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Index > Protein center > Nr5a1(Gene name) > Mouse
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  • Nr5a1 (Gene name),
  • Steroidogenic factor 1 (Protein name ),  STF1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Nr5a1(Ftzf1);
    Protein name:
    Steroidogenic factor 1(SF-1;STF-1);
    Alternative:
    Embryonal LTR-binding protein(ELP);Adrenal 4-binding protein;Fushi tarazu factor homolog 1;Embryonal long terminal repeat-binding protein;Steroid hormone receptor Ad4BP;Nuclear receptor subfamily 5 group A member 1;Steroid hydroxylase positive regulator;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Binds DNA as a monomer (By similarity). Part of a complex consisting of SFPQ, NONO and NR5A1. Interacts with DGKQ and CDK7 (By similarity). Interacts with NR0B2, NCOA2 and PPARGC1A. Binds to and activated by HIPK3.
    Function:
    Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity (By similarity). Transcription repressor of the Moloney leukemia virus long terminal repeat in undifferentiated murine embryonal carcinoma cells. Binds phosphatidylcholine and phospholipids with a phosphatidylinositol (PI) headgroup, in particular phosphatidyl(3,4)bisphosphate, phosphatidyl(3,5)bisphosphate and phosphatidyl(3,4,5)triphosphate. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    462
    Sequence:
    50:
    MDYSYDEDLD | ELCPVCGDKV | SGYHYGLLTC | ESCKGFFKRT | VQNNKHYTCT | 
    100:
    ESQSCKIDKT | QRKRCPFCRF | QKCLTVGMRL | EAVRADRMRG | GRNKFGPMYK | 
    150:
    RDRALKQQKK | AQIRANGFKL | ETGPPMGVPP | PPPPPPDYML | PPSLHAPEPK | 
    200:
    ALVSGPPSGP | LGDFGAPSLP | MAVPGPHGPL | AGYLYPAFSN | RTIKSEYPEP | 
    250:
    YASPPQQPGP | PYSYPEPFSG | GPNVPELILQ | LLQLEPEEDQ | VRARIVGCLQ | 
    300:
    EPAKSRSDQP | APFSLLCRMA | DQTFISIVDW | ARRCMVFKEL | EVADQMTLLQ | 
    350:
    NCWSELLVLD | HIYRQVQYGK | EDSILLVTGQ | EVELSTVAVQ | AGSLLHSLVL | 
    400:
    RAQELVLQLH | ALQLDRQEFV | CLKFLILFSL | DVKFLNNHSL | VKDAQEKANA | 
    450:
    ALLDYTLCHY | PHCGDKFQQL | LLCLVEVRAL | SMQAKEYLYH | KHLGNEMPRN | 
    462:
    NLLIEMLQAK | QT
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    String:
    SMR:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse SF-1
    ELISA Kit for Mouse SF-1
    ELISA Kit for Mouse SF-1
    ELISA Kit for Mouse SF-1
    ELISA Kit for Mouse SF-1
    CLIA Kit for Mouse SF-1
    CLIA Kit for Mouse SF-1
    CLIA Kit for Mouse SF-1
    CLIA Kit for Mouse SF-1
    CLIA Kit for Mouse SF-1
    Polyclonal Antibody for Mouse SF-1
    Polyclonal Antibody for Mouse SF-1
    Polyclonal Antibody for Mouse SF-1
    Polyclonal Antibody for Mouse SF-1
    Polyclonal Antibody for Mouse SF-1
    Monoclonal Antibody for Mouse SF-1
    Monoclonal Antibody for Mouse SF-1
    Monoclonal Antibody for Mouse SF-1
    Monoclonal Antibody for Mouse SF-1
    Monoclonal Antibody for Mouse SF-1
    Protein for Mouse SF-1
    Protein for Mouse SF-1
    Protein for Mouse SF-1
    Protein for Mouse SF-1
    Protein for Mouse SF-1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Embryonal long terminal repeat-binding protein is a murine homolog of FTZ-F1, a member of the steroid receptor superfamily."
      Tsukiyama T. , Ueda H. , Hirose S. , Niwa O.
      Mol. Cell. Biol.12:1286-1291(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      strain: DBA/2J.
    2. 2.
      "Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression."
      Ikeda Y. , Lala D.S. , Luo X. , Kim E. , Moisan M.P. , Parker K.L.
      Mol. Endocrinol.7:852-860(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "A polymorphic form of steroidogenic factor-1 is associated with adrenocorticotropin resistance in y1 mouse adrenocortical tumor cell mutants."
      Frigeri C. , Tsao J. , Cordova M. , Schimmer B.P.
      Endocrinology143:4031-4037(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT SER-172
      strain: C57L/JxA/HeJF1.
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: C57BL/6J.
      tissue: Testis.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    7. 7.
      "The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction."
      Wilson T.E. , Fahrner T.J. , Milbrandt J.
      Mol. Cell. Biol.13:5794-5804(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
    8. 8.
      "Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and c-Jun phosphorylation."
      Lan H.-C. , Li H.-J. , Lin G. , Lai P.-Y. , Chung B.-C.
      Mol. Cell. Biol.27:2027-2036(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH HIPK3
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.2 ANGSTROMS) OF 219-462 IN COMPLEX WITH NR0B2 AND PHOSPHOLIPID;MUTAGENESIS OF ALA-270 AND ARG-314
    10. 10.
      "Crystallographic identification and functional characterization of phospholipids as ligands for the orphan nuclear receptor steroidogenic factor-1."
      Li Y. , Choi M. , Cavey G. , Daugherty J. , Suino K. , Kovach A. , Bingham N.C. , Kliewer S.A. , Xu H.E.
      Mol. Cell17:491-502(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 223-461 IN COMPLEX WITH NR0B2 AND PHOSPHOLIPID;MUTAGENESIS OF LEU-345; LEU-348; VAL-349; ALA-352; ALA-434 AND LYS-441
    11. 11.
      "Structure of SF-1 bound by different phospholipids: evidence for regulatory ligands."
      Sablin E.P. , Blind R.D. , Krylova I.N. , Ingraham J.G. , Cai F. , Williams J.D. , Fletterick R.J. , Ingraham H.A.
      Mol. Endocrinol.23:25-34(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 219-462 IN COMPLEX WITH LIPID AND PPARGC1A;INTERACTION WITH NCOA2 AND PPARGC1A;FUNCTION;MUTAGENESIS OF ALA-270 AND LEU-345;IDENTIFICATION BY MASS SPECTROMETRY
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