Gene name:
STK24 (MST3;STK3) ;
Protein name:
Serine/threonine-protein kinase 24 ;
Alternative:
STE20-like kinase MST3 ;Mammalian STE20-like protein kinase 3 (MST-3) ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8-MAPK9), JUN and p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.
Subcellular Location:
Cytoplasm
Nucleus
Membrane
The truncated form (MST3/N) translocates to the nucleus. Co-localizes with STK38L in the membrane.
Protein Attributes:
50:
MDSRAQLWGL | ALNKRRATLP | HPGGSTNLKA | DPEELFTKLE | KIGKGSFGEV |
100:
FKGIDNRTQK | VVAIKIIDLE | EAEDEIEDIQ | QEITVLSQCD | SPYVTKYYGS |
150:
YLKDTKLWII | MEYLGGGSAL | DLLEPGPLDE | TQIATILREI | LKGLDYLHSE |
200:
KKIHRDIKAA | NVLLSEHGEV | KLADFGVAGQ | LTDTQIKRNT | FVGTPFWMAP |
250:
EVIKQSAYDS | KADIWSLGIT | AIELARGEPP | HSELHPMKVL | FLIPKNNPPT |
300:
LEGNYSKPLK | EFVEACLNKE | PSFRPTAKEL | LKHKFILRNA | KKTSYLTELI |
350:
DRYKRWKAEQ | SHDDSSSEDS | DAETDGQASG | GSDSGDWIFT | IREKDPKNLE |
400:
NGALQPSDLD | RNKMKDIPKR | PFSQCLSTII | SPLFAELKEK | SQACGGNLGS |
443:
IEELRGAIYL | AEEACPGISD | TMVAQLVQRL | QRYSLSGGGT | SSH
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
ELISA Kit for Human Serine/threonine-protein kinase 24
ELISA Kit for Human Serine/threonine-protein kinase 24
ELISA Kit for Human Serine/threonine-protein kinase 24
CLIA Kit for Human Serine/threonine-protein kinase 24
CLIA Kit for Human Serine/threonine-protein kinase 24
CLIA Kit for Human Serine/threonine-protein kinase 24
Polyclonal Antibody for Human Serine/threonine-protein kinase 24
Polyclonal Antibody for Human Serine/threonine-protein kinase 24
Polyclonal Antibody for Human Serine/threonine-protein kinase 24
Monoclonal Antibody for Human Serine/threonine-protein kinase 24
Monoclonal Antibody for Human Serine/threonine-protein kinase 24
Monoclonal Antibody for Human Serine/threonine-protein kinase 24
Protein for Human Serine/threonine-protein kinase 24
Protein for Human Serine/threonine-protein kinase 24
Protein for Human Serine/threonine-protein kinase 24
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B);PHOSPHORYLATION AT THR-18;MUTAGENESIS OF THR-18;VARIANT VAL-414
tissue :
Brain .
3.
"The DNA sequence and analysis of human chromosome 13."
Dunham A.
,
Matthews L.H.
,
Burton J.
,
Ashurst J.L.
,
Howe K.L.
,
Ashcroft K.J.
,
Beare D.M.
,
Burford D.C.
,
Hunt S.E.
,
Griffiths-Jones S.
,
Jones M.C.
,
Keenan S.J.
,
Oliver K.
,
Scott C.E.
,
Ainscough R.
,
Almeida J.P.
,
Ambrose K.D.
,
Andrews D.T.
,
Ashwell R.I.S.
,
Babbage A.K.
,
Bagguley C.L.
,
Bailey J.
,
Bannerjee R.
,
Barlow K.F.
,
Bates K.
,
Beasley H.
,
Bird C.P.
,
Bray-Allen S.
,
Brown A.J.
,
Brown J.Y.
,
Burrill W.
,
Carder C.
,
Carter N.P.
,
Chapman J.C.
,
Clamp M.E.
,
Clark S.Y.
,
Clarke G.
,
Clee C.M.
,
Clegg S.C.
,
Cobley V.
,
Collins J.E.
,
Corby N.
,
Coville G.J.
,
Deloukas P.
,
Dhami P.
,
Dunham I.
,
Dunn M.
,
Earthrowl M.E.
,
Ellington A.G.
,
Faulkner L.
,
Frankish A.G.
,
Frankland J.
,
French L.
,
Garner P.
,
Garnett J.
,
Gilbert J.G.R.
,
Gilson C.J.
,
Ghori J.
,
Grafham D.V.
,
Gribble S.M.
,
Griffiths C.
,
Hall R.E.
,
Hammond S.
,
Harley J.L.
,
Hart E.A.
,
Heath P.D.
,
Howden P.J.
,
Huckle E.J.
,
Hunt P.J.
,
Hunt A.R.
,
Johnson C.
,
Johnson D.
,
Kay M.
,
Kimberley A.M.
,
King A.
,
Laird G.K.
,
Langford C.J.
,
Lawlor S.
,
Leongamornlert D.A.
,
Lloyd D.M.
,
Lloyd C.
,
Loveland J.E.
,
Lovell J.
,
Martin S.
,
Mashreghi-Mohammadi M.
,
McLaren S.J.
,
McMurray A.
,
Milne S.
,
Moore M.J.F.
,
Nickerson T.
,
Palmer S.A.
,
Pearce A.V.
,
Peck A.I.
,
Pelan S.
,
Phillimore B.
,
Porter K.M.
,
Rice C.M.
,
Searle S.
,
Sehra H.K.
,
Shownkeen R.
,
Skuce C.D.
,
Smith M.
,
Steward C.A.
,
Sycamore N.
,
Tester J.
,
Thomas D.W.
,
Tracey A.
,
Tromans A.
,
Tubby B.
,
Wall M.
,
Wallis J.M.
,
West A.P.
,
Whitehead S.L.
,
Willey D.L.
,
Wilming L.
,
Wray P.W.
,
Wright M.W.
,
Young L.
,
Coulson A.
,
Durbin R.M.
,
Hubbard T.
,
Sulston J.E.
,
Beck S.
,
Bentley D.R.
,
Rogers J.
,
Ross M.T.
more...
Nature428:522-528(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
Mural R.J.
,
Istrail S.
,
Sutton G.G.
,
Florea L.
,
Halpern A.L.
,
Mobarry C.M.
,
Lippert R.
,
Walenz B.
,
Shatkay H.
,
Dew I.
,
Miller J.R.
,
Flanigan M.J.
,
Edwards N.J.
,
Bolanos R.
,
Fasulo D.
,
Halldorsson B.V.
,
Hannenhalli S.
,
Turner R.
,
Yooseph S.
,
Lu F.
,
Nusskern D.R.
,
Shue B.C.
,
Zheng X.H.
,
Zhong F.
,
Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A)
tissue :
Skin .
6.
"Caspase activation of mammalian sterile 20-like kinase 3 (Mst3)."
Huang C.Y.
,
Wu Y.M.
,
Hsu C.Y.
,
Lee W.S.
,
Lai M.D.
,
Lu T.J.
,
Huang C.L.
,
Leu T.H.
,
Shih H.M.
,
Fang H.I.
,
Robinson D.R.
,
Kung H.J.
,
Yuan C.J.
J. Biol. Chem.277:34367-34374(2002)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEOLYTIC PROCESSING;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-65 AND ASP-321
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;NUCLEAR LOCALIZATION SIGNAL;NUCLEAR EXPORT SIGNAL
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : COFACTOR;BIOPHYSICOCHEMICAL PROPERTIES
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-320;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
11.
"Inhibition of cell migration by autophosphorylated mammalian sterile 20-like kinase 3 (MST3) involves paxillin and protein-tyrosine phosphatase-PEST."
Lu T.J.
,
Lai W.Y.
,
Huang C.Y.
,
Hsieh W.J.
,
Yu J.S.
,
Hsieh Y.J.
,
Chang W.T.
,
Leu T.H.
,
Chang W.C.
,
Chuang W.J.
,
Tang M.J.
,
Chen T.Y.
,
Lu T.L.
,
Lai M.D.
J. Biol. Chem.281:38405-38417(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;PHOSPHORYLATION AT THR-190;MUTAGENESIS OF THR-190
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4 (ISOFORM A);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;PHOSPHORYLATION AT THR-190
14.
"A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein."
Goudreault M.
,
D'Ambrosio L.M.
,
Kean M.J.
,
Mullin M.J.
,
Larsen B.G.
,
Sanchez A.
,
Chaudhry S.
,
Chen G.I.
,
Sicheri F.
,
Nesvizhskii A.I.
,
Aebersold R.
,
Raught B.
,
Gingras A.C.
Mol. Cell. Proteomics8:157-171(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CTTNBP2NL
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2 (ISOFORM A);PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4 (ISOFORM A);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
18.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V.
,
Vermeulen M.
,
Santamaria A.
,
Kumar C.
,
Miller M.L.
,
Jensen L.J.
,
Gnad F.
,
Cox J.
,
Jensen T.S.
,
Nigg E.A.
,
Brunak S.
,
Mann M.
Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2 (ISOFORM A);PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4 (ISOFORM A);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2 (ISOFORM A);PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4 (ISOFORM A);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 27-315 IN COMPLEX WITH ADENINE; ADP AND MANGANESE IONS;SUBUNIT;PHOSPHORYLATION AT THR-190
22.
"Patterns of somatic mutation in human cancer genomes."
Greenman C.
,
Stephens P.
,
Smith R.
,
Dalgliesh G.L.
,
Hunter C.
,
Bignell G.
,
Davies H.
,
Teague J.
,
Butler A.
,
Stevens C.
,
Edkins S.
,
O'Meara S.
,
Vastrik I.
,
Schmidt E.E.
,
Avis T.
,
Barthorpe S.
,
Bhamra G.
,
Buck G.
,
Choudhury B.
,
Clements J.
,
Cole J.
,
Dicks E.
,
Forbes S.
,
Gray K.
,
Halliday K.
,
Harrison R.
,
Hills K.
,
Hinton J.
,
Jenkinson A.
,
Jones D.
,
Menzies A.
,
Mironenko T.
,
Perry J.
,
Raine K.
,
Richardson D.
,
Shepherd R.
,
Small A.
,
Tofts C.
,
Varian J.
,
Webb T.
,
West S.
,
Widaa S.
,
Yates A.
,
Cahill D.P.
,
Louis D.N.
,
Goldstraw P.
,
Nicholson A.G.
,
Brasseur F.
,
Looijenga L.
,
Weber B.L.
,
Chiew Y.-E.
,
DeFazio A.
,
Greaves M.F.
,
Green A.R.
,
Campbell P.
,
Birney E.
,
Easton D.F.
,
Chenevix-Trench G.
,
Tan M.-H.
,
Khoo S.K.
,
Teh B.T.
,
Yuen S.T.
,
Leung S.Y.
,
Wooster R.
,
Futreal P.A.
,
Stratton M.R.
more...
Nature446:153-158(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS [LARGE SCALE ANALYSIS] VAL-414 AND ILE-426