TUT1(RBM21);

Speckle targeted PIP5K1A-regulated poly(A) polymerase(Star-PAP);

2.7.7.52;U6 snRNA-specific terminal uridylyltransferase 1(U6-TUTase);RNA-binding motif protein 21(RNA-binding protein 21);

Bovine (Bos taurus). 

Associates with the cleavage and polyadenylation specificity factor (CPSF) complex. Interacts with CPSF1 and CPSF3; the interaction is direct. Interacts with PIP5K1A; interaction.

Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase. Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in replication-dependent histone mRNA degradation.

Nucleus nucleolus Nucleus speckle

871

N/A

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PF03828

Bt.21690

Q1JPD6

Q1JPD6

bta:616339

9913.ENSBTAP00000015724