Stk24 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comStk24 ELISA Kit for Rat(Rattus norvegicus)

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Stk24 (Gene name),

Serine/threonine-protein kinase 24 (Protein name ), STK24_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Stk24(Mst3;Stk3);

Protein name:

Serine/threonine-protein kinase 24;

Alternative:

STE20-like kinase MST3;Mammalian STE20-like protein kinase 3(MST-3;MST3b);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Monomer.

Function:

Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8-MAPK9), JUN and p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12 (By similarity). Acts as a key regulator of axon regeneration in the adult optic nerve and radial nerve.

Subcellular Location:

Cytoplasm Nucleus Membrane The truncated form (MST3/N) translocates to the nucleus. Co-localizes with STK38L in the membrane.

Protein Attributes:

Sequence length:

431

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

431:

EACPGISDTM | VAQLVQRLQR | YSLSGGGASA | H

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

10116.ENSRNOP00000031981

SMR:

B0LT89

Pfam:

PF00069

UniGene:

Rn.105397

String:

B0LT89

KEGG:

rno:361092

Uniprot:

B0LT89

FOR

ELISA Kit for Rat Serine/threonine-protein kinase 24

CLIA Kit for Rat Serine/threonine-protein kinase 24

Polyclonal Antibody for Rat Serine/threonine-protein kinase 24

Monoclonal Antibody for Rat Serine/threonine-protein kinase 24

Protein for Rat Serine/threonine-protein kinase 24

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"MST3 expression in rat cardiac myocytes."
Fuller S.J. , Pikkarainen S.A. , Clerk A. , Sugden P.H.
Submitted (2008-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: Sprague-Dawley.
2.

"Mst3b, an Ste20-like kinase, regulates axon regeneration in mature CNS and PNS pathways."
Lorber B. , Howe M.L. , Benowitz L.I. , Irwin N.
Nat. Neurosci.12:1407-1414(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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