Gene name:
SRRT (ARS2;ASR2) ;
Protein name:
Serrate RNA effector molecule homolog ;
Alternative:
Arsenite-resistance protein 2 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with NCBP1 and DROSHA (By similarity). Interacts with CASP8AP2 and ERBB4.
Function:
Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity.
Subcellular Location:
Nucleus
nucleoplasm
Cytoplasm
Predominantly nuclear. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent way.
Protein Attributes:
50:
MGDSDDEYDR | RRRDKFRRER | SDYDRSRERD | ERRRGDDWND | REWDRGRERR |
100:
SRGEYRDYDR | NRRERFSPPR | HELSPPQKRM | RRDWDEHSSD | PYHSGYEMPY |
150:
AGGGGGPTYG | PPQPWGHPDV | HIMQHHVLPI | QARLGSIAEI | DLGVPPPVMK |
200:
TFKEFLLSLD | DSVDETEAVK | RYNDYKLDFR | RQQMQDFFLA | HKDEEWFRSK |
250:
YHPDEVGKRR | QEARGALQNR | LRVFLSLMET | GWFDNLLLDI | DKADAIVKML |
300:
DAAVIKMEGG | TENDLRILEQ | EEEEEQAGKP | GEPSKKEEGR | AGAGLGDGER |
350:
KTNDKDEKKE | DGKQAENDSS | NDDKTKKSEG | DGDKEEKKED | SEKEAKKSSK |
400:
KRNRKHSGDD | SFDEGSVSES | ESESESGQAE | EEKEEAEEAL | KEKEKPKEEE |
450:
WEKPKDAAGL | ECKPRPLHKT | CSLFMRNIAP | NISRAEIISL | CKRYPGFMRV |
500:
ALSEPQPERR | FFRRGWVTFD | RSVNIKEICW | NLQNIRLREC | ELSPGVNRDL |
550:
TRRVRNINGI | TQHKQIVRND | IKLAAKLIHT | LDDRTQLWAS | EPGTPPLPTS |
600:
LPSQNPILKN | ITDYLIEEVS | AEEEELLGSS | GGAPPEEPPK | EGNPAEINVE |
650:
RDEKLIKVLD | KLLLYLRIVH | SLDYYNTCEY | PNEDEMPNRC | GIIHVRGPMP |
700:
PNRISHGEVL | EWQKTFEEKL | TPLLSVRESL | SEEEAQKMGR | KDPEQEVEKF |
750:
VTSNTQELGK | DKWLCPLSGK | KFKGPEFVRK | HIFNKHAEKI | EEVKKEVAFF |
800:
NNFLTDAKRP | ALPEIKPAQP | PGPAQILPPG | LTPGLPYPHQ | TPQGLMPYGQ |
850:
PRPPILGYGA | GAVRPAVPTG | GPPYPHAPYG | AGRGNYDAFR | GQGGYPGKPR |
876:
NRMVRGDPRA | IVEYRDLDAP | DDVDFF
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Bovine
Human
ELISA Kit for Human Serrate RNA effector molecule homolog
ELISA Kit for Human Serrate RNA effector molecule homolog
ELISA Kit for Human Serrate RNA effector molecule homolog
CLIA Kit for Human Serrate RNA effector molecule homolog
CLIA Kit for Human Serrate RNA effector molecule homolog
CLIA Kit for Human Serrate RNA effector molecule homolog
Polyclonal Antibody for Human Serrate RNA effector molecule homolog
Polyclonal Antibody for Human Serrate RNA effector molecule homolog
Polyclonal Antibody for Human Serrate RNA effector molecule homolog
Monoclonal Antibody for Human Serrate RNA effector molecule homolog
Monoclonal Antibody for Human Serrate RNA effector molecule homolog
Monoclonal Antibody for Human Serrate RNA effector molecule homolog
Protein for Human Serrate RNA effector molecule homolog
Protein for Human Serrate RNA effector molecule homolog
Protein for Human Serrate RNA effector molecule homolog
R&D Technical Data
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Precision
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Recovery
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Linearity
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more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 65-876 (ISOFORM 1)
tissue :
Brain .
tissue :
Kidney .
9.
Hu G.
Submitted (1998-08) to the EMBL/GenBank/DDBJ databases
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 443-876 (ISOFORMS 2/3)
10.
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Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-8; SER-493 AND THR-544;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
11.
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Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-540;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-544;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
13.
"Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction."
Tang L.-Y.
,
Deng N.
,
Wang L.-S.
,
Dai J.
,
Wang Z.-L.
,
Jiang X.-S.
,
Li S.-J.
,
Li L.
,
Sheng Q.-H.
,
Wu D.-Q.
,
Li L.
,
Zeng R.
Mol. Cell. Proteomics6:1952-1967(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-544;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Embryonic kidney .
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-493;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
15.
"ARS2 is a conserved eukaryotic gene essential for early mammalian development."
Wilson M.D.
,
Wang D.
,
Wagner R.
,
Breyssens H.
,
Gertsenstein M.
,
Lobe C.
,
Lu X.
,
Nagy A.
,
Burke R.D.
,
Koop B.F.
,
Howard P.L.
Mol. Cell. Biol.28:1503-1514(2008)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-540 AND THR-544;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
17.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.
"Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation."
Gruber J.J.
,
Zatechka D.S.
,
Sabin L.R.
,
Yong J.
,
Lum J.J.
,
Kong M.
,
Zong W.-X.
,
Zhang Z.
,
Lau C.-K.
,
Rawlings J.
,
Cherry S.
,
Ihle J.N.
,
Dreyfuss G.
,
Thompson C.B.
Cell138:328-339(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
19.
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Cited for : INTERACTION WITH CASP8AP2
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-544;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
21.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY;INTERACTION WITH ERBB4;SUBCELLULAR LOCATION
22.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V.
,
Vermeulen M.
,
Santamaria A.
,
Kumar C.
,
Miller M.L.
,
Jensen L.J.
,
Gnad F.
,
Cox J.
,
Jensen T.S.
,
Nigg E.A.
,
Brunak S.
,
Mann M.
Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT GLY-2;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; SER-74; SER-493 AND THR-544;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT GLY-2;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4 AND THR-544;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]