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Index > Protein center > Srsf2(Gene name) > Mouse
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  • Srsf2 (Gene name),
  • Serine/arginine-rich splicing factor 2 (Protein name ),  SRSF2_MOUSE from NCBI database.
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  • Gene name:
    Srsf2(Pr264;Sfrs10;Sfrs2);
    Protein name:
    Serine/arginine-rich splicing factor 2;
    Alternative:
    Putative myelin regulatory factor 1(MRF-1);Protein PR264;Splicing factor SC35(SC-35);Splicing component, 35 kDa;Splicing factor, arginine/serine-rich 2;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with CCNL1 and CCNL2. Interacts with SCAF11. Interacts with ZRSR2/U2AF1-RS2. Interacts with CCDC55 (via C-terminus) (By similarity). In vitro, self-associates and binds SRSF1/SFRS1 (ASF/SF2), SNRNP70 and U2AF1 but not U2AF2. Binds SREK1/SFRS12.
    Function:
    Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA (By similarity). Can bind to the myelin basic protein (MBP) gene MB3 regulatory region and increase transcription of the mbp promoter in cells derived from the CNS.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    221
    Sequence:
    50:
    MSYGRPPPDV | EGMTSLKVDN | LTYRTSPDTL | RRVFEKYGRV | GDVYIPRDRY | 
    100:
    TKESRGFAFV | RFHDKRDAED | AMDAMDGAVL | DGRELRVQMA | RYGRPPDSHH | 
    150:
    SRRGPPPRRY | GGGGYGRRSR | SPRRRRRSRS | RSRSRSRSRS | RSRYSRSKSR | 
    200:
    SRTRSRSRST | SKSRSARRSK | SKSSSVSRSR | SRSRSRSRSR | SPPPVSKRES | 
    221:
    KSRSRSKSPP | KSPEEEGAVS | S
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    String:
    SMR:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Serine/arginine-rich splicing factor 2
    Cat.:
    E11550h
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    96T
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    ELISA Kit for Mouse Serine/arginine-rich splicing factor 2
    MSDS:
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    ELISA Kit for Mouse Serine/arginine-rich splicing factor 2
    MSDS:
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    ELISA Kit for Mouse Serine/arginine-rich splicing factor 2
    MSDS:
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    ELISA Kit for Mouse Serine/arginine-rich splicing factor 2
    Cat.:
    E11550m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse Serine/arginine-rich splicing factor 2
    Cat.:
    E11550r
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    Packing:
    96T
    CLIA Kit for Mouse Serine/arginine-rich splicing factor 2
    MSDS:
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    CLIA Kit for Mouse Serine/arginine-rich splicing factor 2
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse Serine/arginine-rich splicing factor 2
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse Serine/arginine-rich splicing factor 2
    Cat.:
    U11550h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Serine/arginine-rich splicing factor 2
    Cat.:
    U11550r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Serine/arginine-rich splicing factor 2
    Cat.:
    U11550m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Serine/arginine-rich splicing factor 2
    Cat.:
    P11550Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Serine/arginine-rich splicing factor 2
    Polyclonal Antibody for Mouse Serine/arginine-rich splicing factor 2
    Polyclonal Antibody for Mouse Serine/arginine-rich splicing factor 2
    Polyclonal Antibody for Mouse Serine/arginine-rich splicing factor 2
    Polyclonal Antibody for Mouse Serine/arginine-rich splicing factor 2
    Monoclonal Antibody for Mouse Serine/arginine-rich splicing factor 2
    Monoclonal Antibody for Mouse Serine/arginine-rich splicing factor 2
    Monoclonal Antibody for Mouse Serine/arginine-rich splicing factor 2
    Monoclonal Antibody for Mouse Serine/arginine-rich splicing factor 2
    Monoclonal Antibody for Mouse Serine/arginine-rich splicing factor 2
    Monoclonal Antibody for Mouse Serine/arginine-rich splicing factor 2
    Protein for Mouse Serine/arginine-rich splicing factor 2
    Protein for Mouse Serine/arginine-rich splicing factor 2
    Protein for Mouse Serine/arginine-rich splicing factor 2
    Protein for Mouse Serine/arginine-rich splicing factor 2
    Protein for Mouse Serine/arginine-rich splicing factor 2
    Protein for Mouse Serine/arginine-rich splicing factor 2

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    References
    1. 1.
      "Isolation and characterization of MRF-1, a brain-derived DNA-binding protein with a capacity to regulate expression of myelin basic protein gene."
      Haque N.S. , Buchberg A.M. , Khalili K.
      J. Biol. Chem.269:31149-31156(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION IN MBP REGULATION;TISSUE SPECIFICITY
      tissue: Brain.
    2. 2.
      "Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing."
      Yang L. , Embree L.J. , Tsai S. , Hickstein D.D.
      J. Biol. Chem.273:27761-27764(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: NOD.
      tissue: Bone marrow.
      tissue: Thymus.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Mammary gland.
    5. 5.
      Gaillard C. , Perbal B.
      Submitted (1996-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-121
      strain: 129/Sv.
      tissue: Liver.
    6. 6.
      "The testis-specific double bromodomain-containing protein BRDT forms a complex with multiple spliceosome components and is required for mRNA splicing and 3'-UTR truncation in round spermatids."
      Berkovits B.D. , Wang L. , Guarnieri P. , Wolgemuth D.J.
      Nucleic Acids Res.40:7162-7175(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BRDT
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