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Index > Protein center > Stk4(Gene name) > Mouse
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  • Stk4 (Gene name),
  • Serine/threonine-protein kinase 4 (Protein name ),  STK4_MOUSE from NCBI database.
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  • Gene name:
    Stk4(Mst1);
    Protein name:
    Serine/threonine-protein kinase 4;
    Alternative:
    STE20-like kinase MST1;Mammalian STE20-like protein kinase 1(MST-1);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homodimer; mediated via the coiled-coil region. Interacts with NORE1, which inhibits autoactivation. Interacts with and stabilizes SAV1. Interacts with RASSF1, which leads to enzyme activation. Interacts with FOXO3.
    Function:
    Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. MST1/MST2 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation.
    Subcellular Location:
    Cytoplasm Nucleus The caspase-cleaved form cycles between nucleus and cytoplasm.
    Protein Attributes:
    Sequence length:
    487
    Sequence:
    50:
    METVQLRNPP | RRQLKKLDED | SLTKQPEEVF | DVLEKLGEGS | YGSVYKAIHK | 
    100:
    ETGQIVAIKQ | VPVESDLQEI | IKEISIMQQC | DSPHVVKYYG | SYFKNTDLWI | 
    150:
    VMEYCGAGSV | SDIIRLRNKT | LTEDEIATIL | QSTLKGLEYL | HFMRKIHRDI | 
    200:
    KAGNILLNTE | GHAKLADFGV | AGQLTDTMAK | RNTVIGTPFW | MAPEVIQEIG | 
    250:
    YNCVADIWSL | GITAIEMAEG | KPPYADIHPM | RAIFMIPTNP | PPTFRKPELW | 
    300:
    SDNFMDFVKQ | CLVKSPEQRA | TATQLLQHPF | VKSAKGVSIL | RDLINEAMDV | 
    350:
    KLKRQEAQQR | EVDQDDEENS | EEDEMDSGTM | VRAAGDEMGT | VRVASTMSGG | 
    400:
    ANTMIEHGDT | LPSQLGTMVI | NTEDEEEEGT | MKRRDETMQP | AKPSFLEYFE | 
    450:
    QKEKENQINS | FGKNVSGSLK | NSSDWKIPQD | GDYEFLKSWT | VEDLQKRLLA | 
    487:
    LDPMMEQEME | EIRQKYRSKR | QPILDAIEAK | KRRQQNF
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    KEGG:
    String:
    SMR:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Serine/threonine-protein kinase 4
    Cat.:
    E13100h
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    Packing:
    96T
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    ELISA Kit for Mouse Serine/threonine-protein kinase 4
    Cat.:
    E13100b
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse Serine/threonine-protein kinase 4
    Cat.:
    E13100c
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse Serine/threonine-protein kinase 4
    Cat.:
    E13100m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Serine/threonine-protein kinase 4
    Cat.:
    U13100m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Serine/threonine-protein kinase 4
    Cat.:
    U13100h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Serine/threonine-protein kinase 4
    Cat.:
    U13100c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Serine/threonine-protein kinase 4
    Cat.:
    U13100b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Serine/threonine-protein kinase 4
    Polyclonal Antibody for Mouse Serine/threonine-protein kinase 4
    Polyclonal Antibody for Mouse Serine/threonine-protein kinase 4
    Cat.:
    P13100Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Serine/threonine-protein kinase 4
    Cat.:
    P13100Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Serine/threonine-protein kinase 4
    Monoclonal Antibody for Mouse Serine/threonine-protein kinase 4
    Monoclonal Antibody for Mouse Serine/threonine-protein kinase 4
    Monoclonal Antibody for Mouse Serine/threonine-protein kinase 4
    Protein for Mouse Serine/threonine-protein kinase 4
    Protein for Mouse Serine/threonine-protein kinase 4
    Protein for Mouse Serine/threonine-protein kinase 4
    Protein for Mouse Serine/threonine-protein kinase 4

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    References
    1. 1.
      "MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation."
      Lee K.-K. , Ohyama T. , Yajima N. , Tsubuki S. , Yonehara S.
      J. Biol. Chem.276:19276-19285(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEOLYTIC PROCESSING
      strain: BALB/c.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Skin.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
      tissue: Brain.
    4. 4.
      "Phosphoproteomic analysis of the developing mouse brain."
      Ballif B.A. , Villen J. , Beausoleil S.A. , Schwartz D. , Gygi S.P.
      Mol. Cell. Proteomics3:1093-1101(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-320;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic brain.
    5. 5.
      "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
      Cao L. , Yu K. , Banh C. , Nguyen V. , Ritz A. , Raphael B.J. , Kawakami Y. , Kawakami T. , Salomon A.R.
      J. Immunol.179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-433;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Mast cell.
    6. 6.
      "Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver."
      Lu L. , Li Y. , Kim S.M. , Bossuyt W. , Liu P. , Qiu Q. , Wang Y. , Halder G. , Finegold M.J. , Lee J.S. , Johnson R.L.
      Proc. Natl. Acad. Sci. U.S.A.107:1437-1442(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
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