NR5A1 ELISA Kit for Bovine(Bos taurus) | EIAab.comNR5A1 ELISA Kit for Bovine(Bos taurus)

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NR5A1 (Gene name),

Steroidogenic factor 1 (Protein name ), STF1_BOVIN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

NR5A1(AD4BP;FTZF1);

Protein name:

Steroidogenic factor 1(SF-1;STF-1);

Alternative:

Fushi tarazu factor homolog 1;Adrenal 4-binding protein;Steroid hormone receptor Ad4BP;Nuclear receptor subfamily 5 group A member 1;

Organism:

Bovine (Bos taurus).

General Annotation

Sub Unit:

Binds DNA as a monomer. Part of a complex consisting of SFPQ, NONO and NR5A1. Interacts with NR0B2. Interacts with DGKQ and CDK7. Binds to and activated by HIPK3.

Function:

Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

461

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

461:

LLIEMLQAKQ | T

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

bta:281948

UniGene:

Bt.7422

Pfam:

PF00104

STRING:

9913.ENSBTAP00000011869

String:

Q04752

SMR:

Q04752

Uniprot:

Q04752

FOR

ELISA Kit for Bovine SF-1

CLIA Kit for Bovine SF-1

Polyclonal Antibody for Bovine SF-1

Monoclonal Antibody for Bovine SF-1

Protein for Bovine SF-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Ad4BP regulating steroidogenic P-450 gene is a member of steroid hormone receptor superfamily."
Honda S. , Morohashi K. , Nomura M. , Takeya H. , Kitajima M. , Omura T.
J. Biol. Chem.268:7494-7502(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 120-180
tissue: Adrenal cortex.
2.

"Steroidogenic factor I, a key regulator of steroidogenic enzyme expression, is the mouse homolog of fushi tarazu-factor I."
Lala D.S. , Rice D.A. , Parker K.L.
Mol. Endocrinol.6:1249-1258(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 13-81

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