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Index > Protein center > STK4(Gene name) > Chicken
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  • STK4 (Gene name),
  • Serine/threonine-protein kinase 4 (Protein name ),  STK4_CHICK from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    STK4(RCJMB04_17i1);
    Protein name:
    Serine/threonine-protein kinase 4;
    Alternative:

    Organism:
    Chicken (Gallus gallus). 
    General Annotation
    Sub Unit:
    Homodimer; mediated via the coiled-coil region.
    Function:
    Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation.
    Subcellular Location:
    Cytoplasm Nucleus The caspase-cleaved form cycles between nucleus and cytoplasm.
    Protein Attributes:
    Sequence length:
    486
    Sequence:
    50:
    METVQLRNPR | RQLKKLDEDS | LTKQPEEVFD | VLEKLGEGSY | GSVFKAIHKE | 
    100:
    TGQVVAIKQV | PVESDLQEII | KEISIMQQCD | SPHVVKYYGS | YFKNTDLWIV | 
    150:
    MEYCGAGSVS | DIIRLRNKTL | TEEEIATIVQ | STLKGLEYLH | FMRKIHRDIK | 
    200:
    AGNILLNTEG | HAKLADFGVA | GQLTDTMAKR | NTVIGTPFWM | APGVIQEIGY | 
    250:
    NCVADIWSLG | ITAIEMAEGK | PPYADIHPMR | AIFMIPTNPP | PTFRKPELWS | 
    300:
    DAFTDFVKQC | LVKSPEQRAT | AIQLLQHPFV | KSAKGASILR | DLINEAMDIK | 
    350:
    LKRQEAQQRE | LDQEDEENSE | EDETDSGTMV | RASGDETGTI | RVVNTMSDGA | 
    400:
    NTMIEHDGTL | ESQLGTMVIN | TEDEEEEGTM | KRRDETMQPA | RPSFLEYFEQ | 
    450:
    KAKENQVNSF | GKNVSGQTKN | SSDWKVPQDG | DYEFLKTWSV | DELQRRLSAL | 
    486:
    DPMMEQEIEE | IRQKYQSKRQ | PILDAIEAKK | RRQQNF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Chicken Serine/threonine-protein kinase 4
    Cat.:
    E13100h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Chicken Serine/threonine-protein kinase 4
    Cat.:
    E13100b
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Chicken Serine/threonine-protein kinase 4
    Cat.:
    E13100c
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Chicken Serine/threonine-protein kinase 4
    Cat.:
    E13100m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Chicken Serine/threonine-protein kinase 4
    Cat.:
    U13100m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Chicken Serine/threonine-protein kinase 4
    Cat.:
    U13100h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Chicken Serine/threonine-protein kinase 4
    Cat.:
    U13100c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Chicken Serine/threonine-protein kinase 4
    Cat.:
    U13100b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Chicken Serine/threonine-protein kinase 4
    Polyclonal Antibody for Chicken Serine/threonine-protein kinase 4
    Polyclonal Antibody for Chicken Serine/threonine-protein kinase 4
    Cat.:
    P13100Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Chicken Serine/threonine-protein kinase 4
    Cat.:
    P13100Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Chicken Serine/threonine-protein kinase 4
    Monoclonal Antibody for Chicken Serine/threonine-protein kinase 4
    Monoclonal Antibody for Chicken Serine/threonine-protein kinase 4
    Monoclonal Antibody for Chicken Serine/threonine-protein kinase 4
    Protein for Chicken Serine/threonine-protein kinase 4
    Protein for Chicken Serine/threonine-protein kinase 4
    Protein for Chicken Serine/threonine-protein kinase 4
    Protein for Chicken Serine/threonine-protein kinase 4

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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: CB.
      tissue: Bursa of Fabricius.
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