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Index > Protein center > ST5(Gene name) > Human
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  • ST5 (Gene name),
  • Suppression of tumorigenicity 5 protein (Protein name ),  ST5_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ST5(DENND2B;HTS1);
    Protein name:
    Suppression of tumorigenicity 5 protein;
    Alternative:
    HeLa tumor suppression 1;DENN domain-containing protein 2B;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Isoform 1 interacts with the SH3 domain of ABL1.
    Function:
    May be involved in cytoskeletal organization and tumorgenicity. Isoform 1 seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Isoform 3 may block ERK2 activation stimulated by ABL1. Isoform 3 may alter cell morphology and cell growth.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    1137
    Sequence:
    50:
    MTMTANKNSS | ITHGAGGTKA | PRGTLSRSQS | VSPPPVLSPP | RSPIYPLSDS | 
    100:
    ETSACRYPSH | SSSRVLLKDR | HPPAPSPQNP | QDPSPDTSPP | TCPFKTASFG | 
    150:
    YLDRSPSACK | RDAQKESVQG | AAQDVAGVAA | CLPLAQSTPF | PGPAAGPRGV | 
    200:
    LLTRTGTRAH | SLGIREKISA | WEGRREASPR | MSMCGEKREG | SGSEWAASEG | 
    250:
    CPSLGCPSVV | PSPCSSEKTF | DFKGLRRMSR | TFSECSYPET | EEEGEALPVR | 
    300:
    DSFYRLEKRL | GRSEPSAFLR | GHGSRKESSA | VLSRIQKIEQ | VLKEQPGRGL | 
    350:
    PQLPSSCYSV | DRGKRKTGTL | GSLEEPAGGA | SVSAGSRAVG | VAGVAGEAGP | 
    400:
    PPEREGSGST | KPGTPGNSPS | SQRLPSKSSL | DPAVNPVPKP | KRTFEYEADK | 
    450:
    NPKSKPSNGL | PPSPTPAAPP | PLPSTPAPPV | TRRPKKDMRG | HRKSQSRKSF | 
    500:
    EFEDASSLQS | LYPSSPTENG | TENQPKFGSK | STLEENAYED | IVGDLPKENP | 
    550:
    YEDVDLKSRR | AGRKSQQLSE | NSLDSLHRMW | SPQDRKYNSP | PTQLSLKPNS | 
    600:
    QSLRSGNWSE | RKSHRLPRLP | KRHSHDDMLL | LAQLSLPSSP | SSLNEDSLST | 
    650:
    TSELLSSRRA | RRIPKLVQRI | NSIYNAKRGK | KRLKKLSMSS | IETASLRDEN | 
    700:
    SESESDSDDR | FKAHTQRLVH | IQSMLKRAPS | YRTLELELLE | WQERELFEYF | 
    750:
    VVVSLKKKPS | RNTYLPEVSY | QFPKLDRPTK | QMREAEERLK | AIPQFCFPDA | 
    800:
    KDWLPVSEYS | SETFSFMLTG | EDGSRRFGYC | RRLLPSGKGP | RLPEVYCVIS | 
    850:
    RLGCFGLFSK | VLDEVERRRG | ISAALVYPFM | RSLMESPFPA | PGKTIKVKTF | 
    900:
    LPGAGNEVLE | LRRPMDSRLE | HVDFECLFTC | LSVRQLIRIF | ASLLLERRVI | 
    950:
    FVADKLSTLS | SCSHAVVALL | YPFSWQHTFI | PVLPASMIDI | VCCPTPFLVG | 
    1000:
    LLSSSLPKLK | ELPVEEALMV | NLGSDRFIRQ | MDDEDTLLPR | KLQAALEQAL | 
    1050:
    ERKNELISQD | SDSDSDDECN | TLNGLVSEVF | IRFFVETVGH | YSLFLTQSEK | 
    1100:
    GERAFQREAF | RKSVASKSIR | RFLEVFMESQ | MFAGFIQDRE | LRKCRAKGLF | 
    1137:
    EQRVEQYLEE | LPDTEQSGMN | KFLRGLGNKM | KFLHKKN
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    MIM:
    SMR:
    KEGG:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Suppression of tumorigenicity 5 protein
    ELISA Kit for Human Suppression of tumorigenicity 5 protein
    CLIA Kit for Human Suppression of tumorigenicity 5 protein
    CLIA Kit for Human Suppression of tumorigenicity 5 protein
    Polyclonal Antibody for Human Suppression of tumorigenicity 5 protein
    Polyclonal Antibody for Human Suppression of tumorigenicity 5 protein
    Monoclonal Antibody for Human Suppression of tumorigenicity 5 protein
    Monoclonal Antibody for Human Suppression of tumorigenicity 5 protein
    Protein for Human Suppression of tumorigenicity 5 protein
    Protein for Human Suppression of tumorigenicity 5 protein

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Differential expression of the human ST5 gene in HeLa-fibroblast hybrid cell lines mediated by YY1: evidence that YY1 plays a part in tumor suppression."
      Lichy J.H. , Majidi M. , Elbaum J. , Tsai M.M.
      Nucleic Acids Res.24:4700-4708(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3);VARIANT GLU-399
    2. 2.
      "Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7."
      Amid C. , Bahr A. , Mujica A. , Sampson N. , Bikar S.E. , Winterpacht A. , Zabel B. , Hankeln T. , Schmidt E.R.
      Cytogenet. Cell Genet.93:284-290(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT GLU-399
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)
      tissue: Brain.
      tissue: Spleen.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS ASN-316; THR-620 AND GLY-774
      tissue: Testis.
    7. 7.
      "Identification of a human chromosome 11 gene which is differentially regulated in tumorigenic and nontumorigenic somatic cell hybrids of HeLa cells."
      Lichy J.H. , Modi W.S. , Seuanez H.N. , Howley P.M.
      Cell Growth Differ.3:541-548(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 493-1137
    8. 8.
      "Activation of extracellular signal-regulated kinase 2 by a novel Abl-binding protein, ST5."
      Majidi M. , Hubbs A.E. , Lichy J.H.
      J. Biol. Chem.273:16608-16614(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ABL1
    9. 9.
      "Expression of an isoform of the novel signal transduction protein ST5 is linked to cell morphology."
      Hubbs A.E. , Majidi M. , Lichy J.H.
      Oncogene18:2519-2525(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-622;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    11. 11.
      "Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors."
      Yoshimura S. , Gerondopoulos A. , Linford A. , Rigden D.J. , Barr F.A.
      J. Cell Biol.191:367-381(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS GUANYL-NUCLEOTIDE EXCHANGE FACTOR
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