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Index > Protein center > STOML2(Gene name) > Human
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  • STOML2 (Gene name),
  • Stomatin-like protein 2 (Protein name ),  STML2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    STOML2(HSPC108;SLP2);
    Protein name:
    Stomatin-like protein 2(SLP-2);
    Alternative:
    Paraprotein target 7(Paratarg-7);EPB72-like protein 2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with CACNA2D2.
    Function:
    N/A
    Subcellular Location:
    Membrane Peripheral membrane protein Cytoplasm Cytoplasm cytoskeleton Associated with the cytoskeleton.
    Protein Attributes:
    Sequence length:
    356
    Sequence:
    50:
    MLARAARGTG | ALLLRGSLLA | SGRAPRRASS | GLPRNTVVLF | VPQQEAWVVE | 
    100:
    RMGRFHRILE | PGLNILIPVL | DRIRYVQSLK | EIVINVPEQS | AVTLDNVTLQ | 
    150:
    IDGVLYLRIM | DPYKASYGVE | DPEYAVTQLA | QTTMRSELGK | LSLDKVFRER | 
    200:
    ESLNASIVDA | INQAADCWGI | RCLRYEIKDI | HVPPRVKESM | QMQVEAERRK | 
    250:
    RATVLESEGT | RESAINVAEG | KKQAQILASE | AEKAEQINQA | AGEASAVLAK | 
    300:
    AKAKAEAIRI | LAAALTQHNG | DAAASLTVAE | QYVSAFSKLA | KDSNTILLPS | 
    350:
    NPGDVTSMVA | QAMGVYGALT | KAPVPGTPDS | LSSGSSRDVQ | GTDASLDEEL | 
    356:
    DRVKMS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    MIM:
    String:
    SMR:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human SLP-2
    ELISA Kit for Human SLP-2
    ELISA Kit for Human SLP-2
    ELISA Kit for Human SLP-2
    CLIA Kit for Human SLP-2
    CLIA Kit for Human SLP-2
    CLIA Kit for Human SLP-2
    CLIA Kit for Human SLP-2
    Polyclonal Antibody for Human SLP-2
    Polyclonal Antibody for Human SLP-2
    Polyclonal Antibody for Human SLP-2
    Polyclonal Antibody for Human SLP-2
    Monoclonal Antibody for Human SLP-2
    Monoclonal Antibody for Human SLP-2
    Monoclonal Antibody for Human SLP-2
    Monoclonal Antibody for Human SLP-2
    Protein for Human SLP-2
    Protein for Human SLP-2
    Protein for Human SLP-2
    Protein for Human SLP-2

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    Linearity
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    References
    1. 1.
      "Identification and characterization of human SLP-2, a novel homologue of stomatin (band 7.2b) present in erythrocytes and other tissues."
      Wang Y. , Morrow J.S.
      J. Biol. Chem.275:8062-8071(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);SUBCELLULAR LOCATION;TISSUE SPECIFICITY
      tissue: Heart muscle.
    2. 2.
      "A novel member of the stomatin/EPB72/mec-2 family, stomatin-like 2 (STOML2), is ubiquitously expressed and localizes to HSA chromosome 9p13.1."
      Owczarek C.M. , Treutlein H.R. , Portbury K.J. , Gulluyan L.M. , Kola I. , Hertzog P.J.
      Cytogenet. Cell Genet.92:196-203(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1);TISSUE SPECIFICITY
      tissue: Fetal brain.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Trachea.
    4. 4.
      Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    5. 5.
      "DNA sequence and analysis of human chromosome 9."
      Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
      Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT PRO-129
      tissue: Lung.
      tissue: Pancreas.
      tissue: Skin.
    8. 8.
      "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H. , Ye M. , Wu X.-Y. , Ren S.-X. , Zhao M. , Zhao C.-J. , Fu G. , Shen Y. , Fan H.-Y. , Lu G. , Zhong M. , Xu X.-R. , Han Z.-G. , Zhang J.-W. , Tao J. , Huang Q.-H. , Zhou J. , Hu G.-X. , more...
      Genome Res.10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-356 (ISOFORM 1)
      tissue: Umbilical cord blood.
    9. 9.
      Bienvenut W.V.
      Submitted (2005-06) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 188-197; 201-211 AND 234-250;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: B-cell lymphoma.
    10. 10.
      "Mass spectrometrical verification of stomatin-like protein 2 (SLP-2) primary structure."
      John J.P. , Anrather D. , Pollak A. , Lubec G.
      Proteins64:543-551(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;IDENTIFICATION BY MASS SPECTROMETRY
    11. 11.
      "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
      Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-124;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 12.
      "Identification of a novel mitochondrial complex containing mitofusin 2 and stomatin-like protein 2."
      Hajek P. , Chomyn A. , Attardi G.
      J. Biol. Chem.282:5670-5681(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION BY MASS SPECTROMETRY;INTERACTION WITH MFN2;SUBCELLULAR LOCATION
    13. 13.
      "SLP-2 interacts with prohibitins in the mitochondrial inner membrane and contributes to their stability."
      Da Cruz S. , Parone P.A. , Gonzalo P. , Bienvenut W.V. , Tondera D. , Jourdain A. , Quadroni M. , Martinou J.C.
      Biochim. Biophys. Acta1783:904-911(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH PHB AND PHB2
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN T-CELL ACTIVATION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INDUCTION
    15. 15.
      "Downregulation of a mitochondria associated protein SLP-2 inhibits tumor cell motility, proliferation and enhances cell sensitivity to chemotherapeutic reagents."
      Wang Y. , Cao W. , Yu Z. , Liu Z.
      Cancer Biol. Ther.8:1651-1658(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    16. 16.
      "A frequent target of paraproteins in the sera of patients with multiple myeloma and MGUS."
      Preuss K.D. , Pfreundschuh M. , Ahlgrimm M. , Fadle N. , Regitz E. , Murawski N. , Grass S.
      Int. J. Cancer125:656-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION AS A COMMON ANTIGEN IN B-CELL NEOPLASMS
    17. 17.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-145 AND LYS-233;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    18. 18.
      "SLP-2 negatively modulates mitochondrial sodium-calcium exchange."
      Da Cruz S. , De Marchi U. , Frieden M. , Parone P.A. , Martinou J.C. , Demaurex N.
      Cell Calcium47:11-18(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CALCIUM HOMEOSTASIS
    19. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    20. 20.
      "Hyperphosphorylation of autoantigenic targets of paraproteins is due to inactivation of PP2A."
      Preuss K.D. , Pfreundschuh M. , Fadle N. , Regitz E. , Raudies S. , Murwaski N. , Ahlgrimm M. , Bittenbring J. , Klotz M. , Schafer K.H. , Held G. , Neumann F. , Grass S.
      Blood118:3340-3346(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-17
    21. 21.
      "Stomatin-like protein 2 binds cardiolipin and regulates mitochondrial biogenesis and function."
      Christie D.A. , Lemke C.D. , Elias I.M. , Chau L.A. , Kirchhof M.G. , Li B. , Ball E.H. , Dunn S.D. , Hatch G.M. , Madrenas J.
      Mol. Cell. Biol.31:3845-3856(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN MITOCHONDRIAL BIOGENESIS;SUBCELLULAR LOCATION;INTERACTION WITH PHB AND PHB2;CARDIOLIPIN-BINDING;INDUCTION
    22. 22.
      "Mitochondrial and plasma membrane pools of stomatin-like protein 2 coalesce at the immunological synapse during T cell activation."
      Christie D.A. , Kirchhof M.G. , Vardhana S. , Dustin M.L. , Madrenas J.
      PLoS ONE7:E37144-E37144(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN T-CELL ACTIVATION;SUBCELLULAR LOCATION;HOMOOLIGOMERIZATION
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