Nr5a1 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comNr5a1 ELISA Kit for Rat(Rattus norvegicus)

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Index > Protein center > Nr5a1(Gene name) > Rat

Nr5a1 (Gene name),

Steroidogenic factor 1 (Protein name ), STF1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Nr5a1(Ftzf1);

Protein name:

Steroidogenic factor 1(SF-1;STF-1);

Alternative:

Fushi tarazu factor homolog 1;Adrenal 4-binding protein;Steroid hormone receptor Ad4BP;Nuclear receptor subfamily 5 group A member 1;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Binds DNA as a monomer (By similarity). Part of a complex consisting of SFPQ, NONO and NR5A1. Interacts with NR0B2, NCOA2 and PPARGC1A. Interacts with DGKQ and CDK7. Binds to and activated by HIPK3.

Function:

Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Binds phosphatidylcholine and phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

462

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

462:

NLLIEMLQAK | QT

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

10116.ENSRNOP00000017651

Pfam:

PF00104

UniGene:

Rn.6586

String:

P50569

KEGG:

rno:83826

SMR:

P50569

UniGene:

Rn.229378

Uniprot:

P50569

FOR

ELISA Kit for Rat SF-1

CLIA Kit for Rat SF-1

Polyclonal Antibody for Rat SF-1

Monoclonal Antibody for Rat SF-1

Protein for Rat SF-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"An E box element is required for the expression of the ad4bp gene, a mammalian homologue of ftz-f1 gene, which is essential for adrenal and gonadal development."
Nomura M.M.N. , Smith J.
J. Biol. Chem.270:7453-7461(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain: Sprague-Dawley.
2.

"Steroidogenic factor 1, an orphan nuclear receptor, regulates the expression of the rat aromatase gene in gonadal tissues."
Lynch J.P. , Lala D.S. , Peluso J.J. , Luo W. , Parker K.L. , White B.A.
Mol. Endocrinol.7:776-786(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 20-293

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