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Index > Protein center > Spsb2(Gene name) > Mouse
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  • Spsb2 (Gene name),
  • SPRY domain-containing SOCS box protein 2 (Protein name ),  SPSB2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Spsb2(Grcc9;Ssb2);
    Protein name:
    SPRY domain-containing SOCS box protein 2(SSB-2);
    Alternative:
    Gene-rich cluster protein C9;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with PARW and MET. Component of the probable ECS(SPSB2) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and SPSB2. Interacts with CUL5, RNF7, TCEB1 and TCEB2.
    Function:
    Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    264
    Sequence:
    50:
    MGQTALARGS | SSTPTSQALY | SDFSPPEGLE | ELLSAPPPDL | VAQRHHGWNP | 
    100:
    KDCSENIDVK | EGGLCFERRP | VAQSTDGVRG | KRGYSRGLHA | WEISWPLEQR | 
    150:
    GTHAVVGVAT | ALAPLQADHY | AALLGSNSES | WGWDIGRGKL | YHQSKGLEAP | 
    200:
    QYPAGPQGEQ | LVVPERLLVV | LDMEEGTLGY | SIGGTYLGPA | FRGLKGRTLY | 
    250:
    PSVSAVWGQC | QVRIRYMGER | RVEEPQSLLH | LSRLCVRHAL | GDTRLGQIST | 
    264:
    LPLPPAMKRY | LLYK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse SSB-2
    ELISA Kit for Mouse SSB-2
    ELISA Kit for Mouse SSB-2
    CLIA Kit for Mouse SSB-2
    CLIA Kit for Mouse SSB-2
    CLIA Kit for Mouse SSB-2
    Polyclonal Antibody for Mouse SSB-2
    Polyclonal Antibody for Mouse SSB-2
    Polyclonal Antibody for Mouse SSB-2
    Monoclonal Antibody for Mouse SSB-2
    Monoclonal Antibody for Mouse SSB-2
    Monoclonal Antibody for Mouse SSB-2
    Protein for Mouse SSB-2
    Protein for Mouse SSB-2
    Protein for Mouse SSB-2

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6."
      Ansari-Lari M.A. , Oeltjen J.C. , Schwartz S. , Zhang Z. , Muzny D.M. , Lu J. , Gorrell J.H. , Chinault A.C. , Belmont J.W. , Miller W. , Gibbs R.A.
      Genome Res.8:29-40(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "SOCS box proteins."
      Friedel E.J. , Nicholson S.E. , Nicola N.A. , Kile B.T. , Hilton D.J.
      Submitted (2001-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: C57BL/6J.
      tissue: Bone.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      strain: FVB/N.
      tissue: Mammary gland.
      tissue: Mammary tumor.
    5. 5.
      "The SPRY domain of SSB-2 adopts a novel fold that presents conserved Par-4-binding residues."
      Masters S.L. , Yao S. , Willson T.A. , Zhang J.-G. , Palmer K.R. , Smith B.J. , Babon J.J. , Nicola N.A. , Norton R.S. , Nicholson S.E.
      Nat. Struct. Mol. Biol.13:77-84(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 12-224;INTERACTION WITH PAWR AND MET;MUTAGENESIS OF TYR-120; 123-LEU--GLY-125; 141-TYR--GLN-143; 151-GLN-TYR-152; 188-GLY-PRO-189 AND VAL-206
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