Buttgereit B. , Mann K. , Deutzmann R. , Timpl R. , Krieg T.
      FEBS Lett.236:352-356(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
      tissue: Placenta.
    2. 2.
      "Molecular analysis of the cDNA for human SPARC/osteonectin/BM-40: sequence, expression, and localization of the gene to chromosome 5q31-q33."
      Swaroop A. , Hogan B.L.M. , Francke U.
      Genomics2:37-47(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "Structure of human osteonectin based upon analysis of cDNA and genomic sequences."
      Villarreal X.C. , Mann K.G. , Long G.L.
      Biochemistry28:6483-6491(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "Structure and expression of osteonectin mRNA in human tissue."
      Young M.F. , Day A.A. , Dominquez P. , McQuillan C.I. , Fisher L.W. , Termine J.D.
      Connect. Tissue Res.24:17-28(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    5. 5.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Muscle.
      tissue: PNS.
      tissue: Skin.
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-154
    9. 9.
      "Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone."
      Fisher L.W. , Hawkins G.R. , Tuross N. , Termine J.D.
      J. Biol. Chem.262:9702-9708(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 18-53;CHARACTERIZATION
    10. 10.
      "Human platelet osteonectin: release, surface expression, and partial characterization."
      Kelm R.J. Jr. , Mann K.G.
      Blood75:1105-1113(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 18-41;CHARACTERIZATION;SUBCELLULAR LOCATION
    11. 11.
      "Osteonectin/SPARC/BM-40 in human decidua and carcinoma, tissues characterized by de novo formation of basement membrane."
      Wewer U.M. , Albrechtsen R. , Fisher L.W. , Young M.F. , Termine J.D.
      Am. J. Pathol.132:345-355(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    12. 12.
      "Immunolocalization of SPARC, tenascin, and thrombospondin in pulmonary fibrosis."
      Kuhn C. , Mason R.J.
      Am. J. Pathol.147:1759-1769(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    13. 13.
      "BM-40 (osteonectin, SPARC) is expressed both in the epidermal and in the dermal compartment of adult human skin."
      Hunzelmann N. , Hafner M. , Anders S. , Krieg T. , Nischt R.
      J. Invest. Dermatol.110:122-126(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    14. 14.
      "Structure of a novel extracellular Ca(2+)-binding module in BM-40."
      Hohenester E. , Maurer P. , Hahoenadl C. , Timpl R. , Jansonius J.N. , Engel J.
      Nat. Struct. Biol.3:67-73(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 153-303
    15. 15.
      "Crystal structure of a pair of follistatin-like and EF-hand calcium-binding domains in BM-40."
      Hohenester E. , Maurer P. , Timpl R.
      EMBO J.16:3778-3786(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF 71-303 IN COMPLEX WITH CALCIUM IONS;GLYCOSYLATION AT ASN-116;DISULFIDE BONDS
    16. 16.
      "Crystal structure and mapping by site-directed mutagenesis of the collagen-binding epitope of an activated form of BM-40/SPARC/osteonectin."
      Sasaki T. , Hohenester E. , Gohring W. , Timpl R.
      EMBO J.17:1625-1634(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 71-303 IN COMPLEX WITH CALCIUM IONS;GLYCOSYLATION AT ASN-116;INTERACTION WITH COLLAGEN;MUTAGENESIS OF ARG-166; ASN-173; LEU-259; MET-262 AND GLU-263
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