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Index > Protein center > SRRT(Gene name) > Human
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  • SRRT (Gene name),
  • Serrate RNA effector molecule homolog (Protein name ),  SRRT_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    SRRT(ARS2;ASR2);
    Protein name:
    Serrate RNA effector molecule homolog;
    Alternative:
    Arsenite-resistance protein 2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with NCBP1 and DROSHA (By similarity). Interacts with CASP8AP2 and ERBB4.
    Function:
    Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity.
    Subcellular Location:
    Nucleus nucleoplasm Cytoplasm Predominantly nuclear. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent way.
    Protein Attributes:
    Sequence length:
    876
    Sequence:
    50:
    MGDSDDEYDR | RRRDKFRRER | SDYDRSRERD | ERRRGDDWND | REWDRGRERR | 
    100:
    SRGEYRDYDR | NRRERFSPPR | HELSPPQKRM | RRDWDEHSSD | PYHSGYEMPY | 
    150:
    AGGGGGPTYG | PPQPWGHPDV | HIMQHHVLPI | QARLGSIAEI | DLGVPPPVMK | 
    200:
    TFKEFLLSLD | DSVDETEAVK | RYNDYKLDFR | RQQMQDFFLA | HKDEEWFRSK | 
    250:
    YHPDEVGKRR | QEARGALQNR | LRVFLSLMET | GWFDNLLLDI | DKADAIVKML | 
    300:
    DAAVIKMEGG | TENDLRILEQ | EEEEEQAGKP | GEPSKKEEGR | AGAGLGDGER | 
    350:
    KTNDKDEKKE | DGKQAENDSS | NDDKTKKSEG | DGDKEEKKED | SEKEAKKSSK | 
    400:
    KRNRKHSGDD | SFDEGSVSES | ESESESGQAE | EEKEEAEEAL | KEKEKPKEEE | 
    450:
    WEKPKDAAGL | ECKPRPLHKT | CSLFMRNIAP | NISRAEIISL | CKRYPGFMRV | 
    500:
    ALSEPQPERR | FFRRGWVTFD | RSVNIKEICW | NLQNIRLREC | ELSPGVNRDL | 
    550:
    TRRVRNINGI | TQHKQIVRND | IKLAAKLIHT | LDDRTQLWAS | EPGTPPLPTS | 
    600:
    LPSQNPILKN | ITDYLIEEVS | AEEEELLGSS | GGAPPEEPPK | EGNPAEINVE | 
    650:
    RDEKLIKVLD | KLLLYLRIVH | SLDYYNTCEY | PNEDEMPNRC | GIIHVRGPMP | 
    700:
    PNRISHGEVL | EWQKTFEEKL | TPLLSVRESL | SEEEAQKMGR | KDPEQEVEKF | 
    750:
    VTSNTQELGK | DKWLCPLSGK | KFKGPEFVRK | HIFNKHAEKI | EEVKKEVAFF | 
    800:
    NNFLTDAKRP | ALPEIKPAQP | PGPAQILPPG | LTPGLPYPHQ | TPQGLMPYGQ | 
    850:
    PRPPILGYGA | GAVRPAVPTG | GPPYPHAPYG | AGRGNYDAFR | GQGGYPGKPR | 
    876:
    NRMVRGDPRA | IVEYRDLDAP | DDVDFF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    SMR:
    String:
    MIM:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Serrate RNA effector molecule homolog
    ELISA Kit for Human Serrate RNA effector molecule homolog
    ELISA Kit for Human Serrate RNA effector molecule homolog
    CLIA Kit for Human Serrate RNA effector molecule homolog
    CLIA Kit for Human Serrate RNA effector molecule homolog
    CLIA Kit for Human Serrate RNA effector molecule homolog
    Polyclonal Antibody for Human Serrate RNA effector molecule homolog
    Polyclonal Antibody for Human Serrate RNA effector molecule homolog
    Polyclonal Antibody for Human Serrate RNA effector molecule homolog
    Monoclonal Antibody for Human Serrate RNA effector molecule homolog
    Monoclonal Antibody for Human Serrate RNA effector molecule homolog
    Monoclonal Antibody for Human Serrate RNA effector molecule homolog
    Protein for Human Serrate RNA effector molecule homolog
    Protein for Human Serrate RNA effector molecule homolog
    Protein for Human Serrate RNA effector molecule homolog

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    References
    1. 1.
      "Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5."
      Wilson M.D. , Riemer C. , Martindale D.W. , Schnupf P. , Boright A.P. , Cheung T.L. , Hardy D.M. , Schwartz S. , Scherer S.W. , Tsui L.-C. , Miller W. , Koop B.F.
      Nucleic Acids Res.29:1352-1365(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];ALTERNATIVE SPLICING (ISOFORMS 1 AND 2)
    2. 2.
      "Cloning and bioinformatic characterization of the full length human homologous asr2 gene."
      Yang L. , Huang J. , Ying K. , Pan Z.M. , Gu Y.Q. , Wang G.Q. , Lin S. , Wu H. , Yang Q.S. , Xie Y. , Mao Y.M.
      Submitted (2000-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Brain.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)
      tissue: Testis.
      tissue: Thalamus.
    5. 5.
      "The DNA sequence of human chromosome 7."
      Hillier L.W. , Fulton R.S. , Fulton L.A. , Graves T.A. , Pepin K.H. , Wagner-McPherson C. , Layman D. , Maas J. , Jaeger S. , Walker R. , Wylie K. , Sekhon M. , Becker M.C. , O'Laughlin M.D. , Schaller M.E. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , more...
      Nature424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 65-876 (ISOFORM 1)
      tissue: Brain.
      tissue: Kidney.
    8. 9.
      Hu G.
      Submitted (1998-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 443-876 (ISOFORMS 2/3)
    9. 10.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-8; SER-493 AND THR-544;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    10. 11.
      "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A. , Villen J. , Gerber S.A. , Rush J. , Gygi S.P.
      Nat. Biotechnol.24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-540;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    11. 12.
      "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
      Yu L.R. , Zhu Z. , Chan K.C. , Issaq H.J. , Dimitrov D.S. , Veenstra T.D.
      J. Proteome Res.6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-544;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    12. 13.
      "Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction."
      Tang L.-Y. , Deng N. , Wang L.-S. , Dai J. , Wang Z.-L. , Jiang X.-S. , Li S.-J. , Li L. , Sheng Q.-H. , Wu D.-Q. , Li L. , Zeng R.
      Mol. Cell. Proteomics6:1952-1967(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-544;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic kidney.
    13. 14.
      "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T. , Yi W. , Lu B. , Park S.K. , Xu T. , Lee J.-D. , Yates J.R. III
      J. Proteome Res.7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-493;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    14. 15.
      "ARS2 is a conserved eukaryotic gene essential for early mammalian development."
      Wilson M.D. , Wang D. , Wagner R. , Breyssens H. , Gertsenstein M. , Lobe C. , Lu X. , Nagy A. , Burke R.D. , Koop B.F. , Howard P.L.
      Mol. Cell. Biol.28:1503-1514(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    15. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-540 AND THR-544;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    16. 17.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    17. 18.
      "Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation."
      Gruber J.J. , Zatechka D.S. , Sabin L.R. , Yong J. , Lum J.J. , Kong M. , Zong W.-X. , Zhang Z. , Lau C.-K. , Rawlings J. , Cherry S. , Ihle J.N. , Dreyfuss G. , Thompson C.B.
      Cell138:328-339(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    18. 19.
      "Interaction of FLASH with arsenite resistance protein 2 is involved in cell cycle progression at S phase."
      Kiriyama M. , Kobayashi Y. , Saito M. , Ishikawa F. , Yonehara S.
      Mol. Cell. Biol.29:4729-4741(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CASP8AP2
    19. 20.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-544;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    20. 21.
      "Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways."
      Gilmore-Hebert M. , Ramabhadran R. , Stern D.F.
      Mol. Cancer Res.8:1388-1398(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;INTERACTION WITH ERBB4;SUBCELLULAR LOCATION
    21. 22.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT GLY-2;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; SER-74; SER-493 AND THR-544;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    22. 23.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    23. 24.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT GLY-2;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4 AND THR-544;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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