Gene name:
STK4 (RCJMB04_17i1) ;
Protein name:
Serine/threonine-protein kinase 4 ;
Alternative:
Organism:
Chicken (Gallus gallus).
General Annotation
Sub Unit:
Homodimer; mediated via the coiled-coil region.
Function:
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation.
Subcellular Location:
Cytoplasm
Nucleus
The caspase-cleaved form cycles between nucleus and cytoplasm.
Protein Attributes:
50:
METVQLRNPR | RQLKKLDEDS | LTKQPEEVFD | VLEKLGEGSY | GSVFKAIHKE |
100:
TGQVVAIKQV | PVESDLQEII | KEISIMQQCD | SPHVVKYYGS | YFKNTDLWIV |
150:
MEYCGAGSVS | DIIRLRNKTL | TEEEIATIVQ | STLKGLEYLH | FMRKIHRDIK |
200:
AGNILLNTEG | HAKLADFGVA | GQLTDTMAKR | NTVIGTPFWM | APGVIQEIGY |
250:
NCVADIWSLG | ITAIEMAEGK | PPYADIHPMR | AIFMIPTNPP | PTFRKPELWS |
300:
DAFTDFVKQC | LVKSPEQRAT | AIQLLQHPFV | KSAKGASILR | DLINEAMDIK |
350:
LKRQEAQQRE | LDQEDEENSE | EDETDSGTMV | RASGDETGTI | RVVNTMSDGA |
400:
NTMIEHDGTL | ESQLGTMVIN | TEDEEEEGTM | KRRDETMQPA | RPSFLEYFEQ |
450:
KAKENQVNSF | GKNVSGQTKN | SSDWKVPQDG | DYEFLKTWSV | DELQRRLSAL |
486:
DPMMEQEIEE | IRQKYQSKRQ | PILDAIEAKK | RRQQNF
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Bovine
Chicken
Mouse
ELISA Kit for Chicken Serine/threonine-protein kinase 4
ELISA Kit for Chicken Serine/threonine-protein kinase 4
ELISA Kit for Chicken Serine/threonine-protein kinase 4
ELISA Kit for Chicken Serine/threonine-protein kinase 4
CLIA Kit for Chicken Serine/threonine-protein kinase 4
CLIA Kit for Chicken Serine/threonine-protein kinase 4
CLIA Kit for Chicken Serine/threonine-protein kinase 4
CLIA Kit for Chicken Serine/threonine-protein kinase 4
Polyclonal Antibody for Chicken Serine/threonine-protein kinase 4
Polyclonal Antibody for Chicken Serine/threonine-protein kinase 4
Polyclonal Antibody for Chicken Serine/threonine-protein kinase 4
Polyclonal Antibody for Chicken Serine/threonine-protein kinase 4
Monoclonal Antibody for Chicken Serine/threonine-protein kinase 4
Monoclonal Antibody for Chicken Serine/threonine-protein kinase 4
Monoclonal Antibody for Chicken Serine/threonine-protein kinase 4
Monoclonal Antibody for Chicken Serine/threonine-protein kinase 4
Protein for Chicken Serine/threonine-protein kinase 4
Protein for Chicken Serine/threonine-protein kinase 4
Protein for Chicken Serine/threonine-protein kinase 4
Protein for Chicken Serine/threonine-protein kinase 4
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis."
Caldwell R.B.
,
Kierzek A.M.
,
Arakawa H.
,
Bezzubov Y.
,
Zaim J.
,
Fiedler P.
,
Kutter S.
,
Blagodatski A.
,
Kostovska D.
,
Koter M.
,
Plachy J.
,
Carninci P.
,
Hayashizaki Y.
,
Buerstedde J.-M.
Genome Biol.6:R6.1-R6.9(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
CB .
tissue :
Bursa of Fabricius .