Signal transducer and activator of transcription 5A (Protein name
), STA5A_HUMAN from NCBI database.
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General Annotation
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Antigen Annotation
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Predicted Eptitope
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Vaild Sequence
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Gene name:
STAT5A(STAT5);
Protein name:
Signal transducer and activator of transcription 5A;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1 and SOCS7.
Function:
Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription.
Subcellular Location:
Cytoplasm
Nucleus
Translocated into the nucleus in response to phosphorylation.
Polyclonal Antibody for Human Signal transducer and activator of transcription 5A
Monoclonal Antibody for Human Signal transducer and activator of transcription 5A
Monoclonal Antibody for Human Signal transducer and activator of transcription 5A
Monoclonal Antibody for Human Signal transducer and activator of transcription 5A
Monoclonal Antibody for Human Signal transducer and activator of transcription 5A
Monoclonal Antibody for Human Signal transducer and activator of transcription 5A
Protein for Human Signal transducer and activator of transcription 5A
Protein for Human Signal transducer and activator of transcription 5A
Protein for Human Signal transducer and activator of transcription 5A
Protein for Human Signal transducer and activator of transcription 5A
Protein for Human Signal transducer and activator of transcription 5A
R&D Technical Data
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s
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s
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Precision
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Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.
Intra-Assay CV: ≤7.8%
Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.
Inter-Assay CV: ≤12.4%
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Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.
Intra-Assay CV: ≤3.9%
Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.
Inter-Assay CV: ≤7.7%
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Recovery
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Recovery was determined by spiking various levels of STA5A into serum and plasma .
Sample Type
Average(%)
Recovery Range(%)
Serum
97
91-103
Plasma
98
93-106
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Recovery was determined by spiking various levels of ACE into serum and plasma .
Sample Type
Average(%)
Recovery Range(%)
Serum
99
91-103
Plasma
98
93-106
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Linearity
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The linearity of the kit was assayed by testing samples spiked with appropriate concentration of STA5A and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.
Sample
1:2
1:4
1:8
1:16
serum(n=5)
91-105%
92-103%
95-100%
93-102%
EDTA plasma(n=5)
91-105%
94-102%
93-101%
95-101%
heparin plasma(n=5)
90-104%
95-100%
95-99%
92-104%
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.
Sample
1:2
1:4
1:8
1:16
serum(n=5)
92-105%
90-101%
95-105%
92-109%
EDTA plasma(n=5)
89-95%
93105%
89-94%
90-106%
heparin plasma(n=5)
93-104%
94-110%
101-111%
91-110%
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
3.
"Cloning and characterization of a variant of human stat5a, missing a portion of the n-terminal region, with dominant negative effects on the growth of breast cancer cells and [beta]-casein gene expression." Tan D.
,
Deng C.
,
Luben R.A.
,
Walker A.M.
Submitted (2006-04) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);ALTERNATIVE SPLICING
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
"A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: dephosphorylation and deactivation of signal transducer and activator of transcription 5a and 5b by TC-PTP in nucleus." Aoki N.
,
Matsuda T.
Mol. Endocrinol.16:58-69(2002)
[PubMed]
[Europe PMC]
[Abstract]
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Cited for: FUNCTION IN PROLACTIN SIGNALING PATHWAY;PHOSPHORYLATION;DEPHOSPHORYLATION BY PTPN2
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Cited for: INTERACTION WITH ERBB4;SUBCELLULAR LOCATION;FUNCTION
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-193;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: PHOSPHORYLATION AT TYR-694 IN RESPONSE TO KIT SIGNALING