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Index > Protein center > SULT1A1(Gene name) > Human
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  • SULT1A1 (Gene name),
  • Sulfotransferase 1A1 (Protein name ),  ST1A1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    SULT1A1(OK/SW-cl.88;STP;STP1);
    Protein name:
    Sulfotransferase 1A1(ST1A1);
    Alternative:
    HAST1/HAST2;Aryl sulfotransferase 1;Phenol-sulfating phenol sulfotransferase 1(P-PST 1);Phenol sulfotransferase 1;Thermostable phenol sulfotransferase(Ts-PST);ST1A3;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    Catalyzes the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    295
    Sequence:
    50:
    MELIQDTSRP | PLEYVKGVPL | IKYFAEALGP | LQSFQARPDD | LLISTYPKSG | 
    100:
    TTWVSQILDM | IYQGGDLEKC | HRAPIFMRVP | FLEFKAPGIP | SGMETLKDTP | 
    150:
    APRLLKTHLP | LALLPQTLLD | QKVKVVYVAR | NAKDVAVSYY | HFYHMAKVHP | 
    200:
    EPGTWDSFLE | KFMVGEVSYG | SWYQHVQEWW | ELSRTHPVLY | LFYEDMKENP | 
    250:
    KREIQKILEF | VGRSLPEETV | DFVVQHTSFK | EMKKNPMTNY | TTVPQEFMDH | 
    295:
    SISPFMRKGM | AGDWKTTFTV | AQNERFDADY | AEKMAGCSLS | FRSEL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    UniGene:
    Pfam:
    SMR:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human ST1A1
    Cat.:
    E14887h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human ST1A1
    MSDS:
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    ELISA Kit for Human ST1A1
    MSDS:
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    ELISA Kit for Human ST1A1
    Cat.:
    E14887m
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human ST1A1
    MSDS:
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    CLIA Kit for Human ST1A1
    MSDS:
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    CLIA Kit for Human ST1A1
    Cat.:
    U14887m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human ST1A1
    MSDS:
    Please sign in first.
    CLIA Kit for Human ST1A1
    MSDS:
    Please sign in first.
    CLIA Kit for Human ST1A1
    Cat.:
    U14887h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    Polyclonal Antibody for Human ST1A1
    Polyclonal Antibody for Human ST1A1
    Polyclonal Antibody for Human ST1A1
    Polyclonal Antibody for Human ST1A1
    Polyclonal Antibody for Human ST1A1
    Monoclonal Antibody for Human ST1A1
    Monoclonal Antibody for Human ST1A1
    Monoclonal Antibody for Human ST1A1
    Monoclonal Antibody for Human ST1A1
    Monoclonal Antibody for Human ST1A1
    Protein for Human ST1A1
    Protein for Human ST1A1
    Protein for Human ST1A1
    Protein for Human ST1A1
    Protein for Human ST1A1

    R&D Technical Data
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    Precision
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    Linearity
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    References
    1. 1.
      "Identification of two human brain aryl sulfotransferase cDNAs."
      Zhu X. , Veronese M.E. , Bernard C.C. , Sansom L.N. , McManus M.E.
      Biochem. Biophys. Res. Commun.195:120-127(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT MET-223
      tissue: Brain.
    2. 2.
      "Molecular characterisation of a human aryl sulfotransferase cDNA."
      Zhu X. , Veronese M.E. , Sansom L.N. , McManus M.E.
      Biochem. Biophys. Res. Commun.192:671-676(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT MET-223
      tissue: Liver.
    3. 3.
      "Sequence analysis and expression of the cDNA for the phenol-sulfating form of human liver phenol sulfotransferase."
      Wilborn T.W. , Comer K.A. , Dooley T.P. , Reardon I.M. , Heinrikson R.L. , Falany C.N.
      Mol. Pharmacol.43:70-77(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PARTIAL PROTEIN SEQUENCE;VARIANTS MET-223 AND LYS-282
      tissue: Liver.
    4. 4.
      "Structural similarity and diversity of sulfotransferases."
      Yamazoe Y. , Nagata K. , Ozawa S. , Kato R.
      Chem. Biol. Interact.92:107-117(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT MET-223
    5. 5.
      "Molecular cloning of an isoform of phenol sulfotransferase from human brain hippocampus."
      Hwang S.-R. , Kohn A.B. , Hook V.Y.H.
      Biochem. Biophys. Res. Commun.207:701-707(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT MET-223
      tissue: Hippocampus.
    6. 6.
      "Human platelet phenolsulfotransferases: cDNA cloning, stable expression in V79 cells and identification of a novel allelic variant of the phenol-sulfating form."
      Jones A.L. , Hagen M. , Coughtrie M.W.H. , Roberts R.C. , Glatt H.
      Biochem. Biophys. Res. Commun.208:855-862(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT MET-223
      tissue: Blood.
    7. 7.
      "Primary structures and properties of two related forms of aryl sulfotransferases in human liver."
      Ozawa S. , Nagata K. , Shimada M. , Ueda M. , Tsuzuki T. , Yamazoe Y. , Kato R.
      Pharmacogenetics5:S135-S140(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT MET-223
      tissue: Liver.
    8. 8.
      "Genomic organization and DNA sequences of two human phenol sulfotransferase genes (STP1 and STP2) on the short arm of chromosome 16."
      Dooley T.P. , Huang Z.
      Biochem. Biophys. Res. Commun.228:134-140(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1);VARIANT MET-223
    9. 9.
      "Human phenol sulfotransferase gene contains two alternative promoters: structure and expression of the gene."
      Bernier F. , Soucy P. , Luu-The V.
      DNA Cell Biol.15:367-375(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1);VARIANTS MET-223 AND LYS-282
    10. 10.
      "A single amino acid, Glu146, governs the substrate specificity of a human dopamine sulfotransferase, SULT1A3."
      Dajani R. , Hood A.M. , Coughtrie M.W.
      Mol. Pharmacol.54:942-948(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT MET-223
      tissue: Liver.
    11. 11.
      Raftogianis R.B. , Her C. , Weinshilboum R.M.
      Submitted (1997-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1);VARIANT MET-223
    12. 12.
      "Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients."
      Shichijo S. , Itoh K.
      Submitted (2001-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS HIS-213 AND MET-223
      tissue: Colon adenocarcinoma.
    13. 13.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT HIS-213
    14. 14.
      "Full-length cDNA libraries and normalization."
      Li W.B. , Gruber C. , Jessee J. , Polayes D.
      Submitted (2004-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    15. 15.
      "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
      Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    16. 16.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT MET-223
      tissue: Colon.
      tissue: Placenta.
    17. 17.
      "Mapping of the phenol sulfotransferase gene (STP) to human chromosome 16p12.1-p11.2 and to mouse chromosome 7."
      Dooley T.P. , Obermoeller R.D. , Leiter E.H. , Chapman H.D. , Falany C.N. , Deng Z. , Siciliano M.J.
      Genomics18:440-443(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-107 (ISOFORM 1)
    18. 18.
      "Functional characterization of two human sulphotransferase cDNAs that encode monoamine- and phenol-sulphating forms of phenol sulphotransferase: substrate kinetics, thermal-stability and inhibitor-sensitivity studies."
      Veronese M.E. , Burgess W. , Zhu X. , McManus M.E.
      Biochem. J.302:497-502(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
    19. 19.
      "Characterization of expressed human phenol-sulfating phenol sulfotransferase: effect of mutating cys70 on activity and thermostability."
      Falany C.N. , Zhuang W. , Falany J.L.
      Chem. Biol. Interact.92:57-66(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF CYS-70
    20. 20.
      "Structure of a human carcinogen-converting enzyme, SULT1A1. Structural and kinetic implications of substrate inhibition."
      Gamage N.U. , Duggleby R.G. , Barnett A.C. , Tresillian M. , Latham C.F. , Liyou N.E. , McManus M.E. , Martin J.L.
      J. Biol. Chem.278:7655-7662(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) IN COMPLEX WITH ADENOSINE-3'-5'-DIPHOSPHATE (PAP) AND P-NITROPHENOL;CATALYTIC ACTIVITY;FUNCTION
    21. 21.
      "The structure of human SULT1A1 crystallized with estradiol. An insight into active site plasticity and substrate inhibition with multi-ring substrates."
      Gamage N.U. , Tsvetanov S. , Duggleby R.G. , McManus M.E. , Martin J.L.
      J. Biol. Chem.280:41482-41486(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) IN COMPLEX WITH ADENOSINE-3'-5'-DIPHOSPHATE AND ESTRADIOL;CATALYTIC ACTIVITY;FUNCTION
    22. 22.
      "Crystal structures of SULT1A2 and SULT1A1 *3: insights into the substrate inhibition and the role of Tyr149 in SULT1A2."
      Lu J. , Li H. , Zhang J. , Li M. , Liu M.Y. , An X. , Liu M.C. , Chang W.
      Biochem. Biophys. Res. Commun.396:429-434(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) IN COMPLEX WITH ADENOSINE-3'-5'-DIPHOSPHATE
    23. 23.
      "Directed evolution of sulfotransferases and paraoxonases by ancestral libraries."
      Alcolombri U. , Elias M. , Tawfik D.S.
      J. Mol. Biol.411:837-853(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) IN COMPLEXES WITH ADENOSINE-3'-5'-DIPHOSPHATE AND P-NITROPHENOL;CATALYTIC ACTIVITY
    24. 24.
      "The molecular basis for the broad substrate specificity of human sulfotransferase 1A1."
      Berger I. , Guttman C. , Amar D. , Zarivach R. , Aharoni A.
      PLoS ONE6:E26794-E26794(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEXES WITH ADENOSINE-3'-5'-DIPHOSPHATE AND P-NITROPHENOL;CATALYTIC ACTIVITY
    25. 25.
      "Phenol sulfotransferase pharmacogenetics in humans: association of common SULT1A1 alleles with TS PST phenotype."
      Raftogianis R.B. , Wood T.C. , Otterness D.M. , Van Loon J.A. , Weinshilboum R.M.
      Biochem. Biophys. Res. Commun.239:298-304(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GLN-37; HIS-213 AND MET-223
    26. 26.
      "Association between functional genetic polymorphisms of human sulfotransferases 1A1 and 1A2."
      Engelke C.E. , Meinl W. , Boeing H. , Glatt H.
      Pharmacogenetics10:163-169(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HIS-213
    27. 27.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-223;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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