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Index > Protein center > Spsb1(Gene name) > Mouse
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  • Spsb1 (Gene name),
  • SPRY domain-containing SOCS box protein 1 (Protein name ),  SPSB1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Spsb1(Ssb1);
    Protein name:
    SPRY domain-containing SOCS box protein 1(SSB-1);
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Component of the probable ECS(SPSB1) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and SPSB1. Interacts with CUL5, RNF7, TCEB1 and TCEB2 (By similarity). Interacts with PARW. Directly interacts with MET tyrosine kinase domain in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. When phosphorylated, interacts with RASA1 without affecting its stability.
    Function:
    Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    273
    Sequence:
    50:
    MGQKVTGGIK | TVDMRDPTYR | PLKQELQGLD | YCKPTRLDLL | LDMPPVSYDV | 
    100:
    QLLHSWNNND | RSLNVFVKED | DKLIFHRHPV | AQSTDAIRGK | VGYTRGLHVW | 
    150:
    QITWAMRQRG | THAVVGVATA | DAPLHSVGYT | TLVGNNHESW | GWDLGRNRLY | 
    200:
    HDGKNQPSKT | YPAFLEPDET | FIVPDSFLVA | LDMDDGTLSF | IVDGQYMGVA | 
    250:
    FRGLKGKKLY | PVVSAVWGHC | EIRMRYLNGL | DPEPLPLMDL | CRRSVRLALG | 
    273:
    KERLGAIPAL | PLPASLKAYL | LYQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    UniGene:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse SSB-1
    ELISA Kit for Mouse SSB-1
    ELISA Kit for Mouse SSB-1
    CLIA Kit for Mouse SSB-1
    CLIA Kit for Mouse SSB-1
    CLIA Kit for Mouse SSB-1
    Polyclonal Antibody for Mouse SSB-1
    Polyclonal Antibody for Mouse SSB-1
    Polyclonal Antibody for Mouse SSB-1
    Monoclonal Antibody for Mouse SSB-1
    Monoclonal Antibody for Mouse SSB-1
    Monoclonal Antibody for Mouse SSB-1
    Protein for Mouse SSB-1
    Protein for Mouse SSB-1
    Protein for Mouse SSB-1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "SOCS box proteins."
      Friedel E.J. , Nicholson S.E. , Nicola N.A. , Kile B.T. , Hilton D.J.
      Submitted (2001-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: C57BL/6J.
      strain: NOD.
      tissue: Aorta.
      tissue: Embryo.
      tissue: Pituitary anterior lobe.
      tissue: Spleen.
      tissue: Testis.
      tissue: Vein.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      strain: C57BL/6.
      tissue: Eye.
    4. 4.
      "The SPRY domain of SSB-2 adopts a novel fold that presents conserved Par-4-binding residues."
      Masters S.L. , Yao S. , Willson T.A. , Zhang J.-G. , Palmer K.R. , Smith B.J. , Babon J.J. , Nicola N.A. , Norton R.S. , Nicholson S.E.
      Nat. Struct. Mol. Biol.13:77-84(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PAWR AND MET
    5. 5.
      "Structural and functional insights into the B30.2/SPRY domain."
      Woo J.S. , Imm J.H. , Min C.K. , Kim K.J. , Cha S.S. , Oh B.H.
      EMBO J.25:1353-1363(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ELONGIN BC COMPLEX
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