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Index > Protein center > STK24(Gene name) > Human
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  • STK24 (Gene name),
  • Serine/threonine-protein kinase 24 (Protein name ),  STK24_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    STK24(MST3;STK3);
    Protein name:
    Serine/threonine-protein kinase 24;
    Alternative:
    STE20-like kinase MST3;Mammalian STE20-like protein kinase 3(MST-3);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer.
    Function:
    Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8-MAPK9), JUN and p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.
    Subcellular Location:
    Cytoplasm Nucleus Membrane The truncated form (MST3/N) translocates to the nucleus. Co-localizes with STK38L in the membrane.
    Protein Attributes:
    Sequence length:
    443
    Sequence:
    50:
    MDSRAQLWGL | ALNKRRATLP | HPGGSTNLKA | DPEELFTKLE | KIGKGSFGEV | 
    100:
    FKGIDNRTQK | VVAIKIIDLE | EAEDEIEDIQ | QEITVLSQCD | SPYVTKYYGS | 
    150:
    YLKDTKLWII | MEYLGGGSAL | DLLEPGPLDE | TQIATILREI | LKGLDYLHSE | 
    200:
    KKIHRDIKAA | NVLLSEHGEV | KLADFGVAGQ | LTDTQIKRNT | FVGTPFWMAP | 
    250:
    EVIKQSAYDS | KADIWSLGIT | AIELARGEPP | HSELHPMKVL | FLIPKNNPPT | 
    300:
    LEGNYSKPLK | EFVEACLNKE | PSFRPTAKEL | LKHKFILRNA | KKTSYLTELI | 
    350:
    DRYKRWKAEQ | SHDDSSSEDS | DAETDGQASG | GSDSGDWIFT | IREKDPKNLE | 
    400:
    NGALQPSDLD | RNKMKDIPKR | PFSQCLSTII | SPLFAELKEK | SQACGGNLGS | 
    443:
    IEELRGAIYL | AEEACPGISD | TMVAQLVQRL | QRYSLSGGGT | SSH
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    KEGG:
    String:
    Pfam:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Serine/threonine-protein kinase 24
    ELISA Kit for Human Serine/threonine-protein kinase 24
    ELISA Kit for Human Serine/threonine-protein kinase 24
    CLIA Kit for Human Serine/threonine-protein kinase 24
    CLIA Kit for Human Serine/threonine-protein kinase 24
    CLIA Kit for Human Serine/threonine-protein kinase 24
    Polyclonal Antibody for Human Serine/threonine-protein kinase 24
    Polyclonal Antibody for Human Serine/threonine-protein kinase 24
    Polyclonal Antibody for Human Serine/threonine-protein kinase 24
    Monoclonal Antibody for Human Serine/threonine-protein kinase 24
    Monoclonal Antibody for Human Serine/threonine-protein kinase 24
    Monoclonal Antibody for Human Serine/threonine-protein kinase 24
    Protein for Human Serine/threonine-protein kinase 24
    Protein for Human Serine/threonine-protein kinase 24
    Protein for Human Serine/threonine-protein kinase 24

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning and characterization of a human STE20-like protein kinase with unusual cofactor requirements."
      Schinkmann K. , Blenis J.
      J. Biol. Chem.272:28695-28703(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)
    2. 2.
      "Identification of a human brain-specific isoform of mammalian STE20-like kinase 3 that is regulated by cAMP-dependent protein kinase."
      Zhou T.-H. , Ling K. , Guo J. , Zhou H. , Wu Y.-L. , Jing Q. , Ma L. , Pei G.
      J. Biol. Chem.275:2513-2519(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B);PHOSPHORYLATION AT THR-18;MUTAGENESIS OF THR-18;VARIANT VAL-414
      tissue: Brain.
    3. 3.
      "The DNA sequence and analysis of human chromosome 13."
      Dunham A. , Matthews L.H. , Burton J. , Ashurst J.L. , Howe K.L. , Ashcroft K.J. , Beare D.M. , Burford D.C. , Hunt S.E. , Griffiths-Jones S. , Jones M.C. , Keenan S.J. , Oliver K. , Scott C.E. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews D.T. , more...
      Nature428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A)
      tissue: Skin.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-65 AND ASP-321
    7. 7.
      "Identification and characterization of the nuclear import and export signals of the mammalian Ste20-like protein kinase 3."
      Lee W.S. , Hsu C.Y. , Wang P.L. , Huang C.Y. , Chang C.H. , Yuan C.J.
      FEBS Lett.572:41-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;NUCLEAR LOCALIZATION SIGNAL;NUCLEAR EXPORT SIGNAL
    8. 8.
      "Zinc ion acts as a cofactor for serine/threonine kinase MST3 and has a distinct role in autophosphorylation of MST3."
      Lu T.J. , Huang C.Y. , Yuan C.J. , Lee Y.C. , Leu T.H. , Chang W.C. , Lu T.L. , Jeng W.Y. , Lai M.D.
      J. Inorg. Biochem.99:1306-1313(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: COFACTOR;BIOPHYSICOCHEMICAL PROPERTIES
    9. 9.
      "Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3."
      Stegert M.R. , Hergovich A. , Tamaskovic R. , Bichsel S.J. , Hemmings B.A.
      Mol. Cell. Biol.25:11019-11029(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    10. 10.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-320;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    11. 11.
      "Inhibition of cell migration by autophosphorylated mammalian sterile 20-like kinase 3 (MST3) involves paxillin and protein-tyrosine phosphatase-PEST."
      Lu T.J. , Lai W.Y. , Huang C.Y. , Hsieh W.J. , Yu J.S. , Hsieh Y.J. , Chang W.T. , Leu T.H. , Chang W.C. , Chuang W.J. , Tang M.J. , Chen T.Y. , Lu T.L. , Lai M.D.
      J. Biol. Chem.281:38405-38417(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT THR-190;MUTAGENESIS OF THR-190
    12. 12.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4 (ISOFORM A);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    13. 13.
      "Mammalian sterile 20-like kinase 3 (MST3) mediates oxidative-stress-induced cell death by modulating JNK activation."
      Chen C.B. , Ng J.K. , Choo P.H. , Wu W. , Porter A.G.
      Biosci. Rep.29:405-415(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT THR-190
    14. 14.
      "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein."
      Goudreault M. , D'Ambrosio L.M. , Kean M.J. , Mullin M.J. , Larsen B.G. , Sanchez A. , Chaudhry S. , Chen G.I. , Sicheri F. , Nesvizhskii A.I. , Aebersold R. , Raught B. , Gingras A.C.
      Mol. Cell. Proteomics8:157-171(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CTTNBP2NL
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2 (ISOFORM A);PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4 (ISOFORM A);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
    16. 16.
      "Mst3b, an Ste20-like kinase, regulates axon regeneration in mature CNS and PNS pathways."
      Lorber B. , Howe M.L. , Benowitz L.I. , Irwin N.
      Nat. Neurosci.12:1407-1414(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    17. 17.
      "Mammalian Ste20-like protein kinase 3 induces a caspase-independent apoptotic pathway."
      Lin C.Y. , Wu H.Y. , Wang P.L. , Yuan C.J.
      Int. J. Biochem. Cell Biol.42:98-105(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    18. 18.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2 (ISOFORM A);PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4 (ISOFORM A);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    19. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    20. 20.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2 (ISOFORM A);PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4 (ISOFORM A);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    21. 21.
      "Structures of human MST3 kinase in complex with adenine, ADP and Mn2+."
      Ko T.P. , Jeng W.Y. , Liu C.I. , Lai M.D. , Wu C.L. , Chang W.J. , Shr H.L. , Lu T.J. , Wang A.H.
      Acta Crystallogr. D66:145-154(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 27-315 IN COMPLEX WITH ADENINE; ADP AND MANGANESE IONS;SUBUNIT;PHOSPHORYLATION AT THR-190
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