Gene name:
ST5 (DENND2B;HTS1) ;
Protein name:
Suppression of tumorigenicity 5 protein ;
Alternative:
HeLa tumor suppression 1 ;DENN domain-containing protein 2B ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Isoform 1 interacts with the SH3 domain of ABL1.
Function:
May be involved in cytoskeletal organization and tumorgenicity. Isoform 1 seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Isoform 3 may block ERK2 activation stimulated by ABL1. Isoform 3 may alter cell morphology and cell growth.
Subcellular Location:
N/A
Protein Attributes:
50:
MTMTANKNSS | ITHGAGGTKA | PRGTLSRSQS | VSPPPVLSPP | RSPIYPLSDS |
100:
ETSACRYPSH | SSSRVLLKDR | HPPAPSPQNP | QDPSPDTSPP | TCPFKTASFG |
150:
YLDRSPSACK | RDAQKESVQG | AAQDVAGVAA | CLPLAQSTPF | PGPAAGPRGV |
200:
LLTRTGTRAH | SLGIREKISA | WEGRREASPR | MSMCGEKREG | SGSEWAASEG |
250:
CPSLGCPSVV | PSPCSSEKTF | DFKGLRRMSR | TFSECSYPET | EEEGEALPVR |
300:
DSFYRLEKRL | GRSEPSAFLR | GHGSRKESSA | VLSRIQKIEQ | VLKEQPGRGL |
350:
PQLPSSCYSV | DRGKRKTGTL | GSLEEPAGGA | SVSAGSRAVG | VAGVAGEAGP |
400:
PPEREGSGST | KPGTPGNSPS | SQRLPSKSSL | DPAVNPVPKP | KRTFEYEADK |
450:
NPKSKPSNGL | PPSPTPAAPP | PLPSTPAPPV | TRRPKKDMRG | HRKSQSRKSF |
500:
EFEDASSLQS | LYPSSPTENG | TENQPKFGSK | STLEENAYED | IVGDLPKENP |
550:
YEDVDLKSRR | AGRKSQQLSE | NSLDSLHRMW | SPQDRKYNSP | PTQLSLKPNS |
600:
QSLRSGNWSE | RKSHRLPRLP | KRHSHDDMLL | LAQLSLPSSP | SSLNEDSLST |
650:
TSELLSSRRA | RRIPKLVQRI | NSIYNAKRGK | KRLKKLSMSS | IETASLRDEN |
700:
SESESDSDDR | FKAHTQRLVH | IQSMLKRAPS | YRTLELELLE | WQERELFEYF |
750:
VVVSLKKKPS | RNTYLPEVSY | QFPKLDRPTK | QMREAEERLK | AIPQFCFPDA |
800:
KDWLPVSEYS | SETFSFMLTG | EDGSRRFGYC | RRLLPSGKGP | RLPEVYCVIS |
850:
RLGCFGLFSK | VLDEVERRRG | ISAALVYPFM | RSLMESPFPA | PGKTIKVKTF |
900:
LPGAGNEVLE | LRRPMDSRLE | HVDFECLFTC | LSVRQLIRIF | ASLLLERRVI |
950:
FVADKLSTLS | SCSHAVVALL | YPFSWQHTFI | PVLPASMIDI | VCCPTPFLVG |
1000:
LLSSSLPKLK | ELPVEEALMV | NLGSDRFIRQ | MDDEDTLLPR | KLQAALEQAL |
1050:
ERKNELISQD | SDSDSDDECN | TLNGLVSEVF | IRFFVETVGH | YSLFLTQSEK |
1100:
GERAFQREAF | RKSVASKSIR | RFLEVFMESQ | MFAGFIQDRE | LRKCRAKGLF |
1137:
EQRVEQYLEE | LPDTEQSGMN | KFLRGLGNKM | KFLHKKN
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human Suppression of tumorigenicity 5 protein
ELISA Kit for Human Suppression of tumorigenicity 5 protein
CLIA Kit for Human Suppression of tumorigenicity 5 protein
CLIA Kit for Human Suppression of tumorigenicity 5 protein
Polyclonal Antibody for Human Suppression of tumorigenicity 5 protein
Polyclonal Antibody for Human Suppression of tumorigenicity 5 protein
Monoclonal Antibody for Human Suppression of tumorigenicity 5 protein
Monoclonal Antibody for Human Suppression of tumorigenicity 5 protein
Protein for Human Suppression of tumorigenicity 5 protein
Protein for Human Suppression of tumorigenicity 5 protein
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT GLU-399
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)
tissue :
Brain .
tissue :
Spleen .
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS ASN-316; THR-620 AND GLY-774
tissue :
Testis .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 493-1137
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH ABL1
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;TISSUE SPECIFICITY
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-622;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION AS GUANYL-NUCLEOTIDE EXCHANGE FACTOR